Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher B Marotta"'
Autor:
Weston A Nichols, Brandon J Henderson, Christopher B Marotta, Caroline Y Yu, Chris Richards, Dennis A Dougherty, Henry A Lester, Bruce N Cohen
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158032 (2016)
A number of mutations in α4β2-containing (α4β2*) nicotinic acetylcholine (ACh) receptors (nAChRs) are linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), including one in the β2 subunit called β2V287L. Two α4β2* subtypes wi
Externí odkaz:
https://doaj.org/article/f0f4f3c60e354e3f99af307bbfe38ec4
Autor:
Nandan Haloi, Shan Huang, Aaron N. Nichols, Eve J. Fine, Christopher B. Marotta, Dennis A. Dougherty, Erik Lindahl, Rebecca J. Howard, Stephen L. Mayo, Henry A. Lester
Publikováno v:
bioRxiv
To develop more sensitive fluorescent protein sensors for nicotine, we combined computational protein design, site-saturated, site-directed, and combinatorial mutagenesis with fluorescence assays, molecular dynamics simulations, and absorbance measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e006d2d998b11ecd045bc5d0daafcc24
https://doi.org/10.1101/2023.01.16.524298
https://doi.org/10.1101/2023.01.16.524298
Autor:
Noah B. Walker, Yijin Yan, Melissa A. Tapia, Brenton R. Tucker, Leanne N. Thomas, Brianna E. George, Alyssa M. West, Christopher B. Marotta, Henry A. Lester, Dennis A. Dougherty, Katherine M. Holleran, Sara R. Jones, Ryan M. Drenan
Publikováno v:
eneuro. 10:ENEURO.0449-22.2023
Mesolimbic nicotinic acetylcholine receptor (nAChRs) activation is necessary for nicotine reinforcement behavior, but it is unknown whether selective activation of nAChRs in the dopamine (DA) reward pathway is sufficient to support nicotine reinforce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be780294f1945e57b6fa526728583aee
https://doi.org/10.1523/eneuro.0449-22.2023
https://doi.org/10.1523/eneuro.0449-22.2023
Publikováno v:
ACS Appl Mater Interfaces
Ovarian cancer survival and recurrence rate are drastically affected by the amount of tumor that can be surgically removed prior to chemotherapy. Surgeons are currently limited to visual inspection, making smaller tumors difficult to remove surgicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c0be88760935aa32629704297844fc
https://doi.org/10.1021/acsami.0c14983
https://doi.org/10.1021/acsami.0c14983
Autor:
Dennis A. Dougherty, Clinton J. Regan, David P. Walton, Oliver S. Shafaat, Christopher B. Marotta
Publikováno v:
Biophysical Journal. 110(3)
A new strategy for producing caged alcohols and amines that can be released (decaged) with visible light has been developed. A series of quinone-based structures has been produced, and the mechanism of decaging has been investigated by a number of te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f732d636dbc89712361f798ca13b53
Autor:
Dennis A. Dougherty, Bruce N. Cohen, Weston A. Nichols, Christopher I. Richards, Henry A. Lester, Caroline Y. Yu, Brandon J. Henderson, Christopher B. Marotta
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158032 (2016)
PLoS ONE
PLoS ONE
A number of mutations in α4β2-containing (α4β2*) nicotinic acetylcholine (ACh) receptors (nAChRs) are linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), including one in the β2 subunit called β2V287L. Two α4β2* subtypes wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b8199e13d3480c867fbc059e5509b7
http://europepmc.org/articles/PMC4918917?pdf=render
http://europepmc.org/articles/PMC4918917?pdf=render
Nicotinic acetylcholine receptors (nAChRs) containing the α5 subunit are of interest because genome-wide association studies and candidate gene studies have identified polymorphisms in the α5 gene that are linked to an increased risk for nicotine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49429b031370256deed241c365cd819a
https://resolver.caltech.edu/CaltechAUTHORS:20140227-142503676
https://resolver.caltech.edu/CaltechAUTHORS:20140227-142503676
Publikováno v:
Biophysical Journal. 106(2)
Neuronal Nicotinic acetylcholine receptors (nAChRs) are found throughout the brain and have vital roles in memory and learning. In addition, these ligand gated ion channel are major targets of drug research for neurological disorders. Here, the two s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65800591232f7f7d46223616648527bc
Publikováno v:
Biophysical Journal. 102:117a
Neuronal nicotinic acetylcholine receptors (nAChRs) are abundantly expressed in the central nervous system. Neurons in several brain regions co-express alpha5, alpha4 and beta2 subunits. Changes in the receptor composition and stoichiometry of alpha4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdc2d89901daa43917c4b8e9dd0a178
https://doi.org/10.1016/j.bpj.2011.11.656
https://doi.org/10.1016/j.bpj.2011.11.656
Publikováno v:
Chemistry & Biology. (8):1063-1073
SummaryNicotinic acetylcholine receptors (nAChRs) are vital to neuronal signaling, are implicated in important processes such as learning and memory, and are therapeutic targets for neural diseases. The α7 nAChR has been implicated in Alzheimer's di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11fd727a068716f4ebfef16845e1f66