Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christopher A. W. David"'
Autor:
Christopher A. W. David, Jolanda P. Vermeulen, Sabrina Gioria, Rob J. Vandebriel, Neill J. Liptrott
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5491 (2024)
Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate primary cell responses, particularly those
Externí odkaz:
https://doaj.org/article/91d1378a3d6f4b019e6d0adab9491683
Autor:
Paul Curley, James J. Hobson, Neill J. Liptrott, Edward Makarov, Amer Al-khouja, Lee Tatham, Christopher A. W. David, Helen Box, Megan Neary, Joanne Sharp, Henry Pertinez, David Meyers, Charles Flexner, Caren L. Freel Meyers, Larisa Poluektova, Steve Rannard, Andrew Owen
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1835 (2023)
Long-acting injectable (LAI) formulations promise to deliver patient benefits by overcoming issues associated with non-adherence. A preclinical assessment of semi-solid prodrug nanoparticle (SSPN) LAI formulations of emtricitabine (FTC) is reported h
Externí odkaz:
https://doaj.org/article/30c9897dc2e441029b763227a146a61d
Autor:
Christopher A. W. David, M. Estela del Castillo Busto, Susana Cuello-Nuñez, Heidi Goenaga-Infante, Michael Barrow, David G. Fernig, Patricia Murray, Matthew J. Rosseinsky, Andrew Owen, Neill J. Liptrott
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Background Safe and rational development of nanomaterials for clinical translation requires the assessment of potential biocompatibility. Autophagy, a critical homeostatic pathway intrinsically linked to cellular health and inflammation, has
Externí odkaz:
https://doaj.org/article/d61717e8f0e94888a27f085b19fa15aa
Autor:
Alexander J. Plant-Hately, Burcu Eryilmaz, Christopher A. W. David, Danielle E. Brain, Bethany J. Heaton, Yvonne Perrie, Neill J. Liptrott
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2470 (2022)
Lipidic nanoparticles (LNP), particularly liposomes, have been proven to be a successful and versatile platform for intracellular drug delivery for decades. Whilst primarily developed for small molecule delivery, liposomes have recently undergone a r
Externí odkaz:
https://doaj.org/article/f085aa3173a5414e81b0a43696c6b45f
Autor:
Christopher A. W. David, Michael Barrow, Patricia Murray, Matthew J. Rosseinsky, Andrew Owen, Neill J. Liptrott
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5610 (2020)
Investigation of the potential for nanomaterials to generate immunogenic effects is a key aspect of a robust preclinical evaluation. In combination with physicochemical characterization, such assessments also provide context for how material attribut
Externí odkaz:
https://doaj.org/article/2749e90b95724055934e1f92b6c471dd
Autor:
Owen, Paul Curley, James J. Hobson, Neill J. Liptrott, Edward Makarov, Amer Al-khouja, Lee Tatham, Christopher A. W. David, Helen Box, Megan Neary, Joanne Sharp, Henry Pertinez, David Meyers, Charles Flexner, Caren L. Freel Meyers, Larisa Poluektova, Steve Rannard, Andrew
Publikováno v:
Pharmaceutics; Volume 15; Issue 7; Pages: 1835
Long-acting injectable (LAI) formulations promise to deliver patient benefits by overcoming issues associated with non-adherence. A preclinical assessment of semi-solid prodrug nanoparticle (SSPN) LAI formulations of emtricitabine (FTC) is reported h
Publikováno v:
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
Nanoparticles including nanomedicines are known to be recognised by and interact with the immune system. As these interactions may result in adverse effects, for safety evaluation, the presence of such interactions needs to be investigated. Nanomedic