Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christopher A. Hurley"'
Publikováno v:
Drug Discovery Today. 27:134-150
Despite the devastating impact of many lung diseases on human health, there is still a significant unmet medical need in respiratory diseases, for which inhaled delivery represents a crucial strategy. More guidance on how to design and carry out mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd52519089dcbbbea67cae84a75d499
https://doi.org/10.1016/j.drudis.2021.09.005
https://doi.org/10.1016/j.drudis.2021.09.005
Autor:
Xingrong Liu, Nico Ghilardi, Simon Charles Goodacre, Michael Siu, Jim Nonomiya, G. Buckley, Adam R. Johnson, Yun-Xing Cheng, F.A. Romero, Nick Ray, Rohan Mendonca, C. Robinson, Yuen Po-Wai, Jane R. Kenny, Marya Liimatta, Terry Kellar, Mark Zak, Gary Salmon, J. Lloyd, D.G. Brown, Neville James Mclean, Joseph P. Lyssikatos, Emily J. Hanan, Patrick J. Lupardus, Pawan Bir Kohli, Christopher A. Hurley, Guiling Zhao, Paul Gibbons, Peter H. Crackett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1522-1531
Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e867a785065ce94ed8447c01ad10c0
https://doi.org/10.1016/j.bmcl.2019.04.008
https://doi.org/10.1016/j.bmcl.2019.04.008
Autor:
Durairaj Baskaran, Jimmy W. Mays, Christopher M. Hurley, Georgios Sakellariou, George V. Theodosopoulos
Publikováno v:
Polymer Chemistry. 7:4090-4099
A novel hydrocarbon-soluble trifunctional organolithium initiator, with no polar-additive requirements, has been synthesized for use in anionic polymerization. The complete synthesis of the unsaturated tri-diphenylethylene compound, 4,4,4-(ethane-1,1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::276cfddf1ed17464c282dbe0a0e05921
https://doi.org/10.1039/c6py00720a
https://doi.org/10.1039/c6py00720a
Publikováno v:
Surface and Interface Analysis. 48:105-110
Layer-by-layer assemblies consisting of alternating layers of nitrilotris(methylene)triphosphonic acid (NTMP), a polyfunctional corrosion inhibitor, and zirconium(IV) were prepared on alumina. In particular, a nine-layer (NTMP/Zr(IV))4NTMP stack coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::728564a2e09c1d2f57aef85b57ed91f9
https://doi.org/10.1002/sia.5914
https://doi.org/10.1002/sia.5914
Autor:
Steve Magnuson, Michael Siu, Christopher A. Hurley, Mark Ultsch, Joseph P. Lyssikatos, Wade S. Blair, Rebecca Pulk, Paul Gibbons, Charles Eigenbrot, Vickie Tsui, Bing-Yan Zhu, Deepak Sampath, Liu Wendy, Kathy Barrett, S. Cyrus Khojasteh, Leslie Lee, Nico Ghilardi, Richard Pastor, Yisong Xiao, Megan Berry, Jane R. Kenny, Jacob Z. Chen, Hoa Le, Christine Chang, Haiying He
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5014-5021
The advancement of a series of ligand efficient 2-amino-[1,2,4]triazolo[1,5-a]pyridines, initially identified from high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in a mouse xenograft model is disclosed. Download : Downlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681fd99055683a4b0d3829fed9eaeb2f
https://doi.org/10.1016/j.bmcl.2013.06.008
https://doi.org/10.1016/j.bmcl.2013.06.008
Autor:
Janusz J. Kulagowski, Claire Morris, Leslie Lee, Kathy Barrett, Sean P. Flynn, Richard Pastor, Michael Siu, Charles Eigenbrot, Deepak Sampath, Christine Chang, Jane R. Kenny, Aihe Zhou, Jeremy Murray, Joseph P. Lyssikatos, Christopher A. Hurley, Emily J. Hanan, Jeffrey M. Blaney, Wade S. Blair, Tom Rawson, Paul Gibbons, Steven Magnuson, Mark Ultsch, Anne van Abbema
Publikováno v:
Journal of Medicinal Chemistry. 55:10090-10107
The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms has led to significant interest in discovering selective Jak2 inhibitors for use in treating these disorders. A high-throughput screening effort identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38641cff96060895c55ccc721612a54
https://doi.org/10.1021/jm3012239
https://doi.org/10.1021/jm3012239
Autor:
Helen C. Hailes, Alethea B. Tabor, John B. Wong, Stephen L. Hart, Parviz Ayazi Shamlou, Michele J. Writer, Christopher A. Hurley, M. Jayne Lawrence, Robin J. McAnulty, Danielle M. Copeman, Marianne Odlyha, Supti Sarkar
Publikováno v:
Journal of Liposome Research. 16:373-389
We have previously described a lipopolyplex formulation comprising a mixture of a cationic peptide with an integrin-targeting motif (K16GACRRETAWACG) and Lipofectin, a liposome consisting of DOTMA and DOPE in a 1:1 ratio. The high transfection effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5de88fd814f50c3556dec9e2fa6632
https://doi.org/10.1080/08982100600992500
https://doi.org/10.1080/08982100600992500
Autor:
Hidenobu Kanda, Adam R. Johnson, Christopher A. Hurley, Mark Zak, Yingjie Lai, Kathy Barrett, Janusz J. Kulagowski, Wade S. Blair, Jan Smith, Christine Chang, Wenqian Yang, Sue J. Sohn, Hart S. Dengler, Nicholas Lewin-Koh, Lawren C. Wu, Birong Zhang, Aihe Zhou, Karen Williams, Nico Ghilardi, Jun Liang, Pawan Bir Kohli, Calum Macleod, Steven Magnuson, Anne van Abbema
TYK2 is a JAK family protein tyrosine kinase activated in response to multiple cytokines, including type I IFNs, IL-6, IL-10, IL-12, and IL-23. Extensive studies of mice that lack TYK2 expression indicate that the IFN-α, IL-12, and IL-23 pathways, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004314f8e104cfae5a1bf2ac2f051b6
https://europepmc.org/articles/PMC3748334/
https://europepmc.org/articles/PMC3748334/
Autor:
Kathy Barrett, Paul Gibbons, Steven Shia, Jane R. Kenny, Mark Zak, Charles Ellwood, Sharada Labadie, Richard James Bull, Chris Hamman, Peter H. Crackett, Peter Gribling, Peter S. Dragovich, Scott Savage, Jiangpeng Liao, Jason DeVoss, Christine Chang, Paroma Chakravarty, Mercedesz Balazs, Wyne P. Lee, Tony Johnson, Rebecca Pulk, Michael F. T. Koehler, Gauri Deshmukh, Marya Liimatta, Janusz J. Kulagowski, Pawan Bir Kohli, Anne van Abbema, Austin John Reeve, Rohan Mendonca, Adam R. Johnson, Ignacio Aliagas, Simon Gaines, Charles Eigenbrot, Yisong Xiao, Nico Ghilardi, Jing Yang, Christopher A. Hurley, Philippe Bergeron, Wade S. Blair, Peter Hewitt, Stuart Ward, Eric Harstad, Micah Steffek, Barbara Avitabile-Woo, Stefan Gradl, Raman Narukulla, Savita Ubhayakar
Publikováno v:
Journal of medicinal chemistry. 56(11)
Herein we report on the structure-based discovery of a C-2 hydroxyethyl moiety which provided consistently high levels of selectivity for JAK1 over JAK2 to the imidazopyrrolopyridine series of JAK1 inhibitors. X-ray structures of a C-2 hydroxyethyl a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d0d607376d7e1e01099fe1e9376df8
https://pubmed.ncbi.nlm.nih.gov/23659214
https://pubmed.ncbi.nlm.nih.gov/23659214
Autor:
Adam R. Johnson, Raman Narukulla, Janusz J. Kulagowski, Robert James Maxey, Rina Fong, Stuart Ward, Wade S. Blair, Hazel Joan Dyke, Jane R. Kenny, Marya Liimatta, Nico Ghilardi, Mark Zak, Patrick J. Lupardus, Christopher A. Hurley, Paul Gibbons, Rebecca Pulk, Richard James Bull, Pawan Bir Kohli, Peter H. Crackett, Christine Chang, Savita Ubhayakar, Anne van Abbema, Peter Hewitt, Bohdan Waszkowycz, Gauri Deshmukh, Tony Johnson, Rohan Mendonca
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(12)
The identification of a novel fused triazolo-pyrrolopyridine scaffold, optimized derivatives of which display nanomolar inhibition of Janus kinase 1, is described. Prototypical example 3 demonstrated lower cell potency shift, better permeability in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5dd453bc11f612af005089b1b8eb7f
https://pubmed.ncbi.nlm.nih.gov/23642482
https://pubmed.ncbi.nlm.nih.gov/23642482