Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Christopher Auger"'
Autor:
Carly M. Knuth, Dalia Barayan, Ju Hee Lee, Christopher Auger, Lauar de Brito Monteiro, Zachary Ricciuti, Dea Metko, Lisa Wells, Hoon-Ki Sung, Robert A. Screaton, Marc G. Jeschke
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113584- (2024)
Summary: Severe burns induce a chronic hypermetabolic state that persists well past wound closure, indicating that additional internal mechanisms must be involved. Adipose tissue is suggested to be a central regulator in perpetuating hypermetabolism,
Externí odkaz:
https://doaj.org/article/28447df79fd644b48867df243ef615fa
Autor:
Reinhard Dolp, Gertraud Eylert, Christopher Auger, Ayesha Aijaz, Yufei Andy Chen, Saeid Amini-Nik, Alexandra Parousis, Andrea-Kaye Datu, Marc G. Jeschke
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Introduction Burned human skin, which is routinely excised and discarded, contains viable mesenchymal stromal/stem cells (burn-derived mesenchymal stromal/stem cells; BD-MSCs). These cells show promising potential to enable and aid wound reg
Externí odkaz:
https://doaj.org/article/4c99672dc96243a7ad62389cd1ffdb6a
Autor:
Gertraud Eylert, Reinhard Dolp, Alexandra Parousis, Richard Cheng, Christopher Auger, Magdalena Holter, Ingrid Lang-Olip, Viola Reiner, Lars-Peter Kamolz, Marc G. Jeschke
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2021)
Abstract Background Multipotent mesenchymal stromal/stem cell (MSC) therapy is under investigation in promising (pre-)clinical trials for wound healing, which is crucial for survival; however, the optimal cell dosage remains unknown. The aim was to i
Externí odkaz:
https://doaj.org/article/11b74c861cfb49bbb28d2f506981b1e3
Autor:
Christopher Auger, Carly M. Knuth, Abdikarim Abdullahi, Osai Samadi, Alexandra Parousis, Marc G. Jeschke
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 12-23 (2019)
Objective: Browning, the conversion of white adipose tissue (WAT) to a beige phenotype, has gained interest as a strategy to induce weight loss and improve insulin resistance in metabolic disorders. However, for hypermetabolic conditions stemming fro
Externí odkaz:
https://doaj.org/article/895ff41249ce44a5af0335fc4220500a
Autor:
Abdikarim Abdullahi, Carly M. Knuth, Christopher Auger, Thibacg Sivayoganathan, Alexandra Parousis, Marc G. Jeschke
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
BACKGROUND The incidence of burn injuries in older patients is dramatically increasing as the population of older people grows. Despite the increased demand for elderly burn care, the mechanisms that mediate increased morbidity and mortality in older
Externí odkaz:
https://doaj.org/article/a01eb3d9c691406385647f9429e3c99b
Autor:
Supreet Kaur, Christopher Auger, Dalia Barayan, Priyal Shah, Anna Matveev, Carly M. Knuth, Thurl E. Harris, Marc G. Jeschke
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Abstract Hypermetabolism following severe burn injuries is associated with adipocyte dysfunction, elevated beige adipocyte formation, and increased energy expenditure. The resulting catabolism of adipose leads to detrimental sequelae such as fatty li
Externí odkaz:
https://doaj.org/article/49d63209710d49869a903e83f5759917
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
For decades, adipose tissue had been considered as merely a storage depot and cushion to protect organs against trauma and injury. However, in recent years, a number of impactful studies have pinpointed the adipose tissue as an endocrine organ mediat
Externí odkaz:
https://doaj.org/article/a776373413b74000a5b35b3845317170
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
One of the most significant adverse postburn responses is abnormal scar formation, such as keloids. Despite its prolificacy, the underlying pathophysiology of keloid development is unknown. We recently demonstrated that NLRP3 inflammasome, the master
Externí odkaz:
https://doaj.org/article/61f0308f89c04d1b856a232268dbce46
Autor:
Gertraud Eylert, Reinhard Dolp, Alexandra Parousis, Richard Cheng, Christopher Auger, Magdalena Holter, Ingrid Lang-Olip, Viola Reiner, Lars-Peter Kamolz, Marc G. Jeschke
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/faa8d5fabb094cddbea5317da8a5f10d
Publikováno v:
EuPA Open Proteomics, Vol 7, Iss C, Pp 64-72 (2015)
Metabolism is the consortium of reactions within a cell which directs a variety of processes including energy synthesis, signalling and the behaviour of a biological system. Metabolic networks, and more specifically the activity of enzymes within the
Externí odkaz:
https://doaj.org/article/13def906cda74c668c1ad57be29b758d