Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christopher A. Lavender"'
Autor:
Scott A. Lujan, Matthew J. Longley, Margaret H. Humble, Christopher A. Lavender, Adam Burkholder, Emma L. Blakely, Charlotte L. Alston, Grainne S. Gorman, Doug M. Turnbull, Robert McFarland, Robert W. Taylor, Thomas A. Kunkel, William C. Copeland
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-34 (2020)
Abstract Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease. Results To decipher connections b
Externí odkaz:
https://doaj.org/article/15e2915608854379b2a6c820537c4ae2
Autor:
Andrew J. Oldfield, Telmo Henriques, Dhirendra Kumar, Adam B. Burkholder, Senthilkumar Cinghu, Damien Paulet, Brian D. Bennett, Pengyi Yang, Benjamin S. Scruggs, Christopher A. Lavender, Eric Rivals, Karen Adelman, Raja Jothi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The mechanisms underlying specific TSS selection in mammals remain unclear. Here the authors show that the ubiquitously expressed transcription factor NF-Y regulate fidelity of transcription initiation at gene promoters, maintaining the region upstre
Externí odkaz:
https://doaj.org/article/71e2bfa890304bdaa5931f07b5e2e8a9
Autor:
Adam B. Burkholder, Scott A. Lujan, Christopher A. Lavender, Sara A. Grimm, Thomas A. Kunkel, David C. Fargo
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-19 (2018)
Abstract Background Identification of mutations from next-generation sequencing data typically requires a balance between sensitivity and accuracy. This is particularly true of DNA insertions and deletions (indels), that can impart significant phenot
Externí odkaz:
https://doaj.org/article/b4ed54e91cb7433e914d1cbea74bcdfe
Autor:
Michael P Meers, Telmo Henriques, Christopher A Lavender, Daniel J McKay, Brian D Strahl, Robert J Duronio, Karen Adelman, A Gregory Matera
Publikováno v:
eLife, Vol 6 (2017)
Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in D
Externí odkaz:
https://doaj.org/article/19420f092d6b40889a2dd60b3dd98ea5
Autor:
Richard Quinton, Brooke Meader, Katie L. Lewis, Janet E. Hall, Corrine K. Welt, Joan E. Bailey-Wilson, Leslie G. Biesecker, Alessandro Albano, Christopher A. Lavender, Natalie Shaw, Angela Delaney, Verónica Mericq, Paulina M. Merino, Stephanie B. Seminara, Adam B. Burkholder, Lacey Plummer, Kathryn A. Martin
Publikováno v:
J Clin Endocrinol Metab
Context Functional hypothalamic amenorrhea (HA) is a common, acquired form of hypogonadotropic hypogonadism that occurs in the setting of energy deficits and/or stress. Variability in individual susceptibility to these stressors, HA heritability, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4abe6f45a8b6d00cda1d49468209b2d
https://doi.org/10.1210/clinem/dgaa609
https://doi.org/10.1210/clinem/dgaa609
Autor:
Raja Jothi, Telmo Henriques, Christopher A. Lavender, Dhirendra Kumar, Senthilkumar Cinghu, Karen Adelman, Andrew J. Oldfield, Brian D. Bennett, Adam B. Burkholder, Pengyi Yang, Damien Paulet, Benjamin S. Scruggs, Eric Rivals
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3072. ⟨10.1038/s41467-019-10905-7⟩
Nature Communications, 2019, 10 (1), pp.3072. ⟨10.1038/s41467-019-10905-7⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3072. ⟨10.1038/s41467-019-10905-7⟩
Nature Communications, 2019, 10 (1), pp.3072. ⟨10.1038/s41467-019-10905-7⟩
Faithful transcription initiation is critical for accurate gene expression, yet the mechanisms underlying specific transcription start site (TSS) selection in mammals remain unclear. Here, we show that the histone-fold domain protein NF-Y, a ubiquito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1bb1f2117f6d28d34f1e6ad6a5da9b
http://link.springer.com/article/10.1038/s41467-019-10905-7
http://link.springer.com/article/10.1038/s41467-019-10905-7
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 1, p e1007571 (2020)
PLoS Computational Biology, Vol 16, Iss 1, p e1007571 (2020)
High-throughput sequencing has become ubiquitous in biomedical sciences. As new technologies emerge and sequencing costs decline, the diversity and volume of available data increases exponentially, and successfully navigating the data becomes more ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0346c3508ee1c70147a1acbcd77ebb08
http://europepmc.org/articles/PMC7001987
http://europepmc.org/articles/PMC7001987
Autor:
Pierre R. Bushel, Yuanyuan Li, Leping Li, Christopher A. Lavender, Thuy-Ai T. Nguyen, Carl W. Anderson, Jianying Li, Michael A. Resnick, Sara A. Grimm, James M. Ward, David C. Fargo, Brian D. Bennett, Daniel Menendez
Publikováno v:
Nucleic Acids Research. 46:8153-8167
p53 transcriptional networks are well-characterized in many organisms. However, a global understanding of requirements for in vivo p53 interactions with DNA and relationships with transcription across human biological systems in response to various p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50254bdaee311f90a9544d609cc80de2
https://doi.org/10.1093/nar/gky720
https://doi.org/10.1093/nar/gky720
Autor:
Adam B. Burkholder, Karen Adelman, Christopher A. Lavender, Ginger W. Muse, David C. Fargo, Benjamin S. Scruggs, Telmo Henriques, Michiko O. Inouye, Lucy H. Williams
Publikováno v:
Genes & Development. 32:26-41
Regulation by gene-distal enhancers is critical for cell type-specific and condition-specific patterns of gene expression. Thus, to understand the basis of gene activity in a given cell type or tissue, we must identify the precise locations of enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a763ec27fde3d2eab7018545b0f8f3a8
https://doi.org/10.1101/gad.309351.117
https://doi.org/10.1101/gad.309351.117
Autor:
Christopher A. Lavender, David C. Fargo, Sara A. Grimm, Adam B. Burkholder, Scott A. Lujan, Thomas A. Kunkel
Publikováno v:
BMC Genomics
BMC Genomics, Vol 19, Iss 1, Pp 1-19 (2018)
BMC Genomics, Vol 19, Iss 1, Pp 1-19 (2018)
Background Identification of mutations from next-generation sequencing data typically requires a balance between sensitivity and accuracy. This is particularly true of DNA insertions and deletions (indels), that can impart significant phenotypic cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2812e44b824a33612fbe46a09f16116
http://europepmc.org/articles/PMC5944071
http://europepmc.org/articles/PMC5944071