Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Christopher B Nelson"'
Autor:
Taghreed M. Al-Turki, David G. Maranon, Christopher B. Nelson, Aidan M. Lewis, Jared J. Luxton, Lynn E. Taylor, Noelia Altina, Fei Wu, Huixun Du, JangKeun Kim, Namita Damle, Eliah Overbey, Cem Meydan, Kirill Grigorev, Daniel A. Winer, David Furman, Christopher E. Mason, Susan M. Bailey
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Telomeres are repetitive nucleoprotein complexes at chromosomal termini essential for maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long noncoding RNA of heterogeneous lengths that contributes to end-capping
Externí odkaz:
https://doaj.org/article/2d1668e811a245698e22c7714aa5796a
Autor:
Brock James Sishc, Christopher B Nelson, Miles J McKenna, Christine L R Battaglia, Andrea eHerndon, Rupa eIdate, Howard L Liber, Susan M Bailey
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Telomeres are nucleoprotein complexes comprised of tandem arrays of repetitive DNA sequence that serve to protect chromosomal termini from inappropriate degradation, as well as to prevent these natural DNA ends from being recognized as broken DNA (do
Externí odkaz:
https://doaj.org/article/1ed6a2dd123a44a4b57400112852b302
Autor:
Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we ident
Externí odkaz:
https://doaj.org/article/a2cf012d392f4eca877ee8790143a0a5
Autor:
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain largely uncharacterised. Here, w
Externí odkaz:
https://doaj.org/article/c6f9e1aee6c04251a8ad3f7b91d37b75
Autor:
Robert Lu, Christopher B. Nelson, Samuel Rogers, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108655- (2024)
Summary: Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length. One of the defining features of ALT cells is the prevalence of extrachromosomal tel
Externí odkaz:
https://doaj.org/article/7afcb5613bf944d3bed2bcb1efe3f51e
Autor:
Dhwani Hariharan, V. S. Senthil Kumar, Elizabeth L Glaser, William H. Crown, Zachary A. Wolf, Kimberley A. Fisher, Charles T. Wood, William F. Malcolm, Christopher B. Nelson, Donald S. Shepard
Publikováno v:
Health Science Reports, Vol 6, Iss 6, Pp n/a-n/a (2023)
Abstract Background and Aims Policymakers need data about the burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) among infants. This study estimates quality of life (QoL) for otherwise healthy term US infants with R
Externí odkaz:
https://doaj.org/article/50db086d8afd48fe8359acc9ba897ada
Autor:
Danielle A. Rankin, Zaid Haddadin, Loren Lipworth, Anna L. Stahl, Jon Fryzek, Mina Suh, Donald S. Shepard, Rebekkah Varjabedian, Kailee N. Fernandez, Seifein Salib, Jessica Villarreal, Mercedes Bruce, Rendie McHenry, Andrew J. Spieker, Christopher B. Nelson, Natasha B. Halasa
Publikováno v:
Therapeutic Advances in Infectious Disease, Vol 9 (2022)
Background: The burden of respiratory syncytial virus (RSV)-associated acute respiratory illnesses among healthy infants (
Externí odkaz:
https://doaj.org/article/9abe7796fb474077ac51fd4b4e380b97
Autor:
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.
Externí odkaz:
https://doaj.org/article/ec5006d7bd3c48149838ce39d9f207f5
Autor:
Christopher B. Nelson, Taghreed M. Alturki, Jared J. Luxton, Lynn E. Taylor, David G. Maranon, Keiko Muraki, John P. Murnane, Susan M. Bailey
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Telomeres, repetitive nucleoprotein complexes that protect chromosomal termini and prevent them from activating inappropriate DNA damage responses (DDRs), shorten with cell division and thus with aging. Here, we characterized the human cellular respo
Externí odkaz:
https://doaj.org/article/3f46795b8078431aa0d3ebaac15261ae
Autor:
Jason R Gantenberg, Robertus van Aalst, Nicole Zimmerman, Brendan Limone, Sandra S Chaves, William V La Via, Christopher B Nelson, Christopher Rizzo, David A Savitz, Andrew R Zullo
Publikováno v:
The Journal of Infectious Diseases, 226(Supplement_2), S164-S174. Oxford University Press
Background Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization in the United States. Preterm infants and those with select comorbidities are at highest risk of RSV-related complications. However, morbidity due to RSV infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d87b4fdad03c044229cb75deb6ee8b1
https://doi.org/10.1093/infdis/jiac185
https://doi.org/10.1093/infdis/jiac185