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of 122
pro vyhledávání: '"Christopher, Cole"'
Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
Autor:
Matthew Gagne, Barbara J. Flynn, Christopher Cole Honeycutt, Dillon R. Flebbe, Shayne F. Andrew, Samantha J. Provost, Lauren McCormick, Alex Van Ry, Elizabeth McCarthy, John-Paul M. Todd, Saran Bao, I-Ting Teng, Shir Marciano, Yinon Rudich, Chunlin Li, Shilpi Jain, Bushra Wali, Laurent Pessaint, Alan Dodson, Anthony Cook, Mark G. Lewis, Hanne Andersen, Jiří Zahradník, Mehul S. Suthar, Martha C. Nason, Kathryn E. Foulds, Peter D. Kwong, Mario Roederer, Gideon Schreiber, Robert A. Seder, Daniel C. Douek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 has the capacity to evolve mutations that escape vaccine- and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent that protects against severe disease without putting selective pressure on the vir
Externí odkaz:
https://doaj.org/article/398a2dfd9ac6483f881f1a81f6f17840
Autor:
Honeycutt Christopher Cole, McDaniel Charles Griffin, McKnite Autumn, Hunt J. Porter, Whelan Aviva, Green Danielle J., Watt Kevin M.
Publikováno v:
The Journal of ExtraCorporeal Technology, Vol 55, Iss 4, Pp 159-166 (2023)
Background: Meropenem is a broad-spectrum carbapenem-type antibiotic commonly used to treat critically ill patients infected with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. As many of these patients require extracorporeal mem
Externí odkaz:
https://doaj.org/article/8ebb966bd28041599a98fa5a737fa1a5
Autor:
Ohad Yogev, Omer Weissbrod, Giorgia Battistoni, Dario Bressan, Adi Naamati, Ilaria Falciatori, Ahmet Can Berkyurek, Roni Rasnic, Rhys Izuagbe, Myra Hosmillo, Shaul Ilan, Iris Grossman, Lauren McCormick, Christopher Cole Honeycutt, Timothy Johnston, Matthew Gagne, Daniel C Douek, Ian Goodfellow, Gregory James Hannon, Yaniv Erlich
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A genome-wide screen of 16,471 RNAi triggers targeting SARS-CoV-2 genome by Sens.AI. identifies hyper-potent RNAi candidates against SARS-CoV-2 that are further validated in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/ff02faec80454a3f8bad5508748dbbd4
Autor:
Frazer Kirk, M.B.B.S., MSurg, Syed Danial Syed Ahmad, BMedSc, Clayton Lam, MD, BMedSc, GradCertPubHlt, Matthew S. Yong, M.B.B.S., PhD, FRACS, Cheng He, M.B.B.S., BMedSc, FRACS, Sumit Yadav, M.B.B.S., MS MCh C/Th, FRACS, Wing Lo, M.B.B.S., PhD, FRACS, Christopher Cole, BA, M.B.B.S., FRACS, Morgan Windsor, BMedSci, M.B.B.S.(Hons), FRACS, Rishendran Naidoo, MBCHB, MMed, FRACS, Andrie Stroebel, MBChB, MMed, FRACS
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 10, Pp 100567- (2023)
Introduction: Indigenous Australians (Aboriginal and Torres Strait Islander) have lower overall survival from lung cancer compared with nonindigenous Australians. Indigenous Australians receive higher rates of chemotherapy and/or radiotherapy. The eq
Externí odkaz:
https://doaj.org/article/0bb3b90bbd4a481eaec4a2c96f0346d0
Autor:
Dylan Scott Eiger, Noelia Boldizsar, Christopher Cole Honeycutt, Julia Gardner, Stephen Kirchner, Chloe Hicks, Issac Choi, Uyen Pham, Kevin Zheng, Anmol Warman, Jeffrey S. Smith, Jennifer Y. Zhang, Sudarshan Rajagopal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subcellular signaling is critical to generating cellular responses that modulate inflammatory pathways at the chemokine receptor CXCR3. Eiger et al. determine that agonist-biased CXCR3 signaling at endosomes differs from that at the plasma membrane,
Externí odkaz:
https://doaj.org/article/55e66e7cf24d40b4b499dd668c3d8704
Akademický článek
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Publikováno v:
In Energy & Buildings 15 January 2021 231
Autor:
Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Calcineurin is an essential virulence factor that is conserved across human fungal pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans. Although an excellent target for antifungal drug development, the s
Externí odkaz:
https://doaj.org/article/117f01418524456e8457bbd3d23cdecf
Autor:
Sophie M.-C. Gobeil, Benjamin G. Bobay, Praveen R. Juvvadi, D. Christopher Cole, Joseph Heitman, William J. Steinbach, Ronald A. Venters, Leonard D. Spicer
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so e
Externí odkaz:
https://doaj.org/article/0963e345cfb74f47bf957fdadaef28c6
Publikováno v:
Journal of Fungi, Vol 8, Iss 12, p 1281 (2022)
Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens. The immunosuppressive drugs, tacrolimus (FK506) and cyclosporin A (CsA), are fungistatic and specif
Externí odkaz:
https://doaj.org/article/6872ee6340a742b0881e3265c8ffab07