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pro vyhledávání: '"Christopher Blackburn"'
Autor:
Christopher Blackburn
Publikováno v:
Przegląd Historyczno-Wojskowy. 22:87-112
This work explores the role of the Red Army in the spread of typhus on Polish lands during the Polish-Bolshevik War, 1919–1920. As a result of the Bolshevik style of war, one of the results of the Soviet advance into Poland was the anti-typhus effo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::364c8a0484abdd85a7485819a9fb38eb
https://doi.org/10.32089/wbh.phw.2021.2(276).0003
https://doi.org/10.32089/wbh.phw.2021.2(276).0003
Akademický článek
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Autor:
Cynthia Barrett, Alexandra E. Gould, Janice Chin, Mable Brunson, John Ringeling, Christopher Tsu, R. Scott Rowland, Krista Wager, Kara Hoar, Juan Gutierrez, He Xu, Dylan England, Kris Garcia, Christopher Blackburn, Kenneth Gigstad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5450-5454
Acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide are potent sub-type selective HDAC6 inhibitors. Constrained heterocyclic analogs based on 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine show further enhanced HDAC6 selectivity and inhibitory activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76984e37b68c0abc013438b7f50f96ec
https://doi.org/10.1016/j.bmcl.2014.10.022
https://doi.org/10.1016/j.bmcl.2014.10.022
Autor:
Gang Li, Christopher Tsu, Lawrence Dick, Christopher Blackburn, Paul Hales, Matthew Bogyo, Hao Li
Publikováno v:
Journal of the American Chemical Society
We have identified short N,C-capped peptides that selectively inhibit the proteasome of the malaria-causing pathogen Plasmodium falciparum. These compounds are highly potent in culture with no toxicity in host cells. One cyclic biphenyl ether compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b2ea6e5d4d908d307f53bc3084c002
http://europepmc.org/articles/PMC4183598
http://europepmc.org/articles/PMC4183598
Autor:
Julien Vaubourgeix, Lawrence Dick, Thulasi Warrier, Tamutenda Chidawanyika, Carl Nathan, Christopher Tsu, Kenneth M. Gigstad, Gang Lin, Christopher Blackburn, Michael D. Sintchak
Publikováno v:
Journal of the American Chemical Society. 135:9968-9971
We identified N,C-capped dipeptides that are selective for the Mycobacterium tuberculosis proteasome over human constitutive and immunoproteasomes. Differences in S3 and S1 binding pockets appeared to account for species-selectivity. The inhibitors a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4989e993de75480bd8137a2de3d079dd
https://doi.org/10.1021/ja400021x
https://doi.org/10.1021/ja400021x
The addition of Li + to ferrocene bis-tertiary amide derivatives in acetonitrile results in a shift of the ferrocene oxidation wave to more positive potentials and the appearance of a new redox couple associated with a Li + complex.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bec0ee7bc69e3e99c6606080314ca5
https://doi.org/10.1016/0022-328x(88)80384-x
https://doi.org/10.1016/0022-328x(88)80384-x
The new ferrocenyl ionophore (6) selectively complexes, electrochemically recognises, and responds to the potassium guest cation in the presence of equimolar amounts of sodium and magnesium ions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cdcc3e07b4c3cdede698b7ac110984
https://doi.org/10.1039/c39890001831
https://doi.org/10.1039/c39890001831
The syntheses of new redox-active crown ethers 8a, 8b, 9a, and 9b containing cis- and trans-conjugated olefinic linkages between the ferrocene redox center and respectively benzo-15-crown-5 and N-phenylaza-15-crown-5 are described. The sodium cation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb704887742a818ceb78c15e278b634f
https://doi.org/10.1021/ic00328a006
https://doi.org/10.1021/ic00328a006
Autor:
Christopher Blackburn
Publikováno v:
ACS Combinatorial Science. 14:150-154
Reductive aminations and further transformations of an azo dye and fluorous tagged aldehyde are described. The intensely colored 2,4-dialkoxybenzyl protected amines undergo Fmoc-based peptide coupling, Suzuki reactions, and sulfonamide formation with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326971eb797e9bfbf337bf7b7d33778a
https://doi.org/10.1021/co2002153
https://doi.org/10.1021/co2002153
Autor:
Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon
Publikováno v:
Journal of Medicinal Chemistry. 54:1836-1846
Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48918d40f47903a78da39dee5fa5f8e
https://doi.org/10.1021/jm101479y
https://doi.org/10.1021/jm101479y