Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christopher A. Strulson"'
Autor:
Xuanwen Li, Nicholas A. Pierson, Xiaoqing Hua, Bhumit A. Patel, Michael H. Olma, Christopher A. Strulson, Simon Letarte, Douglas D. Richardson
Publikováno v:
Journal of Pharmaceutical Sciences. 112:691-699
The use of multi-attribute method (MAM) for identity and purity testing of biopharmaceuticals offers the ability to complement and replace multiple conventional analytical technologies with a single mass spectrometry (MS) method. Phase-appropriate me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeeeee50a41e438f26f936b62c5de9b0
https://doi.org/10.1016/j.xphs.2022.10.018
https://doi.org/10.1016/j.xphs.2022.10.018
Autor:
Chengdong Xu, Sumee Khanal, Nicholas A. Pierson, Jorge Quiroz, Brent Kochert, Xiaoyu Yang, David Wylie, Christopher A. Strulson
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:8317-8330
Monoclonal antibody (mAb) coformulation containing two therapeutic proteins provides benefits of improved therapeutic efficacy and better patient compliance. Monitoring of the individual mAb stability in the coformulation is critical to ensure its qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67f2fa84908280eb9a81f203a9436a8
https://doi.org/10.1007/s00216-022-04366-z
https://doi.org/10.1007/s00216-022-04366-z
Autor:
Anna Fryszkowska, Chihui An, Oscar Alvizo, Goutami Banerjee, Keith A. Canada, Yang Cao, Duane DeMong, Paul N. Devine, Da Duan, David M. Elgart, Iman Farasat, Donald R. Gauthier, Erin N. Guidry, Xiujuan Jia, Jongrock Kong, Nikki Kruse, Katrina W. Lexa, Alexey A. Makarov, Benjamin F. Mann, Erika M. Milczek, Vesna Mitchell, Jovana Nazor, Claudia Neri, Robert K. Orr, Peter Orth, Eric M. Phillips, James N. Riggins, Wes A. Schafer, Steven M. Silverman, Christopher A. Strulson, Nandhitha Subramanian, Rama Voladri, Hao Yang, Jie Yang, Xiang Yi, Xiyun Zhang, Wendy Zhong
Publikováno v:
Science (New York, N.Y.). 376(6599)
The emergence of new therapeutic modalities requires complementary tools for their efficient syntheses. Availability of methodologies for site-selective modification of biomolecules remains a long-standing challenge, given the inherent complexity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e1c890246ba90b63af46174410e3e6
https://pubmed.ncbi.nlm.nih.gov/35709283
https://pubmed.ncbi.nlm.nih.gov/35709283
Autor:
Xuanwen Li, Nicholas A. Pierson, Xiaoqing Hua, Bhumit A. Patel, Michael H. Olma, Christopher A. Strulson, Simon Letarte, Douglas D. Richardson
The use of Multi-attribute method (MAM) for identity and purity testing of biopharmaceuticals offers the ability to complement and replace multiple conventional analytical technologies with a single mass spectrometry (MS) method. Method qualification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41b8c5b8cc24a26e2e9271085bbd3f93
https://doi.org/10.1101/2022.05.01.490194
https://doi.org/10.1101/2022.05.01.490194
Autor:
Xiaoqing Hua, Benjamin F. Mann, Raffeal Bennett, Devin M. Makey, Erik L. Regalado, Christopher A. Strulson, Tian Lu, John W. Loughney, Alexey A. Makarov, Vladimir Shchurik, Hayley R Lhotka, Ray T. McClain, Imad A. Haidar Ahmad, Ian Mangion
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1173
Recent advances in biomedical and pharmaceutical processes has enabled a notable increase of protein- and peptide-based drug therapies and vaccines that often contain a higher-order structure critical to their efficacy. Hyphenation of chromatographic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d629261fccdeecf652241e2630b4aae3
https://pubmed.ncbi.nlm.nih.gov/33845343
https://pubmed.ncbi.nlm.nih.gov/33845343
Autor:
Christopher A. Strulson, Xuanwen Li, Rong-Sheng Yang, Divya Chandra, Douglas D. Richardson, An Chi, Jonathan Welch, Smaranda Bodea, Alex Dow, Simon Letarte, Gregory C. Adam
Polysorbate is widely used to maintain stability of biotherapeutic proteins in formulation development. Degradation of polysorbate can lead to particle formation in drug products, which is a major quality concern and potential patient risk factor. En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ab5b0f5d0ae61add439523cf28edba1
https://doi.org/10.1101/2020.10.07.330076
https://doi.org/10.1101/2020.10.07.330076
Publikováno v:
Biochemistry. 56:2537-2548
General acid–base catalysis is a key mechanistic strategy in protein and RNA enzymes. Ribozymes use hydrated metal ions, nucleobases, and organic cofactors to carry this out. In most small ribozymes, a guanosine is positioned to participate in prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4399ab9fc7d7b2fff924e9e1ab9bc453
https://doi.org/10.1021/acs.biochem.7b00174
https://doi.org/10.1021/acs.biochem.7b00174
Autor:
Kevin M. Maloney, Guy R. Humphrey, Christopher A. Strulson, Hong Ren, Donald R. Gauthier, Guangtao Li, Rong Xiang
Publikováno v:
Green Chemistry. 19:4002-4006
The increasing employment of palladium-catalyzed reactions in the synthesis of active pharmaceutical ingredients (APIs) has created a pressing need for ultra-efficient palladium removal of the resulting metal contaminants. This communication discusse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b54daf5c17dffad8f24af070db7844a
https://doi.org/10.1039/c7gc01765k
https://doi.org/10.1039/c7gc01765k
Autor:
Xiaoping Zhang, Xiaohong Zhu, Terri M. Kelly, Christopher A. Strulson, Sobhana Babu Boga, Songnian Lin, Lin Yan, Shane W. Krska, Craig A. Parish, Ahmet Kekec, Nicholas A. Pierson, Eric Streckfuss, Dmitri A. Pissarnitski, Weijuan Tang
Publikováno v:
Bioconjugate chemistry. 30(4)
A synthetic method to access novel azido-insulin analogs directly from recombinant human insulin (RHI) was developed via diazo-transfer chemistry using imidazole-1-sulfonyl azide. Systematic optimization of reaction conditions led to site-selective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ff3604a4c6b1eec8b15b0b500bdf0d
https://pubmed.ncbi.nlm.nih.gov/30946565
https://pubmed.ncbi.nlm.nih.gov/30946565
Publikováno v:
Biochemistry. 56(20)
General acid-base catalysis is a key mechanistic strategy in protein and RNA enzymes. Ribozymes use hydrated metal ions, nucleobases, and organic cofactors to carry this out. In most small ribozymes, a guanosine is positioned to participate in proton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aeda7d42e9c84c75a66c98d4c44b0fd4
https://pubmed.ncbi.nlm.nih.gov/28485924
https://pubmed.ncbi.nlm.nih.gov/28485924