Synthesis and antiproliferative activity of benzofuran-based analogs of cercosporamide against non-small cell lung cancer cell lines

Autor: Lizeth Bodero, Marc-Antoine Bazin, Pascal Marchand, Bénédicte Rousseau, Christos Roussakis, Christophe Tomasoni

Publikováno v: European Journal of Medicinal Chemistry. 69:823-832

A novel series of 3-methyl-1-benzofuran derivatives were synthesized and screened in vitro for their antiproliferative activity against two human NSCLC cell lines (NSCLC-N6 mutant p53 and A549 wild type p53). Most promising compounds presented a stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534d508a4ead5566f9f99e43a4d4c187
https://doi.org/10.1016/j.ejmech.2013.09.013

Discovery of Novel (Imidazo[1,2-a]pyrazin-6-yl)ureas as Antiproliferative Agents Targeting P53 in Non-small Cell Lung Cancer Cell Lines

Autor: Marc-Antoine, Bazin, Bénédicte, Rousseau, Sophie, Marhadour, Christophe, Tomasoni, Pierre, Evenou, Sylvie, Piessard, Abraham J, Vaisberg, Sandrine, Ruchaud, Stéphane, Bach, Christos, Roussakis, Pascal, Marchand

Publikováno v: Anticancer research. 36(4)

A series of (imidazo[1,2-a]pyrazin-6-yl)ureas were synthesized through 6-aminoimidazo[1,2-a]pyrazine as a key intermediate. 1-(Imidazo[1,2-a]pyrazin-6-yl)-3-(4-methoxy - phenyl)urea displayed a cytostatic activity against a non-small cell lung cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f741dc1da207ea8db7a612723914b288
https://pubmed.ncbi.nlm.nih.gov/27069139

TP53 transcription factor for the NEDD9/HEF1/Cas-L gene: potential targets in Non-Small Cell Lung Cancer treatment

Autor: Bénédicte Rousseau, Catherine Jacquot, Christos Roussakis, Marine Malleter, Tifenn Boutard, Vehary Sakanyan, Christophe Tomasoni, Julie Le Palabe

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, 5 (1), pp.10356. ⟨10.1038/srep10356⟩
Scientific Reports, 2015, 5 (1), pp.10356. ⟨10.1038/srep10356⟩

Lung cancer is a serious public health problem. Although there has been significant progress in chemotherapy, non-small cell lung cancer is still resistant to current treatments, primarily because of the slow rate of cell development. It is thus impo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2da94084f3235efd6ca8d578c803d05
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01165439/document

Cucurbitacin-D-induced CDK1 mRNA up-regulation causes proliferation arrest of a non-small cell lung carcinoma cell line (NSCLC-N6)

Autor: Catherine, Jacquot, Benedicte, Rousseau, Delphine, Carbonnelle, Ioanna, Chinou, Marine, Malleter, Christophe, Tomasoni, Christos, Roussakis

Publikováno v: Anticancer research. 34(9)

Despite progress in chemotherapeutic agents, non-small cell lung cancers (NSCLC) still have a poor survival rate. Thus, development of new therapeutic strategies, specifically against cancer cells is still required. For this purpose, we treated the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1113a017026b505ed23412a5c5cc4a16
https://pubmed.ncbi.nlm.nih.gov/25202060

A novel large regulator RNA, B2, partially overlaps the HEF1/NEDD9/Cas-L gene

Autor: Christos Roussakis, Dimitri Moreau, Patrice Le Pape, Christophe Tomasoni, Ioanna Chinou, Catherine Jacquot, Marianna Tsvetanova, Marcel Juge, Alain Pineau, Marine Malleter

Publikováno v: International Journal of Molecular Medicine. 25

The non-coding RNAs are new players in cellular and molecular biology. Indeed, quantitative and functional non-coding RNA has long been underestimated. There is a great diversity and it seems that much of the genome is transcribed into RNA, while onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8d7ac750e569210feb4c82f1ad4a44
https://doi.org/10.3892/ijmm_00000420