Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Christopher A, Lear"'
Autor:
Shoichi Magawa, Christopher A. Lear, Michael J. Beacom, Victoria J. King, Michi Kasai, Robert Galinsky, Tomoaki Ikeda, Alistair J. Gunn, Laura Bennet
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Perinatal infection/inflammation can trigger preterm birth and contribute to neurodevelopmental disability. There are currently no sensitive, specific methods to identify perinatal infection. We investigated the utility of time, frequency an
Externí odkaz:
https://doaj.org/article/251666f9beb24fe8a8b6176016afd97f
Publikováno v:
Bioengineering, Vol 10, Iss 7, p 775 (2023)
Our objective is to develop a model for the prediction of minimum fetal blood pressure (FBP) during fetal heart rate (FHR) decelerations. Experimental data from umbilical occlusions in near-term fetal sheep (2698 occlusions from 57 near-term lambs) w
Externí odkaz:
https://doaj.org/article/247563fb657a4c65a64c411d469bc4cf
Autor:
Simerdeep K. Dhillon, Eleanor R. Gunn, Benjamin A. Lear, Victoria J. King, Christopher A. Lear, Guido Wassink, Joanne O. Davidson, Laura Bennet, Alistair J. Gunn
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Perinatal hypoxia-ischemia (HI) is still a significant contributor to mortality and adverse neurodevelopmental outcomes in term and preterm infants. HI brain injury evolves over hours to days, and involves complex interactions between the endogenous
Externí odkaz:
https://doaj.org/article/f50669a6ad1f468395ebf94787cdf834
Autor:
Clémence Disdier, Fares Awa, Xiaodi Chen, Simerdeep K. Dhillon, Robert Galinsky, Joanne O. Davidson, Christopher A. Lear, Laura Bennet, Alistair J. Gunn, Barbara S. Stonestreet
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Exposure to inflammation during pregnancy can predispose to brain injury in premature infants. In the present study, we investigated the effects of prolonged exposure to inflammation on the cerebrovasculature of preterm fetal shee
Externí odkaz:
https://doaj.org/article/a131e8a1acbb4ce2b782ab0544943b31
Autor:
Robert Galinsky, Simerdeep K. Dhillon, Justin M. Dean, Joanne O. Davidson, Christopher A. Lear, Guido Wassink, Fraser Nott, Sharmony B. Kelly, Mhoyra Fraser, Caroline Yuill, Laura Bennet, Alistair Jan Gunn
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Increased circulating levels of tumor necrosis factor (TNF) are associated with greater risk of impaired neurodevelopment after preterm birth. In this study, we tested the hypothesis that systemic TNF inhibition, using the soluble
Externí odkaz:
https://doaj.org/article/bbe15fb44fbd4724a926bed34f2b3e76
Autor:
Austin Ugwumadu, Peter Stone, Alexane Tournier, Christopher A. Lear, Alistair J. Gunn, Jenny A. Westgate, Laura Bennet
Publikováno v:
American Journal of Obstetrics and Gynecology. 228:S1117-S1128
Uterine contractions during labor and engagement of the fetus in the birth canal can compress the fetal head. Its impact on the fetus is unclear and still controversial. In this integrative physiological review, we highlight evidence that deceleratio
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 137, Iss , Pp 111398- (2021)
Externí odkaz:
https://doaj.org/article/35c00a1dcecf409589cb0e4e9bdcbed5
Autor:
Christopher A. Lear, Michael J. Beacom, Simerdeep K. Dhillon, Benjamin A. Lear, Olivia J. Mills, Mark I. Gunning, Jenny A. Westgate, Laura Bennet, Alistair J. Gunn
Publikováno v:
The Journal of Physiology. 601:2017-2041
Autor:
Simerdeep K Dhillon, Eleanor R Gunn, Mette V Pedersen, Christopher A Lear, Guido Wassink, Joanne O Davidson, Alistair J Gunn, Laura Bennet
Publikováno v:
Dhillon, S K, Gunn, E, Pedersen, M V, Learn, C, Wassink, G, Davidson, J O, Gunn, A J & Bennet, L 2023, ' Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons ', Journal of Cerebral Blood Flow and Metabolism .
Aarhus University
Aarhus University
Exposure to hypoxic-ischaemia (HI) is consistently followed by a delayed fall in cerebral perfusion. In preterm fetal sheep this is associated with impaired cerebral oxygenation, consistent with mismatch between perfusion and metabolism. In the prese
Publikováno v:
Bioengineering; Volume 10; Issue 7; Pages: 775
Our objective is to develop a model for the prediction of minimum fetal blood pressure (FBP) during fetal heart rate (FHR) decelerations. Experimental data from umbilical occlusions in near-term fetal sheep (2698 occlusions from 57 near-term lambs) w