Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Christopher A. Werley"'
Autor:
Gabriel B. Borja, Hongkang Zhang, Benjamin N. Harwood, Jane Jacques, Jennifer Grooms, Romina O. Chantre, Dawei Zhang, Adam Barnett, Christopher A. Werley, Yang Lu, Steven F. Nagle, Owen B. McManus, Graham T. Dempsey
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. Despite the potential utility an
Externí odkaz:
https://doaj.org/article/fbccbcbdfa4349c68b6c7eb8e5f3089d
Autor:
Christopher A. Werley, Stefano Boccardo, Alessandra Rigamonti, Emil M. Hansson, Adam E. Cohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Existing fluorescent protein-based sensor measurements are limited to 4 or fewer simultaneously recorded modalities due to spectral overlap. Here the authors introduce Multiplexed Optical Sensors in Arrayed Islands of Cells (MOSAIC), which enables pa
Externí odkaz:
https://doaj.org/article/da5fa069ae7f4bf7a1f2a81128754790
Publikováno v:
Physical Review X, Vol 6, Iss 3, p 031001 (2016)
Complex electrical dynamics in excitable tissues occur throughout biology, but the roles of individual ion channels can be difficult to determine due to the complex nonlinear interactions in native tissue. Here, we ask whether we can engineer a tissu
Externí odkaz:
https://doaj.org/article/68a57f0e20a24f7f95fea12a60209b7b
Autor:
He Tian, Hunter C. Davis, J. David Wong-Campos, Pojeong Park, Linlin Z. Fan, Benjamin Gmeiner, Shahinoor Begum, Christopher A. Werley, Gabriel B. Borja, Hansini Upadhyay, Himali Shah, Jane Jacques, Yitong Qi, Vicente Parot, Karl Deisseroth, Adam E. Cohen
Publikováno v:
Nature Methods.
Autor:
Pin W. Liu, Hongkang Zhang, Christopher A. Werley, Monika Pichler, Steve Ryan, Caitlin Lewarch, Jane Jacques, Jennifer Grooms, John Ferrante, Guangde Li, Dawei Zhang, Nate Bremmer, Adam Barnett, Romina Chantre, Amy E. Elder, Adam E. Cohen, Luis A. Williams, Graham T. Dempsey, Owen B. McManus
Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics. Here, we present anin vitromodel of O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088799b6f5f999c7b434c1b6a4461ccb
https://doi.org/10.1101/2022.12.12.520139
https://doi.org/10.1101/2022.12.12.520139
Autor:
He Tian, Hunter C. Davis, J. David Wong-Campos, Pojeong Park, Linlin Z. Fan, Benjamin Gmeiner, Shahinoor Begum, Christopher A. Werley, Gabriel B. Borja, Hansini Upadhyay, Himali Shah, Jane Jacques, Yitong Qi, Vicente Parot, Karl Deisseroth, Adam E. Cohen
Publikováno v:
Nature Methods. 20:469-469
Autor:
Owen B. McManus, Vivian Hecht, Violeta Yu, Chris M Hempel, Graham T. Dempsey, Ryan J. Babcock, Michael Jarosh, Joseph G. McGivern, Hongkang Zhang, Kevin Dong, Bryan D. Moyer, Christopher A. Werley
Publikováno v:
SLAS Discovery. 25:434-446
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors requires a reliable, scalable,
Autor:
Christopher A. Werley, Pojeong Park, Shahinoor Begum, He Tian, Vicente Parot, Benjamin Gmeiner, Gabriel B. Borja, Hansini Upadhyay, J. David Wong-Campos, Linlin Z. Fan, Yitong Qi, Hunter C. Davis, Himali Shah, Jane Jacques, Karl Deisseroth, Adam E. Cohen
All-optical electrophysiology can be a powerful tool for studying neural dynamics in vivo, as it offers the ability to image and perturb membrane voltage in multiple cells simultaneously. The “Optopatch” constructs combine a red-shifted archaerho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c03b9f65e85f7898879de5f0d01fbe66
https://doi.org/10.1101/2021.11.22.469481
https://doi.org/10.1101/2021.11.22.469481
Autor:
Gabriel B, Borja, Himali, Shroff, Hansini, Upadhyay, Pin W, Liu, Valeriya, Baru, Yung-Chih, Cheng, Owen B, McManus, Luis A, Williams, Graham T, Dempsey, Christopher A, Werley
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2191
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable both pre
Autor:
Graham T. Dempsey, Pin W. Liu, Hansini Upadhyay, Gabriel B. Borja, Christopher A. Werley, Valeriya Baru, Himali Shroff, Luis A. Williams, Yung-Chih Cheng, Owen B. McManus
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608296
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable both pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb35627916d5e37a95faa9e16f9544b
https://doi.org/10.1007/978-1-0716-0830-2_8
https://doi.org/10.1007/978-1-0716-0830-2_8