Zobrazeno 1 - 10
of 858
pro vyhledávání: '"Christopher A. Browne"'
Autor:
Joanna Schneider, Christopher A. Browne, Malcolm Slutzky, Cecilia A. Quirk, Daniel B. Amchin, Sujit S. Datta
Publikováno v:
Physical Review Research, Vol 5, Iss 4, p 043015 (2023)
Drainage, in which a nonwetting fluid displaces a wetting fluid from a porous medium, is well studied for media with unchanging solid surfaces. However, many media can be eroded by drainage, with eroded material redeposited in pores downstream, alter
Externí odkaz:
https://doaj.org/article/e44b55e0597e4ebda6cc22700dfa7132
Publikováno v:
Frontiers in Physics, Vol 9 (2021)
Models of disease spreading are critical for predicting infection growth in a population and evaluating public health policies. However, standard models typically represent the dynamics of disease transmission between individuals using macroscopic pa
Externí odkaz:
https://doaj.org/article/538c26efa8c64dcca094aa65cd971cdb
Publikováno v:
Journal of Fluid Mechanics. 963
Many key environmental, industrial and energy processes rely on controlling fluid transport within subsurface porous media. These media are typically structurally heterogeneous, often with vertically layered strata of distinct permeabilities – lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9323ceda6bac5851e3b12990886b075
https://doi.org/10.1017/jfm.2023.337
https://doi.org/10.1017/jfm.2023.337
Autor:
Kun Ping Lu, Hyuk-Soo Seo, Yujin Chun, Christopher M. Browne, Theresa D. Manz, Xiao Zhen Zhou, Zainab M. Doctor, Xiaolan Lian, Zoe C. Yeoh, Shin Kibe, Scott B. Ficarro, Nir London, Benika J. Pinch, Nicholas E. Vangos, Behnam Nabet, Stephen Buratowski, Dina Daitchman, Shingo Kozono, Daniel Zaidman, Nathanael S. Gray, Jarrod A. Marto, Mikaela L. Mohardt, Li Tan, Sirano Dhe-Paganon, Ezekiel A. Geffken
Publikováno v:
Nature chemical biology
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in human cancers, including pancreatic ductal adenocarcinoma (PDAC). While Pin1 is dispensable for viability in mice, it is required for activated Ras to induce t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565cbd6de180dcf92ba1d74b5e545e0
https://doi.org/10.1038/s41589-020-0550-9
https://doi.org/10.1038/s41589-020-0550-9
Autor:
Christopher A. Browne, Sujit S. Datta
Publikováno v:
Science Advances
Description
Microscopy reveals that polymers cause chaotic flow fluctuations in a porous medium, increasing macroscopic flow resistance.
Many energy, environmental, industrial, and microfluidic processes rely on the flow of polymer solution
Microscopy reveals that polymers cause chaotic flow fluctuations in a porous medium, increasing macroscopic flow resistance.
Many energy, environmental, industrial, and microfluidic processes rely on the flow of polymer solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e16eb064e5eb8571ee6e5b0a8f4547
https://doi.org/10.1126/sciadv.abj2619
https://doi.org/10.1126/sciadv.abj2619
Publikováno v:
Physical Review Fluids. 6
The accumulation of stresses as polymeric chains cross successive pores creates streaks of high polymeric stress. Highly stretched polymeric chains in the regions of high polymeric stress resist the flow crossing these streaks, leading to eddy format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3d1736efe4eb92a60940fc83a415dc
https://doi.org/10.1103/physrevfluids.6.033304
https://doi.org/10.1103/physrevfluids.6.033304
Autor:
Joachim Frank, Bingxin Shen, Wen Li, Parimal Samir, Ming Sun, Andrew J. Link, Christopher M. Browne
Publikováno v:
Proteomics. 21(2)
The role of the ribosome in the regulation of gene expression has come into increased focus. It has been proposed that ribosomes are catalytic engines capable of changing their protein composition in response to environmental stimuli. We employed tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df6d8588c38ab2c7c18ea769ea6f2a6
https://pubmed.ncbi.nlm.nih.gov/33007145
https://pubmed.ncbi.nlm.nih.gov/33007145
Autor:
Evon Poon, Anli Yang, Xiao Zhou, Efrat Resnick, Daniel Zaidman, Roni Oren, Yann Jamin, Shingo Kozono, Colin J. Daniel, Ellen M. Langer, Shijie He, Behnam Nabet, Yu-Hong Chen, Christopher M. Browne, Hyuk-Soo Seo, Louis Chesler, Kun Ping Lu, Benika J. Pinch, Rosalie C. Sears, Shin Kibe, Liat Stoler-Barak, Ziv Shulman, Nir London, Samuel Sidi, Christian Dubiella, Thomas Look, Nicholas E. Vangos, Kazuhiro Koikawa, Xiaolan Lian, Chunhui Wang, Nathaniel Gray, Trevor Manz, Jarrod A. Marto, Richa B. Shah, Ezekiel A. Geffken, Sirano Dhe-Paganon, Scott B. Ficarro
The peptidyl-prolyl cis-trans isomerase, Pin1, acts as a unified signaling hub that is exploited in cancer to activate oncogenes and inactivate tumor suppressors, in particular through up-regulation of c-Myc target genes. However, despite considerabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3ceb5d0f3a7e590d161df59af1ffd9
https://doi.org/10.1101/2020.03.20.998443
https://doi.org/10.1101/2020.03.20.998443
Autor:
Sirano Dhe-Paganon, Benika J. Pinch, Mark W. Zimmerman, Richa B. Shah, Kun Ping Lu, Jarrod A. Marto, Shuning He, Eriko Koide, Daniel Zaidman, Christopher M. Browne, Ziv Shulman, Barbara Martins da Costa, Christian Dubiella, Evon Poon, Guillaume Adelmant, Nir London, Xiao Zhen Zhou, Chu Wang, Ellen M. Langer, Kazuhiro Koikawa, Theresa D. Manz, Thomas Look, Xiaolan Lian, Hyuk-Soo Seo, Annan Yang, Louis Chesler, Ezekiel A. Geffken, Liat Stoler-Barak, Shin Kibe, Efrat Resnick, Nicholas E. Vangos, Shabnam Sharifzadeh, Shingo Kozono, Colin J. Daniel, Scott B. Ficarro, Roni Oren, Ying Chen, Nathanael S. Gray, Rosalie C. Sears, Samuel Sidi, Adi Rogel, Zainab M. Doctor, Behnam Nabet, Yann Jamin
Publikováno v:
Nat Chem Biol
The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Here, we screened an electrophilic fragment library t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8338cdca0db7efbd0dc3ed699641997f
https://pubmed.ncbi.nlm.nih.gov/34040180
https://pubmed.ncbi.nlm.nih.gov/34040180
Autor:
Howard A. Stone, Nancy B. Lu, Amir Pahlavan, Daniel B. Amchin, Christopher A. Browne, Sujit S. Datta
Imbibition plays a central role in diverse energy, environmental, and industrial processes. In many cases, the medium has multiple parallel strata of different permeabilities; however, how this stratification impacts imbibition is poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99ff5a80488ab4c74f91857e5f4b763