Zobrazeno 1 - 10
of 633
pro vyhledávání: '"Christopher A, Ross"'
Autor:
Nam-Shik Kim, Zhexing Wen, Jing Liu, Ying Zhou, Ziyuan Guo, Chongchong Xu, Yu-Ting Lin, Ki-Jun Yoon, Junhyun Park, Michelle Cho, Minji Kim, Xinyuan Wang, Huimei Yu, Srilatha Salamuru, Kimberly M. Christian, Kuei-sen Hsu, Menghang Xia, Weidong Li, Christopher A. Ross, Russell L. Margolis, Xin-Yun Lu, Hongjun Song, Guo-li Ming
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.
Externí odkaz:
https://doaj.org/article/a1c93081300b4869a2a2b16a518720f6
Autor:
Houda G. Khaled, Hongxuan Feng, Xin Hu, Xin Sun, Wang Zheng, Pan P. Li, Dobrila D. Rudnicki, Wenjuan Ye, Yu-Chi Chen, Noel Southall, Juan Marugan, Christopher A. Ross, Marc Ferrer, Mark J. Henderson, Russell L. Margolis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of huntingtin (HTT). While there are currently no disease-modifying treatments for HD, recent efforts have focused on the development of n
Externí odkaz:
https://doaj.org/article/e1dbdd8b7e1f49f1934d1a2643d9a73c
Publikováno v:
HTS Teologiese Studies/Theological Studies, Vol 78, Iss 4, Pp e1-e10 (2022)
Working within the sensing, intuition, feeling, thinking (SIFT) approach to biblical hermeneutics, the present study focuses attention on the distinctive voices of introverted intuition and extraverted intuition, by analysing the way in which two sma
Externí odkaz:
https://doaj.org/article/181f0f6a39bf43b3b28e4b2ffa3472bc
Autor:
Jinru Zhang, Kai Li, Xiaobo Wang, Amber M. Smith, Bo Ning, Zhaohui Liu, Chunfeng Liu, Christopher A. Ross, Wanli W. Smith
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Mutations in leucine-rich repeat kinase 2 gene (LRRK2) are the most frequent genetic factors contributing to Parkinson's disease (PD). G2385R-LRRK2 increases the risk for PD susceptibility in the Chinese population. However, the pathological role of
Externí odkaz:
https://doaj.org/article/eb7cb181d6e848339e64e01118dd5ea4
Autor:
Chelsy R. Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R. Hayden, Christopher A. Ross
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 118-129 (2019)
Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein with a polyglutamine expansion. There is preferential loss of medium spiny neurons within the
Externí odkaz:
https://doaj.org/article/6c7c6a1004604c76b60f2b97bd104cc6
Autor:
Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández, Rogan A. Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A. Ross, Udai B. Pandey, José J. Lucas, Frédéric Saudou, Maria Pennuto, Manuela Basso
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108980- (2021)
Summary: The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disru
Externí odkaz:
https://doaj.org/article/4ec24cea628a418d9972d9f2b7afcdb5
Publikováno v:
HTS Teologiese Studies/Theological Studies, Vol 76, Iss 1, Pp e1-e10 (2020)
Psalm 73 is a challenging Psalm in which the Psalmist draws on rich imagery to juxtapose doctrine and experience and to juxtapose the goodness of God with divine retribution. Drawing on data provided by 15 theological educators within the Anglican Di
Externí odkaz:
https://doaj.org/article/1050fb21619e4f7ab6fc2ccbd7a24409
Autor:
Xiaobo Wang, Tengteng Wu, Jinru Zhang, Gongbo Guo, XiaoFei He, Zhong Pei, Zhaohui Liu, Chun-feng Liu, Christopher A. Ross, Wanli W. Smith
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Mutations in transmembrane protein 230 (TMEM230) gene are suggested to be associated with the autosomal dominant Parkinson’s disease (PD) with typical movement disorders and Lewy body pathology. However, the normal functions and the pathological ro
Externí odkaz:
https://doaj.org/article/aadc308d88524e669e9e89ca13629bf9
Autor:
Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu, Dennis J. Thiele
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevat
Externí odkaz:
https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861
Autor:
Jing Jin, Nicolas Arbez, James J. Sahn, Yan Lu, Kathryn T. Linkens, Timothy R. Hodges, Anthony Tang, Robyn Wiseman, Stephen F. Martin, Christopher A. Ross
Publikováno v:
ACS Chemical Neuroscience. 13:2852-2862
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d4d59d455e06d6fccd131af702a97c
https://doi.org/10.1021/acschemneuro.2c00274
https://doi.org/10.1021/acschemneuro.2c00274