Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Christopher A. Hedges"'
Autor:
Randall F. D'Souza, Vandre C. Figueiredo, James F. Markworth, Nina Zeng, Christopher P. Hedges, Llion A. Roberts, Truls Raastad, Jeff S. Coombes, Jonathan M. Peake, Cameron J. Mitchell, David Cameron‐Smith
Publikováno v:
Physiological Reports, Vol 11, Iss 15, Pp n/a-n/a (2023)
Abstract Cold water immersion (CWI) following intense exercise is a common athletic recovery practice. However, CWI impacts muscle adaptations to exercise training, with attenuated muscle hypertrophy and increased angiogenesis. Tissue temperature mod
Externí odkaz:
https://doaj.org/article/d4749583231e4aa299375a45a732ef07
Autor:
Stewart W. C. Masson, Waruni C. Dissanayake, Sophie C. Broome, Christopher P. Hedges, Wouter M. Peeters, Martin Gram, David S. Rowlands, Peter R. Shepherd, Troy L. Merry
Publikováno v:
Physiological Reports, Vol 11, Iss 4, Pp n/a-n/a (2023)
Abstract A central characteristic of insulin resistance is the impaired ability for insulin to stimulate glucose uptake into skeletal muscle. While insulin resistance can occur distal to the canonical insulin receptor‐PI3k‐Akt signaling pathway,
Externí odkaz:
https://doaj.org/article/0f3992d53ffb40488d95e17febf0a71a
Autor:
Chantal A. Pileggi, Christopher P. Hedges, Randall F. D’Souza, Brenan R. Durainayagam, Nina Zeng, Vandre C. Figueiredo, Anthony J. R. Hickey, Cameron J. Mitchell, David Cameron-Smith
Publikováno v:
European Journal of Applied Physiology. 123:249-260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e42892e779a85c5b33ea1a53628b7cb
https://doi.org/10.1007/s00421-022-05107-x
https://doi.org/10.1007/s00421-022-05107-x
Autor:
Randall F. D'Souza, Nina Zeng, James F. Markworth, Vandre C. Figueiredo, Christopher P. Hedges, Aaron C. Petersen, Paul A. Della Gatta, David Cameron-Smith, Cameron J. Mitchell
Publikováno v:
Frontiers in Nutrition, Vol 6 (2019)
Progressive muscle loss with aging results in decreased physical function, frailty, and impaired metabolic health. Deficits in anabolic signaling contribute to an impaired ability for aged skeletal muscle to adapt in response to exercise and protein
Externí odkaz:
https://doaj.org/article/5ed325ef4cfd497bbe0d85797a0fd799
Autor:
Jules B. L. Devaux, Christopher P. Hedges, Nigel Birch, Neill Herbert, Gillian M. C. Renshaw, Anthony J. R. Hickey
Publikováno v:
Frontiers in Physiology, Vol 9 (2019)
The vertebrate brain is generally very sensitive to acidosis, so a hypoxia-induced decrease in pH is likely to have an effect on brain mitochondria (mt). Mitochondrial respiration (JO2) is required to generate an electrical gradient (ΔΨm) and a pH
Externí odkaz:
https://doaj.org/article/bcf0e336f7a6442691a0eafd0a400902
Autor:
Christopher P. Hedges, Jordi Boix, Jagdish K. Jaiswal, Bhoopika Shetty, Peter R. Shepherd, Troy L. Merry
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 150 (2021)
BYL719 (alpelisib) is a small molecule inhibitor of PI3K p110α developed for cancer therapy. Targeted suppression of PI3K has led to lifespan extension in rodents and model organisms. If PI3K inhibitors are to be considered as an aging therapeutic,
Externí odkaz:
https://doaj.org/article/fb625d826df24446bf6da1359a25b651
Autor:
Subhajit Konar, Christopher P Hedges, Karen E Callon, Scott Bolam, Sophia Leung, Jillian Cornish, Dorit Naot, David S Musson
Clinically, there is a positive correlation between BMI and the risk of tendinopathy. However, the underlying mechanisms are not understood. Dyslipidaemia and increased circulating free fatty acids (FFA) are associated with increased BMI. We hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97e379167f5d0ac911f6feb2800d1b6
https://doi.org/10.1101/2023.02.08.527761
https://doi.org/10.1101/2023.02.08.527761
Autor:
Samuel L. James, Jonathan S. T. Woodhead, Troy L. Merry, Stewart W. C. Masson, Randall F. D'Souza, Christopher P. Hedges, Caitlin MacRae
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 321:E560-E570
Neutrophils accumulate in insulin-sensitive tissues during obesity and may play a role in impairing insulin sensitivity. The major serine protease expressed by neutrophils is neutrophil elastase (NE), which is inhibited endogenously by α1-antitrypsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99667fe6826c6c37355cc6b670b666cb
https://doi.org/10.1152/ajpendo.00181.2021
https://doi.org/10.1152/ajpendo.00181.2021
Autor:
Rodrigo S. F. Oliveira, David Bishop, Adriano Eduardo Lima-Silva, Xu Yan, Cesare Granata, Alessandra Ferri, Christopher P. Hedges, Jujiao Kuang, François Billaut
Publikováno v:
European Journal of Applied Physiology. 121:2323-2336
To investigate within the one study potential molecular and cellular changes associated with mitochondrial biogenesis following 15 days of exposure to moderate hypoxia. Eight males underwent a muscle biopsy before and after 15 days of hypoxia exposur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a0542541df5831610b4bfd3eeeb64d9
https://doi.org/10.1007/s00421-021-04706-4
https://doi.org/10.1007/s00421-021-04706-4
Autor:
Christopher P. Hedges, Troy L. Merry
Publikováno v:
Oxidative Eustress in Exercise Physiology ISBN: 9781003051619
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b464315bc566eabd433543c38a716655
https://doi.org/10.1201/9781003051619-5
https://doi.org/10.1201/9781003051619-5