Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Christopher A DeSouza"'
Autor:
Megan M. Wenner, Laura M. Welti, Caitlin A. Dow, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H732-H738
Endothelin-1 (ET-1) contributes to declines in endothelial function in postmenopausal women. To our knowledge, we show for the first time that aerobic exercise reduces ET-1-mediated vasoconstriction in previously sedentary postmenopausal women. Moreo
Autor:
Hannah K. Fandl, Vinicius P. Garcia, John W. Treuth, Lillian M. Brewster, Jared J. Greiner, Kevin P. Davy, Brian L. Stauffer, Christopher A. Desouza
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H675-H685
In the present study we determined the effect of endothelial microvesicles (EMVs) isolated from obese/hypertensive adults on mediators of cardiomyocyte hypertrophy [cardiac troponin T (cTnT), α-actinin, nuclear factor-kB (NF-kB)] and fibrosis [trans
Autor:
Daniel H. Craighead, Thomas C. Heinbockel, Kaitlin A. Freeberg, Matthew J. Rossman, Rachel A. Jackman, Lindsey R. Jankowski, Makinzie N. Hamilton, Brian P. Ziemba, Julie A. Reisz, Angelo D’Alessandro, L. Madden Brewster, Christopher A. DeSouza, Zhiying You, Michel Chonchol, E. Fiona Bailey, Douglas R. Seals
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background High‐resistance inspiratory muscle strength training (IMST) is a novel, time‐efficient physical training modality. Methods and Results We performed a double‐blind, randomized, sham‐controlled trial to investigate whether 6 weeks of
Externí odkaz:
https://doaj.org/article/1602bf99488a48488f801f7346086204
Autor:
Andrew J. Park, Hannah K. Fandl, Vinicius P. Garcia, Geoff B. Coombs, Noah M. DeSouza, Jared J Greiner, Otto F. Barak, Tanja Mijacika, Zeljko Dujic, Philip N. Ainslie, Christopher A. DeSouza
Publikováno v:
Topics in Spinal Cord Injury Rehabilitation. 29:34-42
Background Spinal cord injury (SCI) is associated with an increased risk and prevalence of cardiopulmonary and cerebrovascular disease-related morbidity and mortality. The factors that initiate, promote, and accelerate vascular diseases and events in
Autor:
Jamie G. Hijmans, Kelly A. Stockelman, Vinicius Garcia, Ma'ayan V. Levy, L. Madden Brewster, Tyler D. Bammert, Jared J. Greiner, Brian L. Stauffer, Elizabeth Connick, Christopher A. DeSouza
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)
Background Circulating microparticles have emerged as biomarkers and effectors of vascular disease. Elevated rates of cardiovascular disease are seen in HIV‐1–seropositive individuals. The aims of this study were to determine: (1) if circulating
Externí odkaz:
https://doaj.org/article/077c7701a02e4575b4ec463ce5c1606e
Autor:
Rachel Stone, David B. MacLeod, Philip N. Ainslie, John D. Akins, Michael M. Tymko, Anthony R Bain, Joshua C. Tremblay, Christopher A. DeSouza
Publikováno v:
The Journal of Physiology. 600:1373-1383
Key points Vascular dysfunction has been demonstrated in lowlanders at high-altitude (>4,000 m), however the extent of impairment and the delineation of contributing mechanisms have remained unclear. Using the gold-standard isolated perfused forearm
Autor:
Brian L. Stauffer, Caitlin A. Dow, Kyle J. Diehl, Tyler D. Bammert, Jared J. Greiner, Christopher A. DeSouza
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 11 (2017)
BackgroundVascular endothelial fibrinolytic function is impaired in adults with prehypertension and hypertension and plays a mechanistic role in the development of atherothrombotic events. The influence of β‐blockers on endothelial fibrinolysis is
Externí odkaz:
https://doaj.org/article/d4ce4bbc4b624331a25edb1b9074703d
Autor:
Christian S DeSouza, Vinicius P Garcia, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
Publikováno v:
Hypertension. 79
Aside from age, hypertension is the most predominant cardiovascular disease risk factor worldwide. In the United States, ~45% of the adult population have blood pressure higher than 130/80 mmHg. Hypertension is associated with increased risk of myoca
Autor:
Hannah K Fandl, Christian S DeSouza, Vinicius P Garcia, Jared J Greiner, Brian L Stauffer, Christopher A Desouza
Publikováno v:
Hypertension. 79
Nebivolol and metoprolol are effective blood pressure medications that also reduce risk of cardiovascular and cerebrovascular events. Endothelial cell-derived microvesicles (EMVs) are small anucleoid, extracellular vesicles released in response to a
Autor:
Vinicius P Garcia, Hannah K Fandl, Noah M DeSouza, Auburn R Berry, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
Publikováno v:
Hypertension. 79
We have previously demonstrated that endothelial cell-derived microvesicles (EMVs) are elevated with hypertension and are associated with endothelial dysfunction. However, it is unknown whether EMVs play a causative role in blood pressure-related end