Zobrazeno 1 - 10
of 2 605
pro vyhledávání: '"Christopher A. Smith"'
Autor:
Christopher A. Smith, Gregory J. Sonneson, Robert J. Hoey, Jennifer M. Hinerman, Kimberly Sheehy, Richard Walter, Andrew B. Herr, James R. Horn
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTCamelid heavy-chain-only antibodies are a unique class of antibody that possesses only a single variable domain (termed VHH) for antigen recognition. Despite their apparent canonical mechanism of target recognition, where a single VHH domain
Externí odkaz:
https://doaj.org/article/dcf8946445c34a6d860dc157fbf36be2
Autor:
Jo E. Lewis, Orla RM. Woodward, Danaé Nuzzaci, Christopher A. Smith, Alice E. Adriaenssens, Lawrence Billing, Cheryl Brighton, Benjamin U. Phillips, John A. Tadross, Sarah J. Kinston, Ernesto Ciabatti, Berthold Göttgens, Marco Tripodi, David Hornigold, David Baker, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101604- (2022)
Objective: Insulin-like peptide 5 (INSL5) signalling, through its cognate receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), has been reported to be orexigenic, and the high fat diet (HFD) preference observed in wildtype mice is altered
Externí odkaz:
https://doaj.org/article/6a6921f8d6fa48b28215077b1699f22b
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105256- (2022)
Summary: Antiquated and inefficient data-sharing practices represent one of the key obstacles to advancing sustainability goals through green chemistry. To this end, we need to robustly link data on chemical impacts with new chemical design strategie
Externí odkaz:
https://doaj.org/article/3c22131ecee94c2da1627e71fefe01cf
Autor:
Deepti Chopra, Mala Joneja, Gurjit Sandhu, Christopher A. Smith, Catherine M. Spagnuolo, Lawrence Hookey
Publikováno v:
BMC Medical Education, Vol 20, Iss 1, Pp 1-7 (2020)
Abstract Background The letter of recommendation is currently an integral part of applicant selection for residency programs. Internal medicine residents will spend much time and expense completing sub-specialty away electives to obtain a letter of r
Externí odkaz:
https://doaj.org/article/26841594e95e4e23b2077a486ba5094d
Publikováno v:
BMC Health Services Research, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Hospitalized patients are designated alternate level of care (ALC) when they no longer require hospitalization but discharge is delayed while they await alternate disposition or living arrangements. We assessed hospital costs and
Externí odkaz:
https://doaj.org/article/6f85920a50384857900a2dd3032e81cd
Autor:
Emily L. Miedzybrodzka, Rachel E. Foreman, Van B. Lu, Amy L. George, Christopher A. Smith, Pierre Larraufie, Richard G. Kay, Deborah A. Goldspink, Frank Reimann, Fiona M. Gribble
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101356- (2021)
Objective: Motilin is a proximal small intestinal hormone with roles in gastrointestinal motility, gallbladder emptying, and hunger initiation. In vivo motilin release is stimulated by fats, bile, and duodenal acidification but the underlying molecul
Externí odkaz:
https://doaj.org/article/7038fb1fad7e44e6bafe941133cf6234
Autor:
Rune E. Kuhre, Ida M. Modvig, Sara L. Jepsen, Hüsün S. Kizilkaya, Cecilie Bæch-Laursen, Christopher A. Smith, Frank Reimann, Fiona M. Gribble, Mette M. Rosenkilde, Jens J. Holst
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans
Externí odkaz:
https://doaj.org/article/db177ab402a0435f8ee24eca3d9ff60d
Autor:
Peter R. Johnston, Luis Quijada, Christopher A. Smith, Hans-Otto Baral, Tsuyoshi Hosoya, Christiane Baschien, Kadri Pärtel, Wen-Ying Zhuang, Danny Haelewaters, Duckchul Park, Steffen Carl, Francesc López-Giráldez, Zheng Wang, Jeffrey P. Townsend
Publikováno v:
IMA Fungus, Vol 10, Iss 1, Pp 1-22 (2019)
Abstract Fungi in the class Leotiomycetes are ecologically diverse, including mycorrhizas, endophytes of roots and leaves, plant pathogens, aquatic and aero-aquatic hyphomycetes, mammalian pathogens, and saprobes. These fungi are commonly detected in
Externí odkaz:
https://doaj.org/article/34ab96d0dced4bc68cf7f5d7aa18514d
Autor:
Van B. Lu, Juraj Rievaj, Elisabeth A. O’Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble, Frank Reimann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodo
Externí odkaz:
https://doaj.org/article/e0d5bffcb836471e9eeb57ed1e965989
Autor:
Deborah A. Goldspink, Van B. Lu, Emily L. Miedzybrodzka, Christopher A. Smith, Rachel E. Foreman, Lawrence J. Billing, Richard G. Kay, Frank Reimann, Fiona M. Gribble
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107833- (2020)
Summary: Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine c
Externí odkaz:
https://doaj.org/article/afe639a516f74f0cacef5f0a9acfdb57