Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Christopher A. Benetatos"'
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
The acquisition of apoptosis resistance is a fundamental event in cancer development. Among the mechanisms used by cancer cells to evade apoptosis is the dysregulation of inhibitor of apoptosis (IAP) proteins. The activity of the IAPs is regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749eac6e33c3d6ae4c15d5416ec41d41
https://doi.org/10.1158/1535-7163.c.6536442.v1
https://doi.org/10.1158/1535-7163.c.6536442.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
PDF file - 1384KB, Supplemental Figure 1. Structure of biotinylated birinapant Supplemental Figure 2. Concentration-dependent degradation of GFP-cIAP1/2 by birinapant Supplemental Figure 3. Representative examples of data analysis from 111 cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cfd31d3e0c71e37181fc6d9362974f
https://doi.org/10.1158/1535-7163.22500405.v1
https://doi.org/10.1158/1535-7163.22500405.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
PDF file - 73KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6017e6fd5bb940ccaf18ea18c0384148
https://doi.org/10.1158/1535-7163.22500408.v1
https://doi.org/10.1158/1535-7163.22500408.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
XLS file - 45KB, Sensitivity of a 111 cell line panel to birinapant as a single agent and in combination with TNF or TRAIL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a5608cfd12aa98c693523b28ad5a19
https://doi.org/10.1158/1535-7163.22500402.v1
https://doi.org/10.1158/1535-7163.22500402.v1
Autor:
Randy W. Jackson, Matthew G. LaPorte, Torsten Herbertz, Tandy L. Draper, Janet A. Gaboury, Susan R. Rippin, Ravi Patel, Srinivas K. Chunduru, Christopher A. Benetatos, Dorothy C. Young, Christopher J. Burns, Stephen M. Condon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3227-3231
We describe the structure-activity relationship of the C7-position of pyrano[3,4-b]indole-based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compounds 13 a
Autor:
Eugene C. Amparo, Srinivas K. Chunduru, Ariamala Gopalsamy, Christopher A. Benetatos, Lori E. Miller, Tandy L. Draper, Christopher J. Burns, Matthew G. LaPorte, Lara K. Leister, Torsten Herbertz, Dorothy C. Young, Stephen M. Condon, Blackledge Charles W, Gerry Rhodes, Alison R. Hussey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2968-2973
We describe the structure-activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.
Autor:
Daniel C. Pevear, Dorothy C. Young, Christopher A. Benetatos, Glen A. Coburn, Susan R. Rippin, Christopher J. Burns, Marc S. Collett, Christopher J. Rizzo, Joel S. Christensen, Tandy L. Draper, Tiejun Gao, John O'Connell, Stephen M. Condon, Kristin Galie, Alison R. Hussey, Srinivas K. Chunduru, Gerry Rhodes, Norman M. Kneteman, Janet A. Gaboury, Tarek S. Mansour, Randy W. Jackson, D. Lorne Tyrrell, Anita Y. M. Howe, Matthew G. LaPorte, Torsten Herbertz
Publikováno v:
ChemMedChem. 3:1508-1515
Autor:
John Silke, Stephen M. Condon, Christopher A. Benetatos, W. Wei-Lynn Wong, Nufail Khan, Pascal Schneider, Frank Koentgen, Bernard A. Callus, James E Vince, Mark A. McKinlay, Srinivas K. Chunduru, Diep Chau, Martin Leverkus, Afsar U. Ahmed, Vinay Tergaonkar, David L. Vaux, Rebecca Feltham, Robert Brink
Publikováno v:
Cell, vol. 131, no. 4, pp. 682-693
XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be relieved by IAP antagonists, such as Smac/DIABLO. IAP antagonist compounds (IACs) have therefore been designed to inhibit XIAP to kill tumor cells. Because XIAP
Autor:
Srinivas K. Chunduru, John W. Ellingboe, Huiming Cheng, Boris Feld, John O'Connell, Carl J. Baldick, Matthew W. Olson, Ian J. Thompson, Tarek S. Mansour, Michelle L. Kimberland, Marja van Zeijl, Girija Krisnamurthy, Christopher A. Benetatos, Joel S. Christensen, Dorothy C. Young, Ariamala Gopalsamy, Mark Orlowski, Steve Swanberg, Glen A. Coburn, Megan Thorn, Alfred M. Del Vecchio, Johnathan Bloom, Xiaoqun Jiang, S V Johann, Janis Upeslacis, Marc S. Collett, William P. Gorczyca, Anita Y. M. Howe, Steve Herrmann
Publikováno v:
Antimicrobial Agents and Chemotherapy
A novel nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), [(1 R )-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyano[3,4-b]indol-1-yl] acetic acid (HCV-371), was discovered through high-throughput screening follow
Autor:
Christopher A. Benetatos, Dorothy C. Young, Robert Jordan, Marc S. Collett, Guang Yang, Daniel C. Pevear, Srinivas K. Chunduru
Publikováno v:
Journal of Virology. 78:10202-10205
Biochemical characterization of hepatitis C virus (HCV) replication using purified, membrane-associated replication complexes is hampered by the presence of endogenous nuclease activity that copurifies with the replication complex. In this study, pul