Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Christopher B Fox"'
Autor:
James E Futse, Songliedong Zumor-Baligi, Charles N K Ashiagbor, Susan M Noh, Christopher B Fox, Guy H Palmer
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0306092 (2024)
Efficient cattle production and provision of animal-sourced foods in much of Africa is constrained by vector-borne bacterial and protozoal diseases. Effective vaccines are not currently available for most of these infections resulting in a continuous
Externí odkaz:
https://doaj.org/article/d3cf300a23a9470e98ee842e15618bb8
Autor:
Tazio Vanni, Beatriz C Thomé, Erin Sparrow, Martin Friede, Christopher B Fox, Anna Marie Beckmann, Chuong Huynh, Gabriella Mondini, Daniela H Silveira, Juliana Y K Viscondi, Patrícia Emilia Braga, Anderson da Silva, Maria da Graça Salomão, Roberta O Piorelli, Joane P Santos, Vera Lúcia Gattás, Maria Beatriz B Lucchesi, Mayra M M de Oliveira, Marcelo E Koike, Esper G Kallas, Lucia M A Campos, Eduardo B Coelho, Marilda A M Siqueira, Cristiana C Garcia, Milene Dias Miranda, Terezinha M Paiva, Maria do Carmo S T Timenetsky, Eduardo A Adami, Milena A Akamatsu, Paulo Lee Ho, Alexander R Precioso
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0274943 (2022)
The emergence of potentially pandemic viruses has resulted in preparedness efforts to develop candidate vaccines and adjuvant formulations. We evaluated the dose-sparing effect and safety of two distinct squalene-based oil-in-water adjuvant emulsion
Externí odkaz:
https://doaj.org/article/373546a125de46d2ba8983b574567c3d
Autor:
Stella J Berendam, Papa K Morgan-Asiedu, Riley J Mangan, Shuk Hang Li, Holly Heimsath, Kan Luo, Alan D Curtis, Joshua A Eudailey, Christopher B Fox, Mark A Tomai, Bonnie Phillips, Hannah L Itell, Erika Kunz, Michael Hudgens, Kenneth Cronin, Kevin Wiehe, S Munir Alam, Koen K A Van Rompay, Kristina De Paris, Sallie R Permar, M Anthony Moody, Genevieve G Fouda
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0256885 (2021)
Different HIV vaccine regimens elicit distinct plasma antibody responses in both human and nonhuman primate models. Previous studies in human and non-human primate infants showed that adjuvants influenced the quality of plasma antibody responses indu
Externí odkaz:
https://doaj.org/article/2a76a395a34f43c0892bf0ff5ba032a9
Autor:
Susan L Baldwin, Valerie A Reese, Sasha E Larsen, Elyse Beebe, Jeff Guderian, Mark T Orr, Christopher B Fox, Steven G Reed, Rhea N Coler
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247990 (2021)
An estimated 10 million people developed tuberculosis (TB) disease in 2019 which underscores the need for a vaccine that prevents disease and reduces transmission. The aim of our current studies is to characterize and test a prophylactic tuberculosis
Externí odkaz:
https://doaj.org/article/4abe49b3716d4a6ab6d2596e49eff941
Autor:
Milena Apetito Akamatsu, Vitor Anselmo Sakihara, Bianca Pereira Carvalho, Aline de Paiva Abrantes, Maria A Sakauchi Takano, Eduardo Alfredo Adami, Fernando Seiji Yonehara, Patrícia Dos Santos Carneiro, Stefanni Rico, Alessandra Schanoski, Maurício Meros, Adrian Simpson, Tony Phan, Christopher B Fox, Paulo Lee Ho
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233632 (2020)
Increasing pandemic influenza vaccine manufacturing capacity is considered strategic by WHO. Adjuvant use is key in this strategy in order to spare the vaccine doses and by increasing immune protection. We describe here the production and stability s
Externí odkaz:
https://doaj.org/article/aa09ccaba4e44f8ca9e634c55b6f3122
Autor:
Mark T Orr, Elyse A Beebe, Thomas E Hudson, James J Moon, Christopher B Fox, Steven G Reed, Rhea N Coler
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83884 (2014)
With over eight million cases of tuberculosis each year there is a pressing need for the development of new vaccines against Mycobacterium tuberculosis. Subunit vaccines consisting of recombinant proteins are an attractive vaccine approach due to the
Externí odkaz:
https://doaj.org/article/646fa2615f7345fcb4168e0e3d5e2834
Autor:
Amy R Noe, Diego Espinosa, Xiangming Li, Jordana G A Coelho-Dos-Reis, Ryota Funakoshi, Steve Giardina, Hongfan Jin, Diane M Retallack, Ryan Haverstock, Jeffrey R Allen, Thomas S Vedvick, Christopher B Fox, Steven G Reed, Ramses Ayala, Brian Roberts, Scott B Winram, John Sacci, Moriya Tsuji, Fidel Zavala, Gabriel M Gutierrez
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107764 (2014)
The circumsporozoite protein (CSP) of Plasmodium falciparum is a major surface protein, which forms a dense coat on the sporozoite's surface. Preclinical research on CSP and clinical evaluation of a CSP fragment-based RTS, S/AS01 vaccine have demonst
Externí odkaz:
https://doaj.org/article/3b2cec5996cd4a34b37c5b812f74c3d6
Autor:
Rhea N Coler, Sylvie Bertholet, Magdalini Moutaftsi, Jeff A Guderian, Hillarie Plessner Windish, Susan L Baldwin, Elsa M Laughlin, Malcolm S Duthie, Christopher B Fox, Darrick Carter, Martin Friede, Thomas S Vedvick, Steven G Reed
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16333 (2011)
Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of gram-negative bacterial cell walls, are driven by Toll-like receptor (TLR) 4 and adaptor proteins including MyD88 and TRIF, leading to the production of in
Externí odkaz:
https://doaj.org/article/beb6c4c5d8824c4a9eada22324c31245
Autor:
Waranyoo Phoolcharoen, Balamurugan Shanmugaraj, Narach Khorattanakulchai, Piyanate Sunyakumthorn, Sathit Pichyangkul, Pornnarin Taepavarapruk, Wanlapa Praserthsee, Suchinda Malaivijitnond, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Kanjana Srisutthisamphan, Anan Jongkaewwattana, Mark Tomai, Christopher B. Fox, Suthira Taychakhoonavudh
Publikováno v:
Vaccine. 41:2781-2792
Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines
Autor:
John S. Tregoning, David C. Stirling, Ziyin Wang, Katie E. Flight, Jonathan C. Brown, Anna K. Blakney, Paul F. McKay, Robert F. Cunliffe, Valarmathy Murugaiah, Christopher B. Fox, Mitchell Beattie, Ying K. Tam, Cecilia Johansson, Robin J. Shattock
Publikováno v:
Molecular Therapy - Nucleic Acids. 31:29-42
To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccin