Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christopher, Kitson"'
Autor:
Christopher Kitson
Legacies of the Sublime offers a highly original, subtle and persuasive account of the aesthetics of the sublime in late nineteenth- and early twentieth-century literature, philosophy, and science. Christopher Kitson reveals the neglected history of
Publikováno v:
Connective tissue research. 60(1)
An imbalance of extracellular matrix (ECM) deposition and turnover is a hallmark of fibrotic pathologies as opposed to normal repair response to injury across several organs. Antifibrotic approaches to date have targeted multiple mechanisms and pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38237595aa44729b6d0811d5c216df15
https://pubmed.ncbi.nlm.nih.gov/30071759
https://pubmed.ncbi.nlm.nih.gov/30071759
Autor:
Alain Tissot, Seng-Lai Tan, Martin Bader, Stefan Seeber, Axel J. Hueber, Christopher Kitson, Johannes Auer, Jens Fischer, Stefan Lorenz, Stacy Wilson, Jörg Moelleken, Wolfgang Baum, Georg Schett, Margarete Galm
Publikováno v:
Arthritis & Rheumatology. 67:51-62
Objective Rheumatoid arthritis therapies that are based on inhibition of a single cytokine, e.g., tumor necrosis factor α (TNFα) or interleukin-6 (IL-6), produce clinically meaningful responses in only about half of the treated patients. This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c589d45c6d071e5e062c6541f9a05992
https://doi.org/10.1002/art.38896
https://doi.org/10.1002/art.38896
Autor:
Christopher Kitson, Xiaoyan Tang, Yonglin Ren, Qi Luo, Alan M. Holmes, Christopher P. Denton, Gaurav Tyagi, Rosario Garrido, Julie DeMartino, Christopher S. Stevenson, Cory M. Hogaboam, Subramanium Apparsundaram, Ruoqi Peng, David C. Budd, Maria E. Fuentes, Jeremy Deguzman, Jonathan E. Phillips, Carla M. T. Bauer
Publikováno v:
The American Journal of Pathology. 183:470-479
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of high unmet medical need. Although bromodomain (Brd) and extra terminal domain isoforms have recently been implicated in mediating inflammatory and oncologic indications, their roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62718916160e127818c8e709d69280c5
https://doi.org/10.1016/j.ajpath.2013.04.020
https://doi.org/10.1016/j.ajpath.2013.04.020
Autor:
Jayne Chin, Julie DeMartino, Shu Jin, Valerie Carvajal, Rupal Majmudar, Christopher Kitson, John Allard, Dori A. Thomas-Karyat, John Woods, Satwant K. Narula
Publikováno v:
International Immunology. 25:497-506
Organ transplant patients are often treated with immunosuppressants, such as the calcineurin phosphatase inhibitor, cyclosporin A, to block T cell-mediated graft rejection. The calcium release-activated calcium (CRAC/ORAI) channels, which act upstrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a7c79b4d0329421e0a067d63d8d8e7
https://doi.org/10.1093/intimm/dxt013
https://doi.org/10.1093/intimm/dxt013
Autor:
Christopher Kitson, Maria E. Fuentes, Luke Coyle, Yonglin Ren, Theresa Truitt, Subramaniam Apparsundaram, Jeremy Deguzman, Rachid Hamid, Yun Chen, Yimin Qian, Liang Guo, Rupal Majmudar, John Allard, David C. Budd, Xiaoyan Tang
Publikováno v:
Microvascular Research. 85:59-67
Lysophosphatidic acid (LPA) is a class of bioactive lyso-phospholipid that mediates most of its biological effects through a family of G protein-coupled receptors of which six have been identified. The role of the LPA pathway in driving chronic lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1b41c54a14e6daa8cbdb5bb95cac82
https://doi.org/10.1016/j.mvr.2012.10.004
https://doi.org/10.1016/j.mvr.2012.10.004
Autor:
Christopher Kitson, Yonglin Ren, Hang Zeng, Jeremy Deguzman, Julie DeMartino, Shannon Hamilton, Zhenmin Liang, David C. Budd, Christopher S. Stevenson, Subramanium Apparsundaram, Carla M. T. Bauer, Maria E. Fuentes, Ann F. Hoffman, Xiaoyan Tang, Ruoqi Peng
Publikováno v:
Molecular Pharmacology. 83:283-293
Epigenetic alterations, such as histone acetylation, regulate the signaling outcomes and phenotypic responses of fibroblasts after growth factor stimulation. The bromodomain and extra-terminal domain-containing proteins (Brd) bind to acetylated histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5bd7c22a859234c99d77dd94fdb4af
https://doi.org/10.1124/mol.112.081661
https://doi.org/10.1124/mol.112.081661
Autor:
Katrin F. Chua, Dan Levy, Alexander Tarakhovsky, Regina Cheung, Xiaodong Cheng, Yanqi Chang, Mark T. Bedford, Benjamin A. Garcia, Paul J. Utz, Andrew Kuo, Barry M. Zee, Rab K. Prinjha, Peggie Cheung, Ruth I. Tennen, Alexsandra Espejo, Or Gozani, Uwe Schaefer, Xiaobing Shi, Song Tanjing, Alex J. Kuo, Stephanie Tangsombatvisit, Christopher Kitson, Kevin Lee, Chih Long Liu
Publikováno v:
Nature Immunology. 12:29-36
Signaling via the methylation of lysine residues in proteins has been linked to diverse biological and disease processes, yet the catalytic activity and substrate specificity of many human protein lysine methyltransferases (PKMTs) are unknown. We scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2594eca7d0bcdc20e0861752fdd7cbf
https://doi.org/10.1038/ni.1968
https://doi.org/10.1038/ni.1968
Autor:
Jens A A, Fischer, Axel J, Hueber, Stacy, Wilson, Margarete, Galm, Wolfgang, Baum, Christopher, Kitson, Johannes, Auer, Stefan H, Lorenz, Jörg, Moelleken, Martin, Bader, Alain C, Tissot, Seng-Lai, Tan, Stefan, Seeber, Georg, Schett
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 67(1)
Rheumatoid arthritis therapies that are based on inhibition of a single cytokine, e.g., tumor necrosis factor α (TNFα) or interleukin-6 (IL-6), produce clinically meaningful responses in only about half of the treated patients. This study was under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ca10758546f486d0cb164a731b23f77
https://pubmed.ncbi.nlm.nih.gov/25348041
https://pubmed.ncbi.nlm.nih.gov/25348041
Autor:
Xiaoyan Tang, Ana Lucia J. Coelho, Maria E. Fuentes, Christopher Kitson, Sriram Sridhar, Jimmy Jung, Hans Bitter, Julie DeMartino, John Allard, David C. Budd, Cory M. Hogaboam, Fernando J. Martinez, Jeremy Deguzman
Publikováno v:
B66. THE FIBROBLAST POOL ON THE MOVE: DERIVATION AND TARGETING.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87f59c1ddeae5b2a161f8c17bd9551e0
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3499
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3499