Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Christophe Trochet"'
Autor:
Elodie Rosinovsky, Catherine Caillet, Chiara Musiu, Jingyang Wang, Marie-Pierre Lioure, Arlène Roland, Luana Vargiu, Jocelyn Jakubik, Alistair Stewart, Michel Liuzzi, Richard Storer, Stéphanie Bot, Daniel Da Costa, Sébastien Maldonado, Barbara Poddesu, David Standring, Christophe Claude Parsy, Cyril B. Dousson, Christophe Trochet, Séverine Bonaric, Francois-Rene Alexandre, Maria Seifer, Adel Moussa, Benjamin Alexander Mayes, Agnès Amador, Luke Hubbard, Thierry Convard
Publikováno v:
Journal of Medicinal Chemistry. 59:1891-1898
Here, we describe the design, synthesis, biological evaluation, and identification of a clinical candidate non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a novel aryl-phospho-indole (APhI) scaffold. NNRTIs are recommended components of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176c9163cb45c8243cc2fc43da5fe84d
https://doi.org/10.1021/acs.jmedchem.5b01430
https://doi.org/10.1021/acs.jmedchem.5b01430
Autor:
Elodie Rosinovsky, Narayan Chaudhuri, Benjamin Alexander Mayes, Christophe Trochet, Steven Mathieu, G. Mark Latham, Alistair Stewart, Adel Moussa, Jie Li, Jeevanandam Arumugasamy, Alan Becker, Erkan Baloglu, F. Patrick McGarry, Jingyang Wang, David Bauer
Publikováno v:
Organic Process Research & Development. 18:717-724
A synthetic process for 2′-C-methylcytidine-5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate], a nucleotide prodrug inhibitor of hepatitis C virus NS5B polymerase, is described. The route developed was demonstrated on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6560b20a8c693f5283f4af20fa03985c
https://doi.org/10.1021/op500042u
https://doi.org/10.1021/op500042u