Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christopher, Pfleger"'
Autor:
Pablo Perez-Garcia, Jennifer Chow, Elisa Costanzi, Marno Gurschke, Jonas Dittrich, Robert F. Dierkes, Rebecka Molitor, Violetta Applegate, Golo Feuerriegel, Prince Tete, Dominik Danso, Stephan Thies, Julia Schumacher, Christopher Pfleger, Karl-Erich Jaeger, Holger Gohlke, Sander H. J. Smits, Ruth A. Schmitz, Wolfgang R. Streit
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Polyethylene terephthalate (PET) is a commodity polymer known to globally contaminate marine and terrestrial environments. Today, around 80 bacterial and fungal PET-active enzymes (PETases) are known, originating from four bacterial and two
Externí odkaz:
https://doaj.org/article/3f5a06e0963f4ed9ae54ed7aaef0b43a
Autor:
Ramona Marasco, Marco Fusi, Cristina Coscolín, Alan Barozzi, David Almendral, Rafael Bargiela, Christina Gohlke neé Nutschel, Christopher Pfleger, Jonas Dittrich, Holger Gohlke, Ruth Matesanz, Sergio Sanchez-Carrillo, Francesca Mapelli, Tatyana N. Chernikova, Peter N. Golyshin, Manuel Ferrer, Daniele Daffonchio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Temperature shapes the adaptation and composition of microbiomes, but whether their enzymes drive the thermal response remains unknown. Using an analysis of seven enzyme classes from worldwide marine microbiome data, this study shows that enzyme ther
Externí odkaz:
https://doaj.org/article/b1e2f1fc353d41fcb912f79da11661b0
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Inositols (cyclohexanehexols) comprise nine isomeric cyclic sugar alcohols, several of which occur in all domains of life with various functions. Many bacteria can utilize inositols as carbon and energy sources via a specific pathway involvi
Externí odkaz:
https://doaj.org/article/d9a3acc54cdf4ef585f10b05418c41f5
Autor:
Sezin Yüksel, Michele Bonus, Tina Schwabe, Christopher Pfleger, Thomas Zimmer, Uta Enke, Inga Saß, Holger Gohlke, Klaus Benndorf, Jana Kusch
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by membrane hyperpolarization. The binding of cAMP to th
Externí odkaz:
https://doaj.org/article/9fd4821d4e2641c9a8abc668af73cd8c
Autor:
Pablo Perez-Garcia, Jennifer Chow, Elisa Costanzi, Marno F. Gurschke, Jonas Dittrich, Robert F. Dierkes, Violetta Applegate, Golo Feuerriegel, Prince Tete, Dominik Danso, Julia Schumacher, Christopher Pfleger, Holger Gohlke, Sander H. J. Smits, Ruth A. Schmitz, Wolfgang R. Streit
Publikováno v:
bioRxiv
Polyethylene terephthalate (PET) is a commodity polymer known to globally contaminate marine and terrestrial environments. Today, around 40 bacterial and fungal PET-active enzymes (PETases) are known, originating from four bacterial and two fungal ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affffd34be3b2fc84b3c742e7138edf1
https://zenodo.org/record/7528688
https://zenodo.org/record/7528688
Autor:
Armin Buschauer, Christopher Pfleger, Timothy Clark, Jonas Kaindl, Holger Gohlke, Ralf C. Kling, Passainte Ibrahim, David Wifling
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Histamine H4 receptor (H4R) orthologues are G‐protein‐coupled receptors (GPCRs) that exhibit species‐dependent basal activity. In contrast to the basally inactive mouse H4R (mH4R), human H4R (hH4R) shows a high degree of basal activity. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d3d75f5ae14aade1d4720d7f1bc3dc
http://europepmc.org/articles/PMC7687114
http://europepmc.org/articles/PMC7687114
Autor:
Birgit Budde, Mila Beyer, Jörg Schipper, Birgit Lorenz, Boris Görg, Ulrich Zechner, Hans-Jörg Wittsack, Diran Herebian, Christopher Pfleger, Hanno J. Bolz, Janine Altmüller, Jörg Schaper, Natalia Qvartskhava, Markus N. Preising, Dieter Häussinger, Alfons Schnitzler, Holger Gohlke, Mohammad R. Toliat, Peter Nürnberg, Christoph Friedburg, Michele Bonus, Helge J. Zöllner, Dirk Klee
Publikováno v:
The FASEB Journal. 33:11507-11527
We previously reported that inactivation of the transmembrane taurine transporter (TauT or solute carrier 6a6) causes early retinal degeneration in mice. Compatible with taurine’s indispensability ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c6dc5010efc24144413470e7e7116c
https://doi.org/10.1096/fj.201900914rr
https://doi.org/10.1096/fj.201900914rr
Autor:
Klaus Benndorf, Christopher Pfleger, Jana Kusch, Christian Sattler, Mahesh Kondapuram, Tina Schwabe, Holger Gohlke
Opening of hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels is controlled by membrane hyperpolarization and binding of cyclic nucleotides to the tetrameric cyclic nucleotide-binding domain (CNBD), attached to the C-linker disk (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a62ad5554f46cbbe12f2bfda448c03
https://doi.org/10.1101/2020.06.13.150086
https://doi.org/10.1101/2020.06.13.150086
Autor:
Christopher Pfleger, Holger Gohlke, Alexander Minges, Markus Boehm, Christopher L. McClendon, Rubben Torella
Publikováno v:
Journal of Chemical Theory and Computation. 13:6343-6357
Allostery describes the functional coupling between sites in biomolecules. Recently, the role of changes in protein dynamics for allosteric communication has been highlighted. A quantitative and predictive description of allostery is fundamental for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c6ecfe48ce0a29eb109b74d09772a4
https://doi.org/10.1021/acs.jctc.7b00529
https://doi.org/10.1021/acs.jctc.7b00529
Publikováno v:
Journal of chemical information and modeling 59(1), 509–521 (2019). doi:10.1021/acs.jcim.8b00582
We present DrugScore2018, a new version of the knowledge-based scoring functionDrugScore, which builds upon the same formalism used to derive DrugScore, but exploits atraining data set of nearly 40,000 X-ray complex structures, a highly diverse and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69400a0e61a3f5eee3384b19bf4cae82
https://juser.fz-juelich.de/record/858302
https://juser.fz-juelich.de/record/858302