Modelling and Molecular Dynamics Predict the Structure and Interactions of the Glycine Receptor Intracellular Domain

Autor: James R. E. Thompson, Christopher A. Beaudoin, Sarah C. R. Lummis

Publikováno v: Biomolecules, Vol 13, Iss 12, p 1757 (2023)

Glycine receptors (GlyRs) are glycine-gated inhibitory pentameric ligand-gated ion channels composed of α or α + β subunits. A number of structures of these proteins have been reported, but to date, these have only revealed details of the extracel

Externí odkaz: https://doaj.org/article/c448e54402954613ae9a81d884929d1e

Are There Hidden Genes in DNA/RNA Vaccines?

Autor: Christopher A. Beaudoin, Martin Bartas, Adriana Volná, Petr Pečinka, Tom L. Blundell

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Due to the fast global spreading of the Severe Acute Respiratory Syndrome Coronavirus – 2 (SARS-CoV-2), prevention and treatment options are direly needed in order to control infection-related morbidity, mortality, and economic losses. Although dru

Externí odkaz: https://doaj.org/article/04fce1eb78dc496c94f60c9e8e4696f1

SARS-CoV-2 Omicron subvariant spike N405 unlikely to rapidly deamidate

Autor: Christopher A. Beaudoin, Emmanouela Petsolari, Samir W. Hamaia, Sharif Hala, Fadwa S. Alofi, Arun P. Pandurangan, Tom L. Blundell, Sundeep Chaitanya Vedithi, Christopher L.-H. Huang, Antony P. Jackson

Publikováno v: Biochemical and Biophysical Research Communications. 666:61-67

The RGD motif on the SARS-CoV-2 spike protein has been suggested to interact with RGD-binding integrins αVβ3 and α5β1 to enhance viral cell entry and alter downstream signaling cascades. The D405N mutation on the Omicron subvariant spike proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33106946ebb34dbf0d56168230eb7b09
https://doi.org/10.1016/j.bbrc.2023.04.088

Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

Autor: Pedro H M Torres, Sharif Hala, Liviu Copoiu, Christopher A. Beaudoin, Tom L. Blundell, Ali F. Alsulami, Arian R. Jamasb, Andries J. van Tonder, Sherine E. Thomas, Bridget P. Bannerman, Sundeep Chaitanya Vedithi

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3938-3953 (2021)

SummaryViruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff7e4bdc87d686aaf05734ef6a413f8
http://www.sciencedirect.com/science/article/pii/S2001037021002798

Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA

Autor: Martin Bartas, Adriana Volná, Christopher A Beaudoin, Ebbe Toftgaard Poulsen, Jiří Červeň, Václav Brázda, Vladimír Špunda, Tom L Blundell, Petr Pečinka

Publikováno v: Bartas, M, Volná, A, Beaudoin, C A, Poulsen, E T, Červeň, J, Brázda, V, Špunda, V, Blundell, T L & Pečinka, P 2022, ' Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA ', Briefings in bioinformatics, vol. 23, no. 3, bbac045 . https://doi.org/10.1093/bib/bbac045

SARS-CoV-2 is a novel positive-sense single-stranded RNA virus from the Coronaviridae family (genus Betacoronavirus), which has been established as causing the COVID-19 pandemic. The genome of SARS-CoV-2 is one of the largest among known RNA viruses,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb4cdbcd87407b43bc05379c98c0759
https://doi.org/10.1093/bib/bbac045