Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Christopher A Ahern"'
Autor:
Peter R Strege, Luke M Cowan, Constanza Alcaino, Amelia Mazzone, Christopher A Ahern, Lorin S Milescu, Gianrico Farrugia, Arthur Beyder
Publikováno v:
eLife, Vol 12 (2023)
Voltage-gated ion channels (VGICs) orchestrate electrical activities that drive mechanical functions in contractile tissues such as the heart and gut. In turn, contractions change membrane tension and impact ion channels. VGICs are mechanosensitive,
Externí odkaz:
https://doaj.org/article/b8dfecfda4b3488889b0906796a76808
Autor:
Lilia Leisle, Yanyan Xu, Eva Fortea, Sangyun Lee, Jason D Galpin, Malvin Vien, Christopher A Ahern, Alessio Accardi, Simon Bernèche
Publikováno v:
eLife, Vol 9 (2020)
The CLC family comprises H+-coupled exchangers and Cl- channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates through p
Externí odkaz:
https://doaj.org/article/c9ee0e91e4b94b3f972f512b0980c861
Autor:
Erkin Kuru, Jonathan Rittichier, Helena de Puig, Allison Flores, Subhrajit Rout, Isaac Han, Abigail E. Reese, Thomas M. Bartlett, Fabio De Moliner, Sylvie G. Bernier, Jason D. Galpin, Jorge Marchand, William Bedell, Lindsey Robinson-McCarthy, Christopher A. Ahern, Thomas G. Bernhardt, David Z. Rudner, James J. Collins, Marc Vendrell, George M. Church
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Binding-activated optical sensors are powerful tools for imaging, diagnostics, and biomolecular sensing. However, biosensor discovery is slow and requires tedious steps in rational design, screening, and characterization. Here we report on a
Externí odkaz:
https://doaj.org/article/8c008f8b3019484da6521bb74160e592
Autor:
Ammon Thompson, Daniel T Infield, Adam R Smith, G Troy Smith, Christopher A Ahern, Harold H Zakon
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2004892 (2018)
Most weakly electric fish navigate and communicate by sensing electric signals generated by their muscle-derived electric organs. Adults of one lineage (Apteronotidae), which discharge their electric organs in excess of 1 kHz, instead have an electri
Externí odkaz:
https://doaj.org/article/b3f1407423d5432897bc8107e4845514
Autor:
Ximena Steinberg, Marina A Kasimova, Deny Cabezas-Bratesco, Jason D Galpin, Ernesto Ladron-de-Guevara, Federica Villa, Vincenzo Carnevale, Leon Islas, Christopher A Ahern, Sebastian E Brauchi
Publikováno v:
eLife, Vol 6 (2017)
TRPV1 channels support the detection of noxious and nociceptive input. Currently available functional and structural data suggest that TRPV1 channels have two gates within their permeation pathway: one formed by a ′bundle-crossing′ at the intrace
Externí odkaz:
https://doaj.org/article/e4e42bcba24346b89390245eefc87a77
Autor:
Lilia Leisle, Rahul Chadda, John D Lueck, Daniel T Infield, Jason D Galpin, Venkatramanan Krishnamani, Janice L Robertson, Christopher A Ahern
Publikováno v:
eLife, Vol 5 (2016)
A general method is described for the site-specific genetic encoding of cyanine dyes as non-canonical amino acids (Cy-ncAAs) into proteins. The approach relies on an improved technique for nonsense suppression with in vitro misacylated orthogonal tRN
Externí odkaz:
https://doaj.org/article/217eeb09083548d5bba5fc63e7377a1b
Autor:
John D Lueck, Adam L Mackey, Daniel T Infield, Jason D Galpin, Jing Li, Benoît Roux, Christopher A Ahern
Publikováno v:
eLife, Vol 5 (2016)
C-type inactivation of potassium channels fine-tunes the electrical signaling in excitable cells through an internal timing mechanism that is mediated by a hydrogen bond network in the channels' selectively filter. Previously, we used nonsense suppre
Externí odkaz:
https://doaj.org/article/38ecdcda574541cb86ba5c710dddc93b
Publikováno v:
eLife, Vol 2 (2013)
Voltage-gated potassium (Kv) channels enable potassium efflux and membrane repolarization in excitable tissues. Many Kv channels undergo a progressive loss of ion conductance in the presence of a prolonged voltage stimulus, termed slow inactivation,
Externí odkaz:
https://doaj.org/article/3b72f1617db845bc8678de84d4eabe25
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-11 (2020)
Abstract Efforts to identify the causes of autism spectrum disorders have highlighted the importance of both genetics and environment, but the lack of human models for many of these disorders limits researchers’ attempts to understand the mechanism
Externí odkaz:
https://doaj.org/article/16e7d985df8849498291ba22d57afbab
Autor:
John D. Lueck, Jae Seok Yoon, Alfredo Perales-Puchalt, Adam L. Mackey, Daniel T. Infield, Mark A. Behlke, Marshall R. Pope, David B. Weiner, William R. Skach, Paul B. McCray, Christopher A. Ahern
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Premature termination codon suppression therapy could be used to treat a range of genetic disorders. Here the authors present a high-throughput cell-based assay to identify anticodon engineered tRNAs with high suppression activity.
Externí odkaz:
https://doaj.org/article/407180d474f9434ca10313d5ef3ae933