Výsledky vyhledávání - "Christopher A, Flask"

CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3

Autor: Abhrajit Ganguly, Bernadette O. Erokwu, Catherine A. Mayer, Richard J. Martin, Peter M. MacFarlane, Vince C Hascall, Christina M. Pabelick, Ron J Midura, Aubrey Mayer, Y. S. Prakash, Valbona Cali, Christopher A Flask

Publikováno v: Pediatric Research. 92:685-693

Background Continuous positive airway pressure (CPAP) is a primary mode of respiratory support for preterm infants. Animal studies have shown long-term detrimental effects on lung/airway development, particularly airway (AW) hyper-reactivity, as an u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d05ab3e3dfd5c74e945df1ce04821c35
https://doi.org/10.1038/s41390-021-01695-0

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Targeted Radiosensitizers for MR-Guided Radiation Therapy of Prostate Cancer

Autor: Xinning Wang, Christopher A Flask, Sarah Springer, Hao Li, Dong Luo, Gopalakrishnan Ramamurthy, Bernadette O. Erokwu, Andrew Johnson, James P. Basilion, Clemens Burda, Jason Lou, Thomas J. Meade

Publikováno v: Nano Lett

Adjuvant radiotherapy is frequently prescribed to treat cancer. To minimize radiation-related damage to healthy tissue, it requires high precision in tumor localization and radiation dose delivery. This can be achieved by MR guidance and targeted amp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525017aa6579b907c6ca0b785c0c8961
https://doi.org/10.1021/acs.nanolett.0c02487

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Lumacaftor/ivacaftor therapy is associated with reduced hepatic steatosis in cystic fibrosis patients

Autor: Thomas J Sferra, Christopher A Flask, Rose Gubitosi-Klug, Kimberly McBennett, MaryAnn O'Riordan, Shannon B. Donnola, Katherine Kutney, Beth Kaminski

Publikováno v: World Journal of Hepatology

Background Hepatic steatosis is a common form of cystic fibrosis associated liver disease (CFLD) seen in an estimated 15%-60% of patients with cystic fibrosis (CF). The pathophysiology and health implications of hepatic steatosis in cystic fibrosis r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca2a77404f0bb0bda4c2ec20379c0f4
https://doi.org/10.4254/wjh.v11.i12.761

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Stromal derived factor-1 plasmid as a novel injection for treatment of stress urinary incontinence in a rat model

Autor: Adonis Hijaz, Amr Mahran, Marc S. Penn, Juliana Woda, Ilaha Isali, Michael Kavran, Christopher A Flask, Ahmad O. Khalifa

Publikováno v: International Urogynecology Journal. 31:107-115

SDF-1 chemokine enhances tissue regeneration through stem cell chemotaxis, neovascularization and neuronal regeneration. We hypothesized that non-viral delivery of human plasmids that express SDF-1 (pSDF-1) may represent a novel regenerative therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e33d1b5866d9b5a94b975bfa6d2296f
https://doi.org/10.1007/s00192-019-03867-3

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A DNA-Based MRI Contrast Agent for Quantitative pH Measurement

Autor: Alissa D. Buskermolen, Kristine Y. Ma, Hyewon Seo, Erin E. Tuttle, Christopher A Flask, Heather A. Clark, Isen Andrew C. Calderon

Publikováno v: ACS Sens

Extracellular pH is important in clinical measurements due to its correlation to cell metabolism and disease progression. In MRI, T(1)/T(2) ratiometric analysis and other methods have been previously applied to quantify pH using conventional pulse se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8dc2c7da9c91862c6571e4d4c30712
https://europepmc.org/articles/PMC9489053/

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CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3

Autor: Catherine A, Mayer, Abhrajit, Ganguly, Aubrey, Mayer, Christina M, Pabelick, Y S, Prakash, Vince C, Hascall, Ron J, Midura, Valbona, Cali, Christopher A, Flask, Bernadette O, Erokwu, Richard J, Martin, Peter M, MacFarlane

Publikováno v: Pediatric research. 92(3)

Continuous positive airway pressure (CPAP) is a primary mode of respiratory support for preterm infants. Animal studies have shown long-term detrimental effects on lung/airway development, particularly airway (AW) hyper-reactivity, as an unfortunate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::574b853e6f49630980658961e0886fc4
https://pubmed.ncbi.nlm.nih.gov/34750521

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Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD

Autor: Christopher A Flask, Ciaran E. Fealy, Christopher L. Axelrod, Adithya Hari, Jacob M. Haus, John P. Kirwan, Arthur J. McCullough

Publikováno v: Medicine and Science in Sports and Exercise, 52(7), 1449-1455. LIPPINCOTT WILLIAMS & WILKINS
Med Sci Sports Exerc

Purpose We aimed to determine the immediacy of exercise intervention on liver-specific metabolic processes in nonalcoholic fatty liver disease. Methods We undertook a short-term (7-d) exercise training study (60 min.d(-1) treadmill walking at 80%-85%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71df1e648b246517d8544248e9071bd
https://cris.maastrichtuniversity.nl/en/publications/88815c5d-2a25-4f1d-8376-1f60b2032dad

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β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro

Autor: Melissa L. Erickson, William T. King, Christopher A Flask, Christopher L. Axelrod, Jacob T. Mey, John P. Kirwan, Arthur J. McCullough

Publikováno v: Am J Physiol Endocrinol Metab

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation and impaired insulin sensitivity. Reduced hepatic ketogenesis may promote these pathologies, but data are inconclusive in humans and the link between NAFLD and redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c0329586e4d29cc59a7f15d12d0437
https://europepmc.org/articles/PMC7468782/

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Multi-parametric MRI of kidney disease progression for autosomal recessive polycystic kidney disease: mouse model and initial patient results

Autor: Ashlee Parsons, Yong Chen, Uyen Tran, Susan Farr, Oliver Wessely, Katherine MacRae Dell, Dan Ma, Michael Markley, Yifan Zhang, Christopher A Flask, Suraj D. Serai, Christian E. Anderson, Bernadette O. Erokwu, Erum A. Hartung, Christina J MacAskill

Publikováno v: Pediatric research

Autosomal recessive polycystic kidney disease (ARPKD) is a rare but potentially lethal genetic disorder typically characterized by diffuse renal microcysts. Clinical trials for patients with ARPKD are not currently possible due to the absence of sens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109efda1a78f6d68836b487e4a9c0741
https://pubmed.ncbi.nlm.nih.gov/32283547

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