Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Christopher, Liddle"'
Autor:
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F. M. Pinto, Dylan C. Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T. Yu, Tony Hunter, Dannielle D. Engle, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetyla
Externí odkaz:
https://doaj.org/article/7cb7b07e6adf42b0aac1cff0935b9ca2
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Jawaher Alharthi, Ali Bayoumi, Khaled Thabet, Ziyan Pan, Brian S. Gloss, Olivier Latchoumanin, Mischa Lundberg, Natalie A. Twine, Duncan McLeod, Shafi Alenizi, Leon A. Adams, Martin Weltman, Thomas Berg, Christopher Liddle, Jacob George, Mohammed Eslam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Hyperactivation of the toll-like receptors (TLRs) have been implicated as risk factors for more severe forms of disease in COVID-19 and metabolic (dysfunction) associated fatty liver disease (MAFLD). Here the authors report that MBOAT7 is reduced in
Externí odkaz:
https://doaj.org/article/11a2840cdcf14a47a9c9ec9942c7fec9
Autor:
Ting Fu, Tao Huan, Gibraan Rahman, Hui Zhi, Zhenjiang Xu, Tae Gyu Oh, Jian Guo, Sally Coulter, Anupriya Tripathi, Cameron Martino, Justin L. McCarville, Qiyun Zhu, Fritz Cayabyab, Brian Low, Mingxiao He, Shipei Xing, Fernando Vargas, Ruth T. Yu, Annette Atkins, Christopher Liddle, Janelle Ayres, Manuela Raffatellu, Pieter C. Dorrestein, Michael Downes, Rob Knight, Ronald M. Evans
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112997- (2023)
Summary: Colorectal cancer (CRC) is driven by genomic alterations in concert with dietary influences, with the gut microbiome implicated as an effector in disease development and progression. While meta-analyses have provided mechanistic insight into
Externí odkaz:
https://doaj.org/article/958122a9c5d843b58513ee7535fcecb3
Autor:
Nuria Casanova-Vallve, Drew Duglan, Megan E. Vaughan, Marie Pariollaud, Michal K. Handzlik, Weiwei Fan, Ruth T. Yu, Christopher Liddle, Michael Downes, Julien Delezie, Rebecca Mello, Alanna B. Chan, Pål O. Westermark, Christian M. Metallo, Ronald M. Evans, Katja A. Lamia
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101504- (2022)
Objective: Exercise is a critical component of a healthy lifestyle and a key strategy for the prevention and management of metabolic disease. Identifying molecular mechanisms underlying adaptation in response to chronic physical activity is of critic
Externí odkaz:
https://doaj.org/article/855b431c342f44e185149aa1a1055a2d
Autor:
Clara Inkyung Lee, Siew Kee Low, Ricardo Maldonado, Peter Fox, Bavanthi Balakrishnar, Sally Coulter, Peter de Bruijn, Stijn L.W. Koolen, Bo Gao, Jodi Lynch, Nicholas Zdenkowski, Rina Hui, Christopher Liddle, Ron H.J. Mathijssen, Nicholas Wilcken, Mark Wong, Howard Gurney
Publikováno v:
Breast, Vol 54, Iss , Pp 229-234 (2020)
Introduction: CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E 35;
Externí odkaz:
https://doaj.org/article/ee0a0636acad496f8fd6fecf0cdfe594
Autor:
Carlos Perez Kerkvliet, Amy R. Dwyer, Caroline H. Diep, Robert H. Oakley, Christopher Liddle, John A. Cidlowski, Carol A. Lange
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-23 (2020)
Abstract Background Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor sensors. We previously reported that phospho-Ser134-GR (pS134-GR) species are elevated in triple-negative breast cancer (TNBC)
Externí odkaz:
https://doaj.org/article/1efbfc0a8b594b1c995949a1dcd4afbd
Autor:
Joseph M. Valentine, Maryam Ahmadian, Omer Keinan, Mohammad Abu-Odeh, Peng Zhao, Xin Zhou, Mark P. Keller, Hui Gao, Ruth T. Yu, Christopher Liddle, Michael Downes, Jin Zhang, Aldons J. Lusis, Alan D. Attie, Ronald M. Evans, Mikael Rydén, Alan R. Saltiel
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
The dysregulation of energy homeostasis in obesity involves multihormone resistance. Although leptin and insulin resistance have been well characterized, catecholamine resistance remains largely unexplored. Murine β3-adrenergic receptor expression i
Externí odkaz:
https://doaj.org/article/b1dd70c4674a48e3a86163d957e18958
Autor:
Mayada Metwally, Ali Bayoumi, Anis Khan, Leon A. Adams, Rocio Aller, Carmelo García-Monzón, María Teresa Arias-Loste, Elisabetta Bugianesi, Luca Miele, Alisi Anna, Olivier Latchoumanin, Shuanglin Han, Shafi Alenizi, Rasha EL Sharkawy, Afaf Elattar, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Christopher Liddle, Manuel Romero-Gomez, Jacob George, Mohammed Eslam
Publikováno v:
EBioMedicine, Vol 70, Iss , Pp 103521- (2021)
Background: Liver fibrosis risk is a heritable trait, the outcome of which is the net deposition of extracellular matrix by hepatic stellate cell-derived myofibroblasts. Whereas nucleotide sequence variations have been extensively studied in liver fi
Externí odkaz:
https://doaj.org/article/a06ae1d89aea4d04a07d0e81cd7b368f
Autor:
Ali Bayoumi, Asmaa Elsayed, Shuanglin Han, Salvatore Petta, Leon A. Adams, Rocio Aller, Anis Khan, Carmelo García‐Monzón, María Teresa Arias‐Loste, Luca Miele, Olivier Latchoumanin, Shafi Alenizi, Rocio Gallego‐Durán, Janett Fischer, Thomas Berg, Antonio Craxì, Mayada Metwally, Liang Qiao, Christopher Liddle, Hannele Yki‐Järvinen, Elisabetta Bugianesi, Manuel Romero‐Gomez, Jacob George, Mohammed Eslam
Publikováno v:
Advanced Science, Vol 8, Iss 11, Pp n/a-n/a (2021)
Abstract Fibroblast growth factor 21 (FGF21) is a liver‐derived hormone with pleiotropic beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic diseases. Interventions that restore metabolic homeostasis reduce FGF21
Externí odkaz:
https://doaj.org/article/ea7ae1ca7cda4ad490227a4f90944bd6