Model-based assessment of mammalian cell metabolic functionalities using omics data

Autor: Anne Richelle, Benjamin P. Kellman, Alexander T. Wenzel, Austin W.T. Chiang, Tyler Reagan, Jahir M. Gutierrez, Chintan Joshi, Shangzhong Li, Joanne K. Liu, Helen Masson, Jooyong Lee, Zerong Li, Laurent Heirendt, Christophe Trefois, Edwin F. Juarez, Tyler Bath, David Borland, Jill P. Mesirov, Kimberly Robasky, Nathan E. Lewis

Publikováno v: Cell Reports: Methods, Vol 1, Iss 3, Pp 100040- (2021)

Summary: Omics experiments are ubiquitous in biological studies, leading to a deluge of data. However, it is still challenging to connect changes in these data to changes in cell functions because of complex interdependencies between genes, proteins,

Externí odkaz: https://doaj.org/article/c23044d9a67944aeafbcd03821f78050

The need for standardisation in life science research - an approach to excellence and trust. [version 1; peer review: 2 approved]

Autor: Susanne Hollmann, Andreas Kremer, Špela Baebler, Christophe Trefois, Kristina Gruden, Witold R. Rudnicki, Weida Tong, Aleksandra Gruca, Erik Bongcam-Rudloff, Chris T. Evelo, Alina Nechyporenko, Marcus Frohme, David Šafránek, Babette Regierer, Domenica D'Elia

Publikováno v: F1000Research, Vol 9 (2020)

Today, academic researchers benefit from the changes driven by digital technologies and the enormous growth of knowledge and data, on globalisation, enlargement of the scientific community, and the linkage between different scientific communities and

Externí odkaz: https://doaj.org/article/d744d3a2336b41dca53c273c146fdff9

Model-based assessment of mammalian cell metabolic functionalities using omics data

Autor: Jooyong Lee, Jill P. Mesirov, Chintan Joshi, Christophe Trefois, Nathan E. Lewis, Alexander T. Wenzel, Zerong Li, Edwin F. Juarez, David Borland, Tyler Bath, Austin W. T. Chiang, Laurent Heirendt, Tyler Reagan, Jahir M. Gutierrez, Joanne K. Liu, Benjamin P. Kellman, Anne Richelle, Shangzhong Li, Helen O. Masson, Kimberly Robasky

Publikováno v: Cell Reports: Methods, Vol 1, Iss 3, Pp 100040-(2021)
Cell reports methods

SUMMARY Omics experiments are ubiquitous in biological studies, leading to a deluge of data. However, it is still challenging to connect changes in these data to changes in cell functions because of complex interdependencies between genes, proteins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b194eb4ec8b147cd8d68c3a97d3163
http://www.sciencedirect.com/science/article/pii/S2667237521000850

GigaSOM.jl: High-performance clustering and visualization of huge cytometry datasets

Autor: Markus Ollert, Oliver Hunewald, Reinhard Schneider, Laurent Heirendt, Venkata P. Satagopam, Vasco Verissimo, Jiří Vondrášek, Christophe Trefois, Miroslav Kratochvíl

Publikováno v: GigaScience
Kratochvíl, M, Hunewald, O, Heirendt, L, Verissimo, V, Vondrášek, J, Satagopam, V P, Schneider, R, Trefois, C & Ollert, M 2020, ' GigaSOM.jl : High-performance clustering and visualization of huge cytometry datasets ', GigaScience, vol. 9, no. 11, giaa127 . https://doi.org/10.1093/gigascience/giaa127

BackgroundThe amount of data generated in large clinical and phenotyping studies that use single-cell cytometry is constantly growing. Recent technological advances allow to easily generate data with hundreds of millions of single-cell data points wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98af6d38058edc1931c3a9bc2e8f936
https://pubmed.ncbi.nlm.nih.gov/33205814

Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability

Autor: Rudi Balling, Olga Boyd, Julia Ilona Forster, Paul Antony, Aidos Baumuratov, Sandra Köglsberger, L. Buck, Christophe Trefois

Publikováno v: Journal of Biomolecular Screening

The immortalized and proliferative cell line SH-SY5Y is one of the most commonly used cell lines in neuroscience and neuroblastoma research. However, undifferentiated SH-SY5Y cells share few properties with mature neurons. In this study, we present a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82eb219317ccb7c255428558a589083
https://doi.org/10.1177/1087057115625190