Zobrazeno 1 - 10
of 1 607
pro vyhledávání: '"Christopher A. Walsh"'
Autor:
Soraia Barão, Yijun Xu, José P. Llongueras, Rachel Vistein, Loyal Goff, Kristina J. Nielsen, Byoung-Il Bae, Richard S. Smith, Christopher A. Walsh, Genevieve Stein-O’Brien, Ulrich Müller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The neocortex varies in size and complexity among mammals due to the tremendous variability in the number and diversity of neuronal subtypes across species. The increased cellular diversity is paralleled by the expansion of the pool of neoco
Externí odkaz:
https://doaj.org/article/b65bc45bf8dc45989890eae4f1d50f6b
Autor:
Ming Hui Chen, Ellen S. Deng, Jessica M. Yamada, Sangita Choudhury, Julia Scotellaro, Lily Kelley, Eric Isselbacher, Mark E. Lindsay, Christopher A. Walsh, Ryan N. Doan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 14 (2024)
Background Thoracic aortic aneurysm (TAA) is associated with significant morbidity and mortality. Although individuals with family histories of TAA often undergo clinical molecular genetic testing, adults with nonsyndromic TAA are not typically evalu
Externí odkaz:
https://doaj.org/article/882e211948344b91ba18864ae800da39
Autor:
McKinzie A. Garrison, Yeongjun Jang, Taejeong Bae, Adriana Cherskov, Sarah B. Emery, Liana Fasching, Attila Jones, John B. Moldovan, Cindy Molitor, Sirisha Pochareddy, Mette A. Peters, Joo Heon Shin, Yifan Wang, Xiaoxu Yang, Schahram Akbarian, Andrew Chess, Fred H. Gage, Joseph G. Gleeson, Jeffrey M. Kidd, Michael McConnell, Ryan E. Mills, John V. Moran, Peter J. Park, Nenad Sestan, Alexander E. Urban, Flora M. Vaccarino, Christopher A. Walsh, Daniel R. Weinberger, Sarah J. Wheelan, Alexej Abyzov, BSMN Consortium
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-18 (2023)
Abstract Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that p
Externí odkaz:
https://doaj.org/article/169288af9ac84d8b8a7875b0a5f4336c
Autor:
Manal Alaamery, Salam Massadeh, Manar Aldarwish, Nour Albesher, Nora Aljawini, Othman Alahmed, Amna Kashgari, Christopher A. Walsh, Wafaa Eyaid
Publikováno v:
Frontiers in Genetics, Vol 14 (2024)
Congenital disorders of glycosylation (CDG) are a group of more than 100 rare genetic disorders characterized by impaired glycosylation of proteins and lipids. The clinical presentation of CDG varies tremendously, from single-organ to multi-organ inv
Externí odkaz:
https://doaj.org/article/19c2de1afdd347e8b4a8a8815e3c9f16
Publikováno v:
Ecosphere, Vol 14, Iss 12, Pp n/a-n/a (2023)
Abstract Riffles are heterogeneous habitats that support diverse assemblages in natural streams. They are often constructed as part of stream restoration practice, including in degraded urban stream ecosystems, despite larger scale limits to ecologic
Externí odkaz:
https://doaj.org/article/58bd73d2a76d46a8a9057b4f6d9af070
Autor:
Junho Kim, August Yue Huang, Shelby L. Johnson, Jenny Lai, Laura Isacco, Ailsa M. Jeffries, Michael B. Miller, Michael A. Lodato, Christopher A. Walsh, Eunjung Alice Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
DNA damage has been implicated in aging and neurodegeneration. Here, the authors develop a bioinformatic method to detect deletions in single neuron genome sequences and reveal an increased burden of somatic deletions during aging and in DNA repair d
Externí odkaz:
https://doaj.org/article/162ddeb312a542bf86be9477a455f1cc
Autor:
Ajay X. Thomas, Nichole Link, Laurie A. Robak, Gail Demmler‐Harrison, Emily C. Pao, Audrey E. Squire, Savannah Michels, Julie S. Cohen, Anne Comi, Paolo Prontera, Alberto Verrotti di Pianella, Giuseppe Di Cara, Livia Garavelli, Stefano Giuseppe Caraffi, Carlo Fusco, Roberta Zuntini, Kendall C. Parks, Elliott H. Sherr, Mais O. Hashem, Sateesh Maddirevula, Fowzan S. Alkuraya, Isphana A. F. Contractar, Jennifer E. Neil, Christopher A. Walsh, Hugo J. Bellen, Hsiao‐Tuan Chao, Robin D. Clark, Ghayda M. Mirzaa
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 8, Pp 1276-1288 (2022)
Abstract Objective This study delineates the clinical and molecular spectrum of ANKLE2‐related microcephaly (MIC), as well as highlights shared pathological mechanisms between ANKLE2 and the Zika virus. Methods We identified 12 individuals with MIC
Externí odkaz:
https://doaj.org/article/bf3759a0566147bbb6315854302293ea
Autor:
Elaine T. Lim, Yingleong Chan, Pepper Dawes, Xiaoge Guo, Serkan Erdin, Derek J. C. Tai, Songlei Liu, Julia M. Reichert, Mannix J. Burns, Ying Kai Chan, Jessica J. Chiang, Katharina Meyer, Xiaochang Zhang, Christopher A. Walsh, Bruce A. Yankner, Soumya Raychaudhuri, Joel N. Hirschhorn, James F. Gusella, Michael E. Talkowski, George M. Church
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Cerebral organoids can be used to gain insights into neuropsychiatric disorders. Here the authors carry out RNAseq characterization from organoids derived from donors with autism spectrum disorder to identify associated cell type specific driver gene
Externí odkaz:
https://doaj.org/article/95de5f4e0e584e9ba9efd47fbab020ce
MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness
Autor:
Christopher J. Walsh, Carlos Escudero King, Muskan Gupta, Pamela J. Plant, Margaret J. Herridge, Sunita Mathur, Pingzhao Hu, Judy Correa, Sameen Ahmed, Anne Bigot, Claudia C. dosSantos, Jane Batt, Submitted on behalf of the MusclE and Nerve Dysfunction (MEND)‐ICU Group and Canadian Critical Care Translational Biology Group (CCCTBG)
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1262-1276 (2022)
Abstract Background Intensive care unit (ICU)‐acquired weakness is characterized by muscle atrophy and impaired contractility that may persist after ICU discharge. Dysregulated muscle repair and regeneration gene co‐expression networks are presen
Externí odkaz:
https://doaj.org/article/f8215a3d765742de99fa1db9d3550ea5
Autor:
Rebeca Borges-Monroy, Chong Chu, Caroline Dias, Jaejoon Choi, Soohyun Lee, Yue Gao, Taehwan Shin, Peter J. Park, Christopher A. Walsh, Eunjung Alice Lee
Publikováno v:
Mobile DNA, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract Background Retrotransposons have been implicated as causes of Mendelian disease, but their role in autism spectrum disorder (ASD) has not been systematically defined, because they are only called with adequate sensitivity from whole genome s
Externí odkaz:
https://doaj.org/article/8f9cee324ba7466e90e75f9ca6ee92f3