Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Christopher, Benyon"'
Autor:
John P. Iredale, R. Christopher Benyon, John N. Primrose, Graham Packham, Qian Xu, Andrew Papa-Adams, Thomas A. Armstrong, Adrian Bateman, Timothy J. Kendall, John A. Conti
CCR Translation on this Article from The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via αv Integrin Ligation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8f2b2dc61bbd5b30087689dd4ef700
https://doi.org/10.1158/1078-0432.22439599
https://doi.org/10.1158/1078-0432.22439599
Autor:
John P. Iredale, R. Christopher Benyon, John N. Primrose, Graham Packham, Qian Xu, Andrew Papa-Adams, Thomas A. Armstrong, Adrian Bateman, Timothy J. Kendall, John A. Conti
Purpose: The treatment of metastatic colorectal carcinoma represents a major clinical challenge. We investigated the hypothesis that the desmoplastic reaction within the liver elicited by metastatic adenocarcinoma, characterized by collagen I deposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a1ecc1da94beefa6a216df581b702c
https://doi.org/10.1158/1078-0432.c.6517039
https://doi.org/10.1158/1078-0432.c.6517039
Publikováno v:
The Scientific World Journal, Vol 1, Pp 119-119 (2001)
Externí odkaz:
https://doaj.org/article/f7ccfbedcb244dd7ac261b7cb89c8a83
Autor:
Antonella Pellicoro, Jonathan A. Fallowfield, Stephen N. Hartland, Jeremy S. Duffield, Victoria K. Snowdon, Stuart J. Forbes, R. Christopher Benyon, Andrew Robson, Madeleine A. Vernon, Rebecca L. Aucott, Prakash Ramachandran, John P. Iredale
Publikováno v:
Hepatology. 55:1965-1975
Elastin has been linked to maturity of liver fibrosis. To date, the regulation of elastin secretion and its degradation in liver fibrosis has not been characterized. The aim of this work was to define elastin accumulation and the role of the paradigm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9050ce508fa4793acda51524bccb87f2
https://doi.org/10.1002/hep.25567
https://doi.org/10.1002/hep.25567
Autor:
Rebecca L. Aucott, John P. Iredale, Selina Hennedige, Stephen N. Hartland, R. Christopher Benyon, Madeleine A. Vernon, Timothy J. Kendall
Publikováno v:
Hepatology. 49:901-910
Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis. We show that human hepatic myofibroblasts co-express p75NTR (p75 neurotrophin receptor) and sortilin, thus facilitating differential responses to mature and pro nerve growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c6211a8bebc2145194323e2cdecad1
https://doi.org/10.1002/hep.22701
https://doi.org/10.1002/hep.22701
Autor:
Nathan Trim, John P. Iredale, James Chan, Andrew Nash, Xiaoying Zhou, Aqeel Jamil, R. Christopher Benyon
Publikováno v:
Journal of Biological Chemistry. 281:39757-39765
Myofibroblastic-activated hepatic stellate cells are the major source of the collagen I-rich extracellular matrix in liver fibrosis but also produce matrix metalloproteinases, which remodel this protein. We have investigated the role of collagen I pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e07dc5eab581e9b63c1216d7b7176839
https://doi.org/10.1074/jbc.m605621200
https://doi.org/10.1074/jbc.m605621200
Autor:
Thomas Armstrong, John P. Iredale, David R. Fine, Lindsay B. Murphy, R. Christopher Benyon, Graham Packham, Adrian C Bateman, John A. Conti, Colin D. Johnson
Publikováno v:
Clinical Cancer Research. 10:7427-7437
Purpose: The purpose of this study was to determine the role of functional interactions between pancreatic cancer cells and pancreatic stellate cells (PSCs) in the formation of the desmoplastic reaction (DR) in pancreatic cancer and to characterize t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8509b7b465d2cd7e5718408baa33b35d
https://doi.org/10.1158/1078-0432.ccr-03-0825
https://doi.org/10.1158/1078-0432.ccr-03-0825
Autor:
John P. Iredale, Nitu Gehdu, Xiaoying Zhou, Junlong Zhang, Frank Murphy, R. Christopher Benyon
Publikováno v:
Journal of Biological Chemistry. 279:23996-24006
Hepatic stellate cells are the major source of the extracellular matrix that accumulates in fibrotic liver. During progressive liver fibrosis, hepatic stellate cells proliferate, but during resolution of fibrosis there is extensive stellate cell apop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9634f71c358c49f1ae05cffd1f87f209
https://doi.org/10.1074/jbc.m311668200
https://doi.org/10.1074/jbc.m311668200
Autor:
John P. Iredale, Christothea M. Constandinou, Kenneth J. Hillan, Derek A. Mann, R. Christopher Benyon, Timothy J. Kendall, Fiona Oakley, Nathan Trim, Alane M. Gray, Gretchen Frantz, Weilan Ye
Publikováno v:
The American Journal of Pathology. 163:1849-1858
A key feature of recovery from liver fibrosis is hepatic stellate cell (HSC) apoptosis, which serves the dual function of removing the major source of neomatrix and tissue inhibitors of metalloproteinases thereby facilitating matrix degradation. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89278a09fe23a6fa50adc8a2ff8ff2d4
https://doi.org/10.1016/s0002-9440(10)63544-4
https://doi.org/10.1016/s0002-9440(10)63544-4
Publikováno v:
European Journal of Biochemistry. 270:270-283
There has long been conjecture over the degree to which there may be structural and functional heterogeneity in the tetrameric serine protease tryptase (EC 3.4.21.59), a major mediator of allergic inflammation. We have applied 2D gel electrophoresis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40eb8ffd826589541625b6a1b8111a49
https://doi.org/10.1046/j.1432-1033.2003.03385.x
https://doi.org/10.1046/j.1432-1033.2003.03385.x