Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Christopher B. Eckman"'
Autor:
Wing C. Lee, Yuen K. Tsoi, Chad A. Dickey, Michael W. DeLucia, Dennis W. Dickson, Christopher B. Eckman
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 2, Pp 273-280 (2006)
The twitcher mouse is a pathologically and enzymatically authentic model of globoid cell leukodystrophy (GLD, Krabbe disease) that has been widely used for the evaluation of potential therapeutic approaches. This naturally occurring mouse model conta
Externí odkaz:
https://doaj.org/article/4421a88923ef4370b643aef1ceee8e36
Autor:
Chris De Jonghe, Cynthia Zehr, Debra Yager, Cristian-Mihail Prada, Steven Younkin, Lydia Hendriks, Christine Van Broeckhoven, Christopher B. Eckman
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 4, Pp 281-286 (1998)
Mutations in theamyloid β precursor protein(APP) gene cosegregate with autosomal dominant Alzheimer disease (AD). Brain pathology of AD is characterized by amyloid deposition in senile plaques and by neurofibrillary tangles. Amyloid deposits in AD b
Externí odkaz:
https://doaj.org/article/d23b7d6b0c164179bfd273279372be99
Autor:
Martin Citron, Christopher B. Eckman, Thekla S. Diehl, Chris Corcoran, Beth L. Ostaszewski, Weiming Xia, Georges Levesque, Peter St. George Hyslop, Steven G. Younkin, Dennis J. Selkoe
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 2, Pp 107-116 (1998)
Humans harboring missense mutations in the presenilin 1 (PS1) gene undergo progressive cerebral deposition of the 42-residue amyloid β-protein (Aβ42) at an early age and develop severe Alzheimer's disease. Aβ42is selectively elevated in the condit
Externí odkaz:
https://doaj.org/article/d13b14d33e2349ccba03e130bdbc9f3b
Autor:
Eliza Barnwell, Vasudevaraju Padmaraju, Robert Baranello, Javier Pacheco-Quinto, Craig Crosson, Zsolt Ablonczy, Elizabeth Eckman, Christopher B Eckman, Viswanathan Ramakrishnan, Nigel H Greig, Miguel A Pappolla, Kumar Sambamurti
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91531 (2014)
BACE1 (β-secretase) and α-secretase cleave the Alzheimer's amyloid β protein (Aβ) precursor (APP) to C-terminal fragments of 99 aa (CTFβ) and 83 aa (CTFα), respectively, which are further cleaved by γ-secretase to eventually secrete Aβ and A
Externí odkaz:
https://doaj.org/article/3e3c856aacf8479196377dffa67b13e4
Publikováno v:
Neurobiology of Aging. 48:83-92
Impaired clearance of amyloid-β peptide (Aβ) has been postulated to significantly contribute to the amyloid accumulation typical of Alzheimer’s disease. Among the enzymes known to degrade Aβ in vivo are endothelin-converting enzyme (ECE)-1, ECE-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ccd0023b63d47e377270d756d08252
https://doi.org/10.1016/j.neurobiolaging.2016.08.011
https://doi.org/10.1016/j.neurobiolaging.2016.08.011
Autor:
Christopher B Eckman, Ian J. Griffin
Publikováno v:
The Journal of Nutrition. 149:2079-2080
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf5de40f5d92c5bb353e022a15e2c6e
https://doi.org/10.1093/jn/nxz208
https://doi.org/10.1093/jn/nxz208
Autor:
Elizabeth A. Eckman, Austin Meszaros, Rocío Pérez-González, Christopher B. Eckman, Javier Pacheco-Quinto, Hui Peng, Efrat Levy, Dana Clausen
Accumulating evidence suggests that the abnormal aggregation of amyloid-β (Αβ) peptide in Alzheimer's disease (AD) begins intraneuronally, within vesicles of the endosomal-lysosomal pathway where Aβ is both generated and degraded. Metalloprotease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c248f6deaeab0dd8f94242e26228894
https://europepmc.org/articles/PMC6404562/
https://europepmc.org/articles/PMC6404562/
Publikováno v:
Journal of Alzheimer's Disease. 33:S101-S110
The efficient clearance of amyloid β (Aβ) is essential to modulate levels of the peptide in the brain and to prevent it from accumulating in senile plaques, a hallmark of AD pathology. We and others have shown that failure in Aβ catabolism can pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4705d3ce12089fab7ae19a517d669a22
https://doi.org/10.3233/jad-2012-129043
https://doi.org/10.3233/jad-2012-129043
Autor:
Feng Chen, Justin H. Nguyen, Christopher B. Eckman, Ann Marie T. Baine, Tomohide Hori, Norifumi Ohashi
Publikováno v:
Hepatology. 53:1294-1305
Tight junction (TJ) proteins regulate paracellular permeability in various organs, particularly in the brain neurovascular unit (1). In brain capillaries, the endothelial cell (EC) spreads itself over the entire capillary basal lamina with the two pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6dd2f193ce5c61bfa501763478f434
https://doi.org/10.1002/hep.24161
https://doi.org/10.1002/hep.24161
Publikováno v:
Neuropharmacology. 58:921-929
Loss of basal forebrain cholinergic innervation of the hippocampus and severe neuronal loss within the hippocampal CA1 region are early hallmarks of Alzheimer’s disease, and are strongly correlated with cognitive status. Various therapeutic approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cb89877d16e6301972089fe5e7f18f
https://doi.org/10.1016/j.neuropharm.2009.12.005
https://doi.org/10.1016/j.neuropharm.2009.12.005