Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Christopher A, Cottrell"'
Autor:
Christopher A. Cottrell, Payal P. Pratap, Kimberly M. Cirelli, Diane G. Carnathan, Chiamaka A. Enemuo, Aleksandar Antanasijevic, Gabriel Ozorowski, Leigh M. Sewall, Hongmei Gao, Joel D. Allen, Bartek Nogal, Murillo Silva, Jinal Bhiman, Matthias Pauthner, Darrell J. Irvine, David Montefiori, Max Crispin, Dennis R. Burton, Guido Silvestri, Shane Crotty, Andrew B. Ward
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the developmen
Externí odkaz:
https://doaj.org/article/bdb802dbabe14d2b9e05554af9fa7556
Autor:
Allan C. deCamp, Martin M. Corcoran, William J. Fulp, Jordan R. Willis, Christopher A. Cottrell, Daniel L. V. Bader, Oleksandr Kalyuzhniy, David J. Leggat, Kristen W. Cohen, Ollivier Hyrien, Sergey Menis, Greg Finak, Lamar Ballweber-Fleming, Abhinaya Srikanth, Jason R. Plyler, Farhad Rahaman, Angela Lombardo, Vincent Philiponis, Rachael E. Whaley, Aaron Seese, Joshua Brand, Alexis M. Ruppel, Wesley Hoyland, Celia R. Mahoney, Alberto Cagigi, Alison Taylor, David M. Brown, David R. Ambrozak, Troy Sincomb, Tina-Marie Mullen, Janine Maenza, Orpheus Kolokythas, Nadia Khati, Jeffrey Bethony, Mario Roederer, David Diemert, Richard A. Koup, Dagna S. Laufer, Juliana M. McElrath, Adrian B. McDermott, Gunilla B. Karlsson Hedestam, William R. Schief
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Vaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for development of precision vaccines against major human pathogens. In a clinical trial of the eOD-GT8 60mer germline-targ
Externí odkaz:
https://doaj.org/article/2e580eabca0b4c0f8e97acb243086a89
Autor:
Kristen A. Rodrigues, Christopher A. Cottrell, Jon M. Steichen, Bettina Groschel, Wuhbet Abraham, Heikyung Suh, Yash Agarwal, Kaiyuan Ni, Jason Y. H. Chang, Parisa Yousefpour, Mariane B. Melo, William R. Schief, Darrell J. Irvine
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract In the ongoing effort to develop a vaccine against HIV, vaccine approaches that promote strong germinal center (GC) responses may be critical to enable the selection and affinity maturation of rare B cell clones capable of evolving to produc
Externí odkaz:
https://doaj.org/article/41280b26b64f4887a8b93d75737a93e1
Autor:
Flavio Matassoli, Alberto Cagigi, Chen-Hsiang Shen, Amy R. Henry, Timothy S. Johnston, Chaim A. Schramm, Christopher A. Cottrell, Oleksandr Kalyuzhniy, Abby Spangler, Leigh Eller, Merlin Robb, Michael Eller, Prossy Naluyima, Peter D. Kwong, Daniel C. Douek, William R. Schief, Sarah F. Andrews, Adrian B. McDermott
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113450- (2023)
Summary: HIV gp120 engineered outer domain germline-targeting version 8 (eOD-GT8) was designed specifically to engage naive B cell precursors of VRC01-class antibodies. However, the frequency and affinity of naive B cell precursors able to recognize
Externí odkaz:
https://doaj.org/article/eb4e28b80f1b4f7e8299b3bde7fa669f
Autor:
Vaneet K. Sharma, Sergey Menis, Evan T. Brower, Eddy Sayeed, Jim Ackland, Angela Lombardo, Christopher A. Cottrell, Jonathan L. Torres, Thomas Hassell, Andrew B. Ward, Vadim Tsvetnitsky, William R. Schief
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 742 (2024)
We describe the current Good Manufacturing Practice (cGMP) production and subsequent characterization of eOD-GT8 60mer, a glycosylated self-assembling nanoparticle HIV-1 vaccine candidate and germline targeting priming immunogen. Production was carri
Externí odkaz:
https://doaj.org/article/a5c660dbcce146b78053fb5ed221bb13
Autor:
Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D. Doyle, Christopher A. Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, David Nemazee, Andrew B. Ward, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
An effective HIV vaccine likely requires the elicitation of neutralizing antibodies (NAbs) against multiple HIV-1 clades. The recently developed cleavage-independent native flexibly linked (NFL) envelope (Env) trimers exhibit well-ordered conformatio
Externí odkaz:
https://doaj.org/article/426af3d593f04edcb1ecad43361ff2ec
Autor:
Jonathan Hurtado, Claudia Flynn, Jeong Hyun Lee, Eugenia C. Salcedo, Christopher A. Cottrell, Patrick D. Skog, Dennis R. Burton, David Nemazee, William R. Schief, Elise Landais, Devin Sok, Bryan Briney
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2023)
The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development. Traditional mAb discovery is a costly and labo
Externí odkaz:
https://doaj.org/article/872e188662cf45d480b2e529faf46daf
Autor:
Iván del Moral-Sánchez, Rebecca A. Russell, Edith E. Schermer, Christopher A. Cottrell, Joel D. Allen, Alba Torrents de la Peña, Celia C. LaBranche, Sanjeev Kumar, Max Crispin, Andrew B. Ward, David C. Montefiori, Quentin J. Sattentau, Kwinten Sliepen, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract Soluble HIV-1 envelope glycoprotein (Env) immunogens are a prime constituent of candidate vaccines designed to induce broadly neutralizing antibodies. Several lines of evidence suggest that enhancing Env immunogen thermostability can improve
Externí odkaz:
https://doaj.org/article/28104a39e7cf4428aa7d7f68001f96c6
Autor:
Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (p
Externí odkaz:
https://doaj.org/article/04ab87746dbe4d4ea81ab039e453c3ac
Autor:
Christopher A. Cottrell, Kartik Manne, Rui Kong, Shuishu Wang, Tongqing Zhou, Gwo-Yu Chuang, Robert J. Edwards, Rory Henderson, Katarzyna Janowska, Megan Kopp, Bob C. Lin, Mark K. Louder, Adam S. Olia, Reda Rawi, Chen-Hsiang Shen, Justin D. Taft, Jonathan L. Torres, Nelson R. Wu, Baoshan Zhang, Nicole A. Doria-Rose, Myron S. Cohen, Barton F. Haynes, Lawrence Shapiro, Andrew B. Ward, Priyamvada Acharya, John R. Mascola, Peter D. Kwong
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109922- (2021)
Summary: Recognition of N-linked glycan at residue N276 (glycan276) at the periphery of the CD4-binding site (CD4bs) on the HIV-envelope trimer is a formidable challenge for many CD4bs-directed antibodies. To understand how this glycan can be recogni
Externí odkaz:
https://doaj.org/article/0dffdf01c46c4651a77c53c885d4f689