Zobrazeno 1 - 10
of 634
pro vyhledávání: '"Christopher A Ross"'
Autor:
Elaine Waldron-Roby, Janine Hoerauf, Nicolas Arbez, Shanshan Zhu, Kirsten Kulcsar, Christopher A Ross
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141439 (2015)
The apoptotic cascade is an orchestrated event, whose final stages are mediated by effector caspases. Regulatory binding proteins have been identified for caspases such as caspase-3, -7, -8, and -9. Many of these proteins belong to the inhibitor of a
Externí odkaz:
https://doaj.org/article/089345109c2040cb96afee68de706957
Autor:
Rui eWang, Christopher A Ross, Huan eCai, Wei-na eCong, Caitlin M Daimon, Olga D Carlson, Josephine M Egan, Sana eSiddiqui, Stuart eMaudsley, Bronwen eMartin
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Huntington's disease (HD) is an inherited neurodegenerative disorder typified by involuntary body movements, and psychiatric and cognitive abnormalities. Many HD patients also exhibit metabolic changes including progressive weight loss and appetite d
Externí odkaz:
https://doaj.org/article/daef487d9028465d899217a28b158bca
Autor:
Jane S Paulsen, Jeffrey D Long, Hans J Johnson, Elizabeth H Aylward, Christopher A Ross, Janet K Williams, Martha A Nance, Cheryl J Erwin, Holly K Westervelt, Deborah Lynn Harrington, H Jeremy Bockholt, Ying eZhang, Elizabeth A McCusker, Edmund M Chiu, Peter K Panegyres
Publikováno v:
Frontiers in Aging Neuroscience, Vol 6 (2014)
There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinic
Externí odkaz:
https://doaj.org/article/0e6713759429493c887533d49fd6d3e9
Autor:
Erin E Watkin, Nicolas Arbez, Elaine Waldron-Roby, Robert O'Meally, Tamara Ratovitski, Robert N Cole, Christopher A Ross
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88284 (2014)
Phosphorylation has been shown to have a significant impact on expanded huntingtin-mediated cellular toxicity. Several phosphorylation sites have been identified on the huntingtin (Htt) protein. To find new potential therapeutic targets for Huntingto
Externí odkaz:
https://doaj.org/article/a760bb87c312433792c9a180b917b4e7
Publikováno v:
HTS Teologiese Studies/Theological Studies, Vol 78, Iss 4, Pp e1-e10 (2022)
Working within the sensing, intuition, feeling, thinking (SIFT) approach to biblical hermeneutics, the present study focuses attention on the distinctive voices of introverted intuition and extraverted intuition, by analysing the way in which two sma
Externí odkaz:
https://doaj.org/article/181f0f6a39bf43b3b28e4b2ffa3472bc
Autor:
Jinru Zhang, Kai Li, Xiaobo Wang, Amber M. Smith, Bo Ning, Zhaohui Liu, Chunfeng Liu, Christopher A. Ross, Wanli W. Smith
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Mutations in leucine-rich repeat kinase 2 gene (LRRK2) are the most frequent genetic factors contributing to Parkinson's disease (PD). G2385R-LRRK2 increases the risk for PD susceptibility in the Chinese population. However, the pathological role of
Externí odkaz:
https://doaj.org/article/eb7cb181d6e848339e64e01118dd5ea4
Autor:
Chelsy R. Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R. Hayden, Christopher A. Ross
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 118-129 (2019)
Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein with a polyglutamine expansion. There is preferential loss of medium spiny neurons within the
Externí odkaz:
https://doaj.org/article/6c7c6a1004604c76b60f2b97bd104cc6
Autor:
Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández, Rogan A. Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A. Ross, Udai B. Pandey, José J. Lucas, Frédéric Saudou, Maria Pennuto, Manuela Basso
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108980- (2021)
Summary: The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disru
Externí odkaz:
https://doaj.org/article/4ec24cea628a418d9972d9f2b7afcdb5
Publikováno v:
HTS Teologiese Studies/Theological Studies, Vol 76, Iss 1, Pp e1-e10 (2020)
Psalm 73 is a challenging Psalm in which the Psalmist draws on rich imagery to juxtapose doctrine and experience and to juxtapose the goodness of God with divine retribution. Drawing on data provided by 15 theological educators within the Anglican Di
Externí odkaz:
https://doaj.org/article/1050fb21619e4f7ab6fc2ccbd7a24409
Autor:
Xiaobo Wang, Tengteng Wu, Jinru Zhang, Gongbo Guo, XiaoFei He, Zhong Pei, Zhaohui Liu, Chun-feng Liu, Christopher A. Ross, Wanli W. Smith
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Mutations in transmembrane protein 230 (TMEM230) gene are suggested to be associated with the autosomal dominant Parkinson’s disease (PD) with typical movement disorders and Lewy body pathology. However, the normal functions and the pathological ro
Externí odkaz:
https://doaj.org/article/aadc308d88524e669e9e89ca13629bf9