Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christopher A. Koval"'
Publikováno v:
Journal of Pharmaceutical Sciences. 83:1418-1420
The solubility behavior of nicardipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic+ ++ acid methyl 2-[methyl(phenyl-methyl)amino]ethyl diester), a calcium channel blocker, used in the treatment of chronic stable angina and mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381078fbc716dd09ad61cf0af77a0f52
https://doi.org/10.1002/jps.2600831011
https://doi.org/10.1002/jps.2600831011
Publikováno v:
Pharmaceutical Research. :750-752
The nonopioid kappa agonist analgesic amine, DuP 747, as a hydrochloride salt exhibited an aqueous solubility of 3 mg/ml. This solubility was insufficient to provide the desired dose in a solution formulation for intramuscular administration. Aqueous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c3f4ec0a412713c1afc201a8d212578
https://doi.org/10.1023/a:1015895303804
https://doi.org/10.1023/a:1015895303804
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 12(8)
A typical anhydrous moricizine hydrochloride, an antiarrhythmic agent, is a non-hygroscopic crystalline material. Three lots of moricizine hydrochloride were found to deliquesce within a day at 85% relative humidity, exhibit different X-ray powder di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b54a4fb72a10e127a291b9ca8653e9
https://pubmed.ncbi.nlm.nih.gov/7819378
https://pubmed.ncbi.nlm.nih.gov/7819378
Publikováno v:
Journal of pharmaceutical sciences. 79(5)
Aminopeptidase inhibitors may be useful for improving the systemic bioavailability of peptide drugs administered nasally or by other routes. Preferably, their effects would be rapidly reversible. The recovery of peptide hydrolytic activity after expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a276945d6edf2fe7b3f91f6184105946
https://pubmed.ncbi.nlm.nih.gov/2352157
https://pubmed.ncbi.nlm.nih.gov/2352157
Publikováno v:
Life sciences. 47(3)
Thymopentin is a pentapeptide with immunomodulatory activity. Transmucosal delivery may offer advantages over other routes, but published data have shown relatively poor efficacy when dosed nasally. Metabolism of thymopentin by the rat nasal mucosa a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848fdd1110183e21ec27503f62d34d20
https://pubmed.ncbi.nlm.nih.gov/2201862
https://pubmed.ncbi.nlm.nih.gov/2201862
Publikováno v:
Pharmaceutical Research. :615-618
Buccal delivery of opioid analgesics and antagonists is a useful way of improving bioavailability relative to the oral route. These compounds taste bitter, however. Various prodrugs of nalbuphine, naloxone, naltrexone, oxymorphone, butorphanol, and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa3b96c82776d3c47613fb3128f568da
https://doi.org/10.1023/a:1015958417047
https://doi.org/10.1023/a:1015958417047
Publikováno v:
Journal of Pharmaceutical Sciences. 76:356-358
In an effort to improve the oral bioavailability of naltrexone [17-(cyclopropylmethyl)-4,5 alpha-epoxy-3,14-dihydroxymorphinan-6-one;1], a number of prodrug esters on the 3-hydroxyl group were prepared: the anthranilate (2), acetylsalicylate (3), ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614091d14a0f721cfa6d663c4572ac67
https://doi.org/10.1002/jps.2600760503
https://doi.org/10.1002/jps.2600760503