Výsledky vyhledávání - "Christopher, Wolfgang"

Akademický článek

Consensus, debate, and prospective on pancreatic cancer treatments

Autor: Junke Wang, Jie Yang, Amol Narang, Jin He, Christopher Wolfgang, Keyu Li, Lei Zheng

Publikováno v: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-59 (2024)

Abstract Pancreatic cancer remains one of the most aggressive solid tumors. As a systemic disease, despite the improvement of multi-modality treatment strategies, the prognosis of pancreatic cancer was not improved dramatically. For resectable or bor

Externí odkaz: https://doaj.org/article/cfa2dae443434f43a2a18f817f372037

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Akademický článek

A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract A neoadjuvant immunotherapy platform clinical trial allows for rapid evaluation of treatment-related changes in tumors and identifying targets to optimize treatment responses. We enrolled patients with resectable pancreatic adenocarcinoma in

Externí odkaz: https://doaj.org/article/29ddb7f12a474eabab8b5226fc44a8fd

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Akademický článek

High local failure rates despite high margin‐negative resection rates in a cohort of borderline resectable and locally advanced pancreatic cancer patients treated with stereotactic body radiation therapy following multi‐agent chemotherapy

Autor: Colin Hill, Shuchi Sehgal, Wei Fu, Chen Hu, Abhinav Reddy, Elizabeth Thompson, Amy Hacker‐Prietz, Dung Le, Ana De Jesus‐Acosta, Valerie Lee, Lei Zheng, Daniel A. Laheru, William Burns, Matthew Weiss, Christopher Wolfgang, Jin He, Joseph M. Herman, Jeffrey Meyer, Amol Narang

Publikováno v: Cancer Medicine, Vol 11, Iss 7, Pp 1659-1668 (2022)

Abstract Background Stereotactic body radiation therapy (SBRT) for patients with borderline resectable and locally advanced pancreatic adenocarcinoma (BRPC/LAPC) remains controversial. Herein, we report on surgical, pathologic, and survival outcomes

Externí odkaz: https://doaj.org/article/6a4eefa2f3d84dbfa8e1d6f3552aab2f

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Akademický článek

Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

Publikováno v: Clinical Epigenetics, Vol 11, Iss 1, Pp 1-10 (2019)

Abstract Background Despite improvements in cancer management, most pancreatic cancers are still diagnosed at an advanced stage. We have recently identified promoter DNA methylation of the genes ADAMTS1 and BNC1 as potential blood biomarkers of pancr

Externí odkaz: https://doaj.org/article/5ee67cadac9942d2bebf4c36ab2fd50c

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Using machine learning to preoperatively stratify prognosis among patients with gallbladder cancer: a multi-institutional analysis

Autor: Garrett Cotter, Eliza W. Beal, George A. Poultsides, Kamran Idrees, Ryan C. Fields, Sharon M. Weber, Charles R. Scoggins, Perry Shen, Christopher Wolfgang, Shishir K. Maithel, Timothy M. Pawlik

Publikováno v: HPB. 24:1980-1988

Gallbladder cancer (GBC) is an aggressive malignancy associated with a high risk of recurrence and mortality. We used a machine-based learning approach to stratify patients into distinct prognostic groups using preperative variables.Patients undergoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc2a185c4ea10589143212828d4cdb8
https://doi.org/10.1016/j.hpb.2022.06.008

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Data from Having Pancreatic Cancer with Tumoral Loss of ATM and Normal TP53 Protein Expression Is Associated with a Poorer Prognosis

Autor: Michael Goggins, Ralph H. Hruban, Volkan N. Adsay, Joseph Herman, Christopher Wolfgang, Alison Klein, Erica Childs, Michael Borges, Spencer Knight, Burcu Saka, Haeryoung Kim

Purpose: To determine how often loss of ataxia-telangiectasia–mutated (ATM) protein expression occurs in primary pancreatic ductal adenocarcinomas and to determine its prognostic significance.Experimental Design: The expression of ATM and TP53 was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5346c329f5358ea17bfcdb491e7b8519
https://doi.org/10.1158/1078-0432.c.6522471.v1

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Supplementary figures s1-s15 from Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas

Autor: Michael Goggins, Ralph H. Hruban, Anne Marie Lennon, Christopher Wolfgang, Marcia I. Canto, Matthew Weiss, Meredith Pittman, Jun Yu, Masaya Suenaga, Marco Dal Molin, Tatsuo Hata

Figure S1: Coefficient of variation telomerase assay. Figure S2: Telomerase assay controls Figure S3; Serial dilution, limit of detection telomerase assay, Figure S4; Protein extraction and assay performance; Figure S5; Lack of telomerase activity in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625082f2de55b14698b21918eb312bef
https://doi.org/10.1158/1078-0432.22466661

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