Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Christopher Autry"'
Autor:
Christopher Autry, Marcin P. Iwanicki, W. Gregory Roberts, Jill K. Slack-Davis, John Charles Kath, J. Thomas Parsons, Karen H. Martin, Ethan Ung, Michael Joseph Luzzio, Robert W. Tilghman, Beth Cooper
Publikováno v:
Journal of Biological Chemistry. 282:14845-14852
Focal adhesion kinase (FAK) is a member of a family of non-receptor protein-tyrosine kinases that regulates integrin and growth factor signaling pathways involved in cell migration, proliferation, and survival. FAK expression is increased in many can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5026f6d4cbbff0fe2537185bbf109aa
https://doi.org/10.1074/jbc.m606695200
https://doi.org/10.1074/jbc.m606695200
Autor:
Vincent Bernardo, Blaise Lippa, Shaughnessy Robinson, David Briere, Gary J. Martinelli, Christopher Autry, Deborah A. Gordon, Matthew A. Marx, Liuqing Wei, Joel Morris, John Jakubczak, Martin James Wythes, Elsa G. Barbacci-Tobin, Tracey Clark, Kevin Daniel Freeman-Cook, Kendra Louise Nelson, Gary Borzillo, Mahmoud N. Mansour, Francis Rajamohan, Elizabeth Knauth, Michael Joseph Luzzio, Jayvardhan Pandit, Shefali Kakar, Matthew Corbett, Chakrapani Subramanyam
Publikováno v:
Journal of medicinal chemistry. 53(12)
This paper describes the design and synthesis of novel, ATP-competitive Akt inhibitors from an elaborated 3-aminopyrrolidine scaffold. Key findings include the discovery of an initial lead that was modestly selective and medicinal chemistry optimizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592b13a322f4ed049318993bb0d78cce
https://pubmed.ncbi.nlm.nih.gov/20481595
https://pubmed.ncbi.nlm.nih.gov/20481595
Autor:
Matthew F. Dunn, John Charles Kath, Anil Mistry, F. Christopher Bi, Daniel Tyler Richter, Sabrina X. Zhao, Leonard Buckbinder, Jacquelyn Klug-McLeod, Daniel W. Kung, Gary Erik Aspnes, Michael P. Zawistoski, Robert M. Oliver, Seungil Han, Peter C. Bonnette, Ethan Ung, Molly A. McGlynn, Angel Guzman-Perez, Catherine Angela Hulford, Matthew C. Griffor, John R. Soglia, Jonathan N. Bauman, Michael Joseph Luzzio, Daniel P. Walker, Christopher Autry, Amit S. Kalgutkar, W. Gregory Roberts, Jian-Cheng Li, Beth Cooper
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
The synthesis and SAR for a series of diaminopyrimidines as PYK2 inhibitors are described. Using a combination of library and traditional medicinal chemistry techniques, a FAK-selective chemical series was transformed into compounds possessing good P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d4e40768ab5124987956906e550066
https://pubmed.ncbi.nlm.nih.gov/18951788
https://pubmed.ncbi.nlm.nih.gov/18951788
Autor:
Erika S. Roberts, Matt Griffor, Martin A. Berliner, John Charles Kath, Luis Martinez-Alsina, Huiping Xu, Catherine Angela Hulford, Matthew David Wessel, Jing Lin, Lili Yao, Marianne J. Lorenzen, Jitesh P. Jani, Christopher Autry, Pamela Whalen, Vajdos Felix, Nandini Chaturbhai Patel, Daniel Tyler Richter, Ethan Ung, Erling Emerson, Susan Deborah Lagreca, Kevin G. Coleman, Walter Gregory Roberts, Eric S. Marr, Beth C. Vetelino
Publikováno v:
Molecular Cancer Therapeutics. 8:A86-A86
Focal adhesion kinase (FAK) is a non-tyrosine kinase that localizes to focal adhesion plaques. It is activated in response to intergin binding to cellular ligands and when phosphorylated inhibits anoikis allowing for anchorage independent cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a89b708e6d295f216ac909d5d686e544
https://doi.org/10.1158/1535-7163.targ-09-a86
https://doi.org/10.1158/1535-7163.targ-09-a86