Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Christopher A MacRaild"'
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 11 (2022)
Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required
Externí odkaz:
https://doaj.org/article/0679868db9304f46bdc0d01432a2d431
Autor:
Andrew J Guy, Vashti Irani, Christopher A MacRaild, Robin F Anders, Raymond S Norton, James G Beeson, Jack S Richards, Paul A Ramsland
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141729 (2015)
Malaria remains a significant global health burden. The development of an effective malaria vaccine remains as a major challenge with the potential to significantly reduce morbidity and mortality. While Plasmodium spp. have been shown to contain a la
Externí odkaz:
https://doaj.org/article/c7c5fab96dec4236ad0ea25ee3ede530
Autor:
Christopher A MacRaild, Milan Zachrdla, Dean Andrew, Bankala Krishnarjuna, Jiří Nováček, Lukáš Žídek, Vladimír Sklenář, Jack S Richards, James G Beeson, Robin F Anders, Raymond S Norton
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119899 (2015)
Merozoite surface protein 2 (MSP2) of Plasmodium falciparum is an abundant, intrinsically disordered protein that is GPI-anchored to the surface of the invasive blood stage of the malaria parasite. Recombinant MSP2 has been trialled as a component of
Externí odkaz:
https://doaj.org/article/6ccae8c4810c405e905cd97c80ea7865
Autor:
Geqing Wang, Christopher A MacRaild, Biswaranjan Mohanty, Mehdi Mobli, Nathan P Cowieson, Robin F Anders, Jamie S Simpson, Sheena McGowan, Raymond S Norton, Martin J Scanlon
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109674 (2014)
Apical membrane antigen 1 (AMA1) of the human malaria parasite Plasmodium falciparum has been implicated in invasion of the host erythrocyte. It interacts with malarial rhoptry neck (RON) proteins in the moving junction that forms between the host ce
Externí odkaz:
https://doaj.org/article/a51fd55313c34feba2785836de28f0c3
Autor:
Hardik A. Jain, Vinti Agarwal, Chaarvi Bansal, Anupama Kumar, Faheem, Muzaffar-Ur-Rehman Mohammed, Sankaranarayanan Murugesan, Moana M. Simpson, Avinash V. Karpe, Rohitash Chandra, Christopher A. MacRaild, Ian K. Styles, Amanda L. Peterson, Matthew A. Cooper, Carl M. J. Kirkpatrick, Rohan M. Shah, Enzo A. Palombo, Natalie L. Trevaskis, Darren J. Creek, Seshadri S. Vasan
Publikováno v:
Data, Vol 7, Iss 11, p 164 (2022)
Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to get safe, effective, and affordable COVID-19 treatments quickly is to repurpose drugs that
Externí odkaz:
https://doaj.org/article/49b343162cba4568bab1044455839534
Autor:
Alexander J. McAuley, Petrus Jansen van Vuren, Muzaffar-Ur-Rehman Mohammed, Faheem, Sarah Goldie, Shane Riddell, Nathan J. Gödde, Ian K. Styles, Matthew P. Bruce, Simran Chahal, Stephanie Keating, Kim R. Blasdell, Mary Tachedjian, Carmel M. O’Brien, Nagendrakumar Balasubramanian Singanallur, John Noel Viana, Aditya V. Vashi, Carl M. Kirkpatrick, Christopher A. MacRaild, Rohan M. Shah, Elizabeth Vincan, Eugene Athan, Darren J. Creek, Natalie L. Trevaskis, Sankaranarayanan Murugesan, Anupama Kumar, Seshadri S. Vasan
Publikováno v:
Viruses, Vol 14, Iss 11, p 2417 (2022)
The repurposing of licenced drugs for use against COVID-19 is one of the most rapid ways to develop new and alternative therapeutic options to manage the ongoing pandemic. Given circa 7817 licenced compounds available from Compounds Australia that ca
Externí odkaz:
https://doaj.org/article/f5bfde929e31460aa993d8fbbab0208e
Autor:
Xiaofang Wang, Anna Katharina Schuh, Ghizal Siddiqui, Darren J. Creek, Jianbo Wu, Kim C. Heimsch, Yuxiang Dong, Christopher A. MacRaild, Dovile Anderson, Carlo Giannangelo, Amanda De Paoli, Jonathan L. Vennerstrom, Katja Becker, Timothy G. Brown
Publikováno v:
ACS Infectious Diseases. 8:210-226
Plasmodium falciparum causes the most lethal form of malaria. Peroxide antimalarials based on artemisinin underpin the frontline treatments for malaria, but artemisinin resistance is rapidly spreading. Synthetic peroxide antimalarials, known as ozoni
Autor:
Christopher A. MacRaild, Muzaffar-Ur-Rehman Mohammed, null Faheem, Sankaranarayanan Murugesan, Ian K. Styles, Amanda L. Peterson, Carl M. J. Kirkpatrick, Matthew A. Cooper, Enzo A. Palombo, Moana M. Simpson, Hardik A. Jain, Vinti Agarwal, Alexander J. McAuley, Anupama Kumar, Darren J. Creek, Natalie L. Trevaskis, Seshadri S. Vasan
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11851
SARS-CoV-2, is the cause of the COVID-19 pandemic which has claimed more than six million lives worldwide, devastating the economy and overwhelming healthcare systems globally. The development of new drug molecules and vaccines has played a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7963c6de562984c0e7e0bd38b1abf34
https://doi.org/10.20944/preprints202209.0310.v1
https://doi.org/10.20944/preprints202209.0310.v1
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64837c0876829a0b9019d72507ac5aa8
https://doi.org/10.7554/elife.80813.sa2
https://doi.org/10.7554/elife.80813.sa2
Autor:
Sandeep Chhabra, Simon G. Gooding, Alessia Belgi, Raymond S. Norton, David J. Adams, Samuel D. Robinson, James Burnley, Peter Bartels, Fei Yue Zhao, David Spanswick, Andrea J. Robinson, Khaled A. Elnahriry, Mahsa Sadeghi, Han-Shen Tae, Christopher A. MacRaild, Haifeng Wei
Publikováno v:
Journal of Medicinal Chemistry. 64:3222-3233
Several Conus-derived venom peptides are promising lead compounds for the management of neuropathic pain, with α-conotoxins being of particular interest. Modification of the interlocked disulfide framework of α-conotoxin Vc1.1 has been achieved usi