Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Christopher A. Waudby"'
Autor:
Dilek Guneri, Effrosyni Alexandrou, Kamel El Omari, Zuzana Dvořáková, Rupesh V. Chikhale, Daniel T. S. Pike, Christopher A. Waudby, Christopher J. Morris, Shozeb Haider, Gary N. Parkinson, Zoë A. E. Waller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The insulin-linked polymorphic region is a variable number of tandem repeats region of DNA in the promoter of the insulin gene that regulates transcription of insulin. This region is known to form the alternative DNA structures, i-motifs and
Externí odkaz:
https://doaj.org/article/f3133e77e6154bdd947d113634a42cc4
Autor:
Anna C. Papageorgiou, Michaela Pospisilova, Jakub Cibulka, Raghib Ashraf, Christopher A. Waudby, Pavel Kadeřávek, Volha Maroz, Karel Kubicek, Zbynek Prokop, Lumir Krejci, Konstantinos Tripsianes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Biomolecular polyelectrolyte complexes can be formed between oppositely charged intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly charged IDRs are abundant in the nucleus, yet few have been functio
Externí odkaz:
https://doaj.org/article/1fa7527070bb42e5a31e97f0127ee73d
Autor:
Christopher A. Waudby, Ignacio Alfonso
Publikováno v:
Journal of Magnetic Resonance Open, Vol 16, Iss , Pp 100102- (2023)
Molecules are dynamic entities, and understanding intra- and inter-molecular reactions and changes in conformation is one of the most fascinating, important and complex subjects in NMR. Conformational changes and chemical reactions result in observed
Externí odkaz:
https://doaj.org/article/e3ca1bb0e01e4cc3884ae4cbdc9c2412
Autor:
Christopher A. Waudby, Saul Alvarez-Teijeiro, E. Josue Ruiz, Simon Suppinger, Nikos Pinotsis, Paul R. Brown, Axel Behrens, John Christodoulou, Anastasia Mylona
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Phosphorylation at multiple sites is a major regulatory mechanism in cellular signalling. Here, the authors show that multisite phosphorylation of the c-JUN transcription factor by the JNK kinase exhibits intrinsic kinetics that allow a precise and t
Externí odkaz:
https://doaj.org/article/449495f650ce4cc3a30aa7a2b8fcd3ce
Autor:
Minkoo Ahn, Tomasz Włodarski, Alkistis Mitropoulou, Sammy H. S. Chan, Haneesh Sidhu, Elena Plessa, Thomas A. Becker, Nediljko Budisa, Christopher A. Waudby, Roland Beckmann, Anaïs M. E. Cassaignau, Lisa D. Cabrita, John Christodoulou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The narrow exit tunnel of the ribosome is important for cotranslational protein folding. Here, authors show that their rationally designed and engineered exit tunnel protein loops modulate the free energy of nascent chain dynamics and folding.
Externí odkaz:
https://doaj.org/article/cea56fc2e4f24b7ba30039a8d7fd533e
Autor:
Robert Creutznacher, Thorben Maass, Jasmin Dülfer, Clara Feldmann, Veronika Hartmann, Miranda Sophie Lane, Jan Knickmann, Leon Torben Westermann, Lars Thiede, Thomas J. Smith, Charlotte Uetrecht, Alvaro Mallagaray, Christopher A. Waudby, Stefan Taube, Thomas Peters
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
NMR and native mass spectrometry reveal that the major capsid VP1 protein from murine and human norovirus exhibit distinct behaviors and are differentially regulated by the binding of glycochenodeoxycholic acid.
Externí odkaz:
https://doaj.org/article/adb636c6799b4765b713f33a554a785b
Autor:
Elena Plessa, Lien P. Chu, Sammy H. S. Chan, Oliver L. Thomas, Anaïs M. E. Cassaignau, Christopher A. Waudby, John Christodoulou, Lisa D. Cabrita
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate. They show too that
Externí odkaz:
https://doaj.org/article/30b1313e15054f30a9de5b5032f07b04
Autor:
Tinna Pálmadóttir, Christopher A. Waudby, Katja Bernfur, John Christodoulou, Sara Linse, Anders Malmendal
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5191 (2023)
Amyloid fibrils may adopt different morphologies depending on the solution conditions and the protein sequence. Here, we show that two chemically identical but morphologically distinct α-synuclein fibrils can form under identical conditions. This wa
Externí odkaz:
https://doaj.org/article/46e73693990b46e1a3a94c4afed3f98c
Autor:
Alistair M. Jagger, Christopher A. Waudby, James A. Irving, John Christodoulou, David A. Lomas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
α1-Antitrypsin (AAT) is a 52 kDa serum glycoprotein, the misfolding and polymerisation of which is associated with COPD and liver disease. Here the authors demonstrate the use of high-resolution multidimensional solution-state NMR spectroscopy to ch
Externí odkaz:
https://doaj.org/article/952ff70a4c194a3cb72bb437aed03968
Autor:
Minkoo Ahn, Tomasz Włodarski, Alkistis Mitropoulou, Sammy H. S. Chan, Haneesh Sidhu, Elena Plessa, Thomas A. Becker, Nediljko Budisa, Christopher A. Waudby, Roland Beckmann, Anaïs M. E. Cassaignau, Lisa D. Cabrita, John Christodoulou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/92f54f5ec89546f796f3ac1be4fca799