Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christopher A. Ogiela"'
Autor:
Gilbert Diaz, Lee C. Preusser, Ann Mikhail, Christopher A. Ogiela, Lynch John K, Philip R. Kym, Lisa M. Hernández, Dariusz Wodka, Gang Zhao, Doug H. Falls, Eugene N. Bush, James S. Polakowski, Andrew S. Judd, Robin Shapiro, Hing L. Sham, James J. Napier, Christine A. Collins, Kennan C. Marsh, Victoria Knourek-Segel, Glenn A. Reinhart, Thomas J Campbell, Sevan Brodjian, Michael E. Brune, Brian A. Droz, Mathew M. Mulhern, Kathryn Houseman, Regina M. Reilly, Brian D. Dayton, Ryan M. Fryer, James T. Limberis, Rajesh R. Iyengar, Freeman Jennifer C
Publikováno v:
Journal of Medicinal Chemistry. 49:6569-6584
Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a chromone-2-carboxamide series as having excellent safety against t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b667ab564d57ac2f27112dd9382a72ab
https://doi.org/10.1021/jm060683e
https://doi.org/10.1021/jm060683e
Autor:
Christopher A. Ogiela, Verlyn G. Schaefer, Regina M. Reilly, H. Douglas Falls, Sevan Brodjian, Christine A. Collins, Brian D. Dayton, Dennis G Fry, Wiweka Kaszubska
Publikováno v:
Journal of Molecular Endocrinology. 37:51-62
Ghrelin, a 28 amino acid, octanoylated peptide, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). In addition to various endocrine functions, including stimulation of GH release, ghrelin has been characterized as an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2413c63ba94a30c996214e7be9ed85b3
https://doi.org/10.1677/jme.1.01943
https://doi.org/10.1677/jme.1.01943
Autor:
Brian D. Dayton, Jared C. Lewis, Lisa E. Hernandez, Philip R. Kym, Anil Vasudevan, Andrew J. Souers, Robert G. Gentles, Sevan Brodjian, Ju Gao, Christine A. Collins, Kennan C. Marsh, Dennis G Fry, Dariusz Wodka, Christopher A. Ogiela
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4873-4877
A high-throughput screen was performed in order to identify chemotypes that are bound by the melanin concentrating hormone receptor-1 (MCHr1). A novel 2-amino-8-alkoxyquinoline compound (1) was identified and subsequently optimized using a parallel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d57bd7e14187747241196da398a79e
https://doi.org/10.1016/j.bmcl.2004.07.032
https://doi.org/10.1016/j.bmcl.2004.07.032
Autor:
Andrew J. Souers, Brian D. Dayton, Jared C. Lewis, Anil Vasudevan, Philip R. Kym, Dennis G Fry, Ju Gao, Christopher A. Ogiela, Dariusz Wodka, Sevan Brodjian, Kennan C. Marsh, Christine A. Collins, Lisa E. Hernandez
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4883-4886
Prior SAR studies on 2-amino-8-alkoxyquinoline MCHr1 antagonists demonstrated that compounds with acyclic amide-containing sidechains displayed exceptional binding and functional potency, but negligible CNS penetration. Related analogs with acyclic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025cb6cb6c9648e160dfcb4804d09c0d
https://doi.org/10.1016/j.bmcl.2004.07.035
https://doi.org/10.1016/j.bmcl.2004.07.035
Autor:
Thomas A. Fey, Brian A. Droz, Hing L. Sham, Christi Kosogof, Zhili Xin, Michael D. Serby, Kathy Sarris, H. Douglas Falls, Robin Shapiro, Hongyu Zhao, Michael E. Brune, Bo Liu, Ethan D. Hoff, Gang Liu, Charles W. Hutchins, Mei Liu, David W A Beno, Christopher A. Ogiela, Chun W. Lin, Eugene N. Bush, Bruce G. Szczepankiewicz, Peer B. Jacobson, Christine A. Collins, Victoria Knourek-Segel, Teresa M. Turner
Publikováno v:
Journal of medicinal chemistry. 49(15)
The discovery and pharmacological evaluation of potent, selective, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported. Previously, 2,4-diaminopyrimidine-based GHS-R antagonists reported from our laboratories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf86a3628feb1bafa985c9105c7d6f5
https://pubmed.ncbi.nlm.nih.gov/16854051
https://pubmed.ncbi.nlm.nih.gov/16854051
Autor:
Christopher A. Ogiela, Regina M. Reilly, Sevan Brodjian, Hanna Sidorowicz, Dennis G Fry, Brian D. Dayton, Leigh Frost, Teresa McNally, Christine A. Collins
Publikováno v:
The international journal of biochemistrycell biology. 38(8)
Melanin-concentrating hormone (MCH), an orexigenic neuropeptide in mammals, activates a G-protein coupled receptor, MCHR1. It is expected that antagonists of MCHR1 function will prove therapeutically useful as anti-obesity agents. Intracellular signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68047234b9c7c87f6d766d7e7796f6fa
https://pubmed.ncbi.nlm.nih.gov/16524757
https://pubmed.ncbi.nlm.nih.gov/16524757
Autor:
Dariusz Wodka, Anil Vasudevan, Christopher A. Ogiela, Lisa E. Hernandez, Mary K. Verzal, Sevan Brodjian, Andrew J. Souers, Philip R. Kym, Christine A. Collins, Ju Gao, Kennan C. Marsh, Dennis G Fry, Brian D. Dayton
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(19)
The continued SAR investigation of 2-amino-8-alkoxy quinolines as melanin concentrating hormone receptor-1 (MCHr1) antagonists is reported. Prior hit-to-lead efforts resulted in the identification of 1 as a robust MCHr1 antagonist. Further delineatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddc0c79f9cc7b8060de65e4bf1caaa7
https://pubmed.ncbi.nlm.nih.gov/15341943
https://pubmed.ncbi.nlm.nih.gov/15341943
Autor:
Jae Hwan-Soo, Nelson Grihalde, Christopher A. Ogiela, Chun W Lin, Christine A. Collins, Bryan K. Sorensen, Jyoti R. Patel, Andrew L. Adler, M. Winn, Ravi Kurukulasuriya, Jeffrey R Rohde, James T. Link
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(9)
Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ca9c8912c7e30ad81ac6583dc94e53
https://pubmed.ncbi.nlm.nih.gov/15080976
https://pubmed.ncbi.nlm.nih.gov/15080976
Autor:
Teresa McNally, Stevan W. Djuric, Terry Pederson, Christopher A. Ogiela, Chun W. Lin, Nelson Grihalde, Regina M. Reilly, Christine A. Collins
Publikováno v:
Peptides. 25(7)
The glucagon receptor was cloned from cynolomologous monkey. A frame-shift mutation at the 3′ end of the monkey transcript results in a C-terminal extension of 14 amino acids. This extension is not observed in either the human or rodent glucagon re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd25f81b2578326bef39dbfcbc03a45
https://pubmed.ncbi.nlm.nih.gov/15245877
https://pubmed.ncbi.nlm.nih.gov/15245877