Výsledky vyhledávání - "Christophe Willems"

Inhibition of Notch signaling attenuates pituitary adenoma growth in Nude mice

Autor: Carolina Cristina, Catalina De Winne, I.M. Lacau-Mengido, Lautaro Zubeldia-Brenner, Damasia Becu-Villalobos, Hugo Vankelecom, Christophe Willems, Sofia Perrone, Santiago A. Rodríguez-Seguí, Ana Maria Ornstein

Preclinical and clinical studies support that Notch signaling may play an important oncogenic role in cancer, but there is scarce information for pituitary tumors. We therefore undertook a functional study to evaluate Notch participation in pituitary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bbb9ce66ded3f887cbc23aae009683
https://erc.bioscientifica.com/view/journals/erc/26/1/ERC-18-0337.xml

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Regeneration in the Pituitary After Cell-Ablation Injury: Time-Related Aspects and Molecular Analysis

Autor: Qiuli Fu, Hugo Vankelecom, Benoit Cox, Heleen Roose, Jianghai Chen, Christophe Willems, Freya Mertens

Publikováno v: Endocrinology. 157(2)

We recently showed that the mouse pituitary holds regenerative competence. Young-adult GHCre/iDTR mice, expressing diphtheria toxin (DT) receptor in GH-producing cells, regenerate the GH+ cells, as ablated by 3-day DT treatment (3DT), up to 60% after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93e7a42e748569748f52d10d17b258b
https://pubmed.ncbi.nlm.nih.gov/26828809

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Pituitary tumors contain a side population with tumor stem cell-associated characteristics

Autor: Qiuli Fu, Lies Gremeaux, Carolina Cristina, Marie Bex, Johannes van Loon, Hugo Vankelecom, Heleen Roose, Damasia Becu-Villalobos, Jianghai Chen, Tania Roskams, Christophe Willems, Olivier Govaere, Mark Jorissen, Freya Mertens, Vincent Vander Poorten

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Pituitary adenomas cause significant endocrine and mass-related morbidity. Little is known about the mechanisms that underlie pituitary tumor pathogenesis. In the present study, we searched for a side population (SP) in pituitary tumors representing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ec0feeda7a7c35f0378adceb8bca76
https://pubmed.ncbi.nlm.nih.gov/25921430

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Pituitary cell differentiation from stem cells and other cells: toward restorative therapy for hypopituitarism?

Autor: Hugo Vankelecom, Christophe Willems

Publikováno v: Regenerative medicine. 9(4)

The pituitary gland, key regulator of our endocrine system, produces multiple hormones that steer essential physiological processes. Hence, deficient pituitary function (hypopituitarism) leads to severe disorders. Hypopituitarism can be caused by def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec42c594ab73b26f1306ec96f223064
https://pubmed.ncbi.nlm.nih.gov/25159067

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