Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Christopher A. Hewson"'
Autor:
Christopher R. Hewson, Joanne Aberdeen
Publikováno v:
2018 IEEE Applied Power Electronics Conference and Exposition (APEC).
Rogowski current transducers are often used to measure transient and pulsed currents in power electronic applications. They are small, clip-around and flexible making them easy to insert in circuits with a high power density, have a wide-bandwidth, a
Autor:
Peter G. Dodd, Thomas Ryckmans, Samantha Hughes, David G. Brown, Martin P. Green, Andrew Simon Bell, Willem P. van Hoorn, Christopher A. Hewson, Christopher Phillips, Philip Cohen, Lyn H. Jones, Iain Kilty, Robert T. Smith
Publikováno v:
Chemical Biology & Drug Design. 82:500-505
The first example of an inhibitor of the kinase TAK1 that binds in the DFG-out conformation is disclosed. These preliminary studies used kinase-targeted screening and structure-based drug design to create a molecule with dual pharmacological inhibiti
Autor:
Alice Jardine, Michael R. Edwards, Sebastian L. Johnston, Vasile Laza-Stanca, Christopher A. Hewson
Publikováno v:
Journal of Virology. 79:12273-12279
Rhinoviruses (RV) are the major cause of the common cold and acute exacerbations of asthma and chronic obstructive pulmonary disease. Toll-like receptors (TLRs) are a conserved family of receptors that recognize and respond to a variety of pathogen-a
Autor:
Joseph A. Dybowski, Michael Yeadon, Paul Alan Glossop, Edouard Guillabert, Toby A. Payne-Cook, David S. Millan, Craig K. Fulton, Christopher A. Hewson, Emmanuelle R. Renery, Rhys M. Jones, Matthew D. Selby, Sara Chunn, Michelle F. Tutt, Stephen Ballard, David J. Lamb, Carolyn Napier
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
In this Letter we present data for a novel series of ICS for the treatment of asthma. 'Inhalation by design' principles have been applied to a series of highly potent steroidal GR agonists, with a focus on optimising the potential therapeutic index i
Autor:
Luminita A. Stanciu, Simon D. Message, Peter K. Jeffery, JJ Haas, Michael R. Edwards, Christopher A. Hewson, M.R. Edbrooke, Vasile Laza-Stanca, Jie Zhu, Tatiana Kebadze, Onn Min Kon, Gaetano Caramori, Nathan W. Bartlett, Sebastian L. Johnston, Alberto Papi
Publikováno v:
The European respiratory journal. 36(6)
Rhinovirus (RV) infections are the major cause of asthma exacerbations, the major cause of morbidity and mortality in asthma. MUC5AC is the major mucin produced by bronchial epithelial cells. Whether RV infection upregulates MUC5AC in vivo is unknown
Autor:
Clarisse Dubray, Rhys M. Jones, Derek P. Winslow, Christopher A. Hewson, Michael Yeadon, Stephen Ballard
Publikováno v:
C33. ANTI-INFLAMMATORY STRATEGIES IN AIRWAYS DISEASE: ANIMAL MODELS.
Publikováno v:
2010 Twenty-Fifth Annual IEEE Applied Power Electronics Conference and Exposition (APEC).
Electrostatic interference through capacitive coupling onto a Rogowski coil causes unwanted pick-up noise on the output of the integrator. An electrostatic screen fitted to a Rogowski coil reduces this interference. This paper discusses how to maximi
Publikováno v:
D33. ASTHMA THERAPEUTICS -- STUDIES IN ANIMAL MODELS.
Autor:
Vasile Laza-Stanca, Hoy-Tsun H. Lau, Naofumi Mukaida, Michael R. Edwards, Marc B. Hershenson, Sebastian L. Johnston, Christopher A. Hewson
Publikováno v:
Molecular immunology. 44(7)
Rhinovirus infections cause the majority of acute exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease, with increased pro-inflammatory cytokine production by infected bronchial epithelial cells contributing to di
Publikováno v:
Twenty-First Annual IEEE Applied Power Electronics Conference and Exposition, 2006. APEC '06..
Rogowski current transducers combine a high bandwidth, an easy to use thin flexible coil, and low insertion impedance making them an ideal device for measuring pulsed currents in power electronic applications. Practical verification of a Rogowski tra