Zobrazeno 1 - 10
of 723
pro vyhledávání: '"Christopher A Marshall"'
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
IntroductionPredators, such as sharks, play important ecological roles in coastal ecosystems when abundant and these roles change over ontogeny. However, these shifts in ecological role are often not evaluated in light of feeding performance. Bite fo
Externí odkaz:
https://doaj.org/article/cc5c597d8c3141dcabf189755b392f14
Autor:
Yasmin Hilliam, Catherine R. Armbruster, Glenn J. Rapsinski, Christopher W. Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Vaughn S. Cooper, Stella E. Lee, Jennifer M. Bomberger
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Elexacaftor/tezacaftor/ivacaftor (ETI) therapy has revolutionized the treatment of cystic fibrosis (CF) for most affected individuals but the effects of treatment on sinus microbiota are still unknown. Changes to the airway microbiota in CF
Externí odkaz:
https://doaj.org/article/5a3bbce938e54649ad18e4450997e4d3
Autor:
Sonal V. Gidwani, Devarshi Brahmbhatt, Aaron Zomback, Mamie Bassie, Jennifer Martinez, Jian Zhuang, John Schulze, Jason S. McLellan, Roberto Mariani, Peter Alff, Daniela Frasca, Bonnie B. Blomberg, Christopher P. Marshall, Mark A. Yondola
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Viral fusion proteins facilitate cellular infection by fusing viral and cellular membranes, which involves dramatic transitions from their pre- to postfusion conformations. These proteins are among the most protective viral immunogens, but t
Externí odkaz:
https://doaj.org/article/9f64bc085d664e7cb563be6d97f3ebf8
Autor:
Teklab Gebregiworgis, Jonathan Yui-Lai Chan, Douglas A. Kuntz, Gilbert G. Privé, Christopher B. Marshall, Mitsuhiko Ikura
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151414- (2024)
The RAS isoforms (KRAS, HRAS and NRAS) have distinct cancer type-specific profiles. NRAS mutations are the second most prevalent RAS mutations in skin and hematological malignancies. Although RAS proteins were considered undruggable for decades, isof
Externí odkaz:
https://doaj.org/article/3a8df14dd4c348f6b90cd509a98b511e
Autor:
Catherine R. Armbruster, Yasmin K. Hilliam, Anna C. Zemke, Samar Atteih, Christopher W. Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Stella E. Lee, Vaughn S. Cooper, Jennifer M. Bomberger
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTToday, more than 90% of people with cystic fibrosis (pwCF) are eligible for the highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy called elexacaftor/tezacaftor/ivacaftor (ETI) and its use is widespr
Externí odkaz:
https://doaj.org/article/e81a565677104a8fb1a34e72ff5752ba
Autor:
Gaurav Majumdar, Timothy A Liddle, Calum Stewart, Christopher J Marshall, Maureen Bain, Tyler Stevenson
Publikováno v:
eLife, Vol 12 (2023)
Annual cycles in daylength provide an initial predictive environmental cue that plants and animals use to time seasonal biology. Seasonal changes in photoperiodic information acts to entrain endogenous programs in physiology to optimize an animal’s
Externí odkaz:
https://doaj.org/article/7a26ec1f2bfb461a96454355dd70b0a6
Autor:
Clare M. Fieseler, Nadia Al-Mudaffar Fawzi, Brian Helmuth, Alexandra Leitão, Mehsin Al Ainsi, Mohammad Al Mukaimi, Mohammad Al-Saidi, Fahad Al Senafi, Ivonne Bejarano, Radhouan Ben-Hamadou, Josh D'Addario, Ahmad Mujthaba Dheen Mohamed, Bruno W. Giraldes, Lyle Glowka, Maggie D. Johnson, Brett P. Lyons, Daniel Mateos-Molina, Christopher D. Marshall, Sayeed Mohammed, Pedro Range, Mohammad Reza Shokri, John M. K. Wong, Nicholas D. Pyenson
Publikováno v:
Royal Society Open Science, Vol 10, Iss 9 (2023)
The ecological state of the Persian or Arabian Gulf (hereafter ‘Gulf') is in sharp decline. Calls for comprehensive ecosystem-based management approaches and transboundary conservation have gone largely unanswered, despite mounting marine threats m
Externí odkaz:
https://doaj.org/article/02f74c81b1ee4138b55c32c23bf250f2
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Temperate zone animals exhibit seasonal variation in multiple endocrine systems. In most cases, peripheral organs display robust switches in tissue involution and recrudescence in mass. Our understanding of the molecular control of tissue-sp
Externí odkaz:
https://doaj.org/article/163ab89c3e724d688802ce683ef6df7d
Publikováno v:
Royal Society Open Science, Vol 10, Iss 4 (2023)
The feeding apparatus of sea turtles comprises cornified keratinous rhamphothecae overlaying a bony rostrum. Although keratin is less stiff than the enamel of toothed animals, certain species of sea turtles are capable of withstanding large forces wh
Externí odkaz:
https://doaj.org/article/fb6275968c524095bae5ed9099613890
Autor:
Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L. Udaskin, Ahmet Mentes, Richard Huang, Betty P. K. Poon, Wenguang He, Ivette Valencia-Sama, Claire M. Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S. Irwin, Jeffrey E. Lee, Ming-Sound Tsao, Brian Raught, Christopher B. Marshall, Michael Ohh, Mitsuhiko Ikura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SHP2 promotes RAS-driven MAPK signalling, but it is unclear why cancer cells with distinct KRAS mutations exhibit differential sensitivity to SHP2 inhibition. Here the authors show that KRAS Q61H is decoupled from SHP2- mediated upstream regulation,
Externí odkaz:
https://doaj.org/article/adc5eaa39af340409424aef1fcf1144b