Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Christophe Romier"'
Autor:
Marina Vitoria Gomes, Pauline Landwerlin, Marie-Laure Diebold-Durand, Tajith B. Shaik, Alexandre Durand, Edouard Troesch, Chantal Weber, Karl Brillet, Marianne Victoria Lemée, Christophe Decroos, Ludivine Dulac, Pierre Antony, Erwan Watrin, Eric Ennifar, Christelle Golzio, Christophe Romier
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114656- (2024)
Summary: Cohesin is key to eukaryotic genome organization and acts throughout the cell cycle in an ATP-dependent manner. The mechanisms underlying cohesin ATPase activity are poorly understood. Here, we characterize distinct steps of the human cohesi
Externí odkaz:
https://doaj.org/article/ca753347721b4c14a2cbed22d5bf7651
Autor:
Eloise Pavão Guerra-Slompo, Gisele Fernanda Assine Picchi-Constante, Martin Marek, Christophe Romier, Wolfgang Sippl, Nilson Ivo Tonin Zanchin
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102058- (2023)
Summary: Here, we describe a combined in cellulo and in vivo approach to identify compounds with higher potential for efficient inhibition of Trypanosoma cruzi. Phase I of in cellulo assays is designed to exclude inactive or toxic compounds, while ph
Externí odkaz:
https://doaj.org/article/a6ce12f930fd45ce85f6f3a2270026cc
Autor:
Gisele Fernanda Assine Picchi-Constante, Priscila Mazzocchi Hiraiwa, Martin Marek, Vanessa Zulkievicz Rogerio, Eloise Pavão Guerra-Slompo, Christophe Romier, Nilson Ivo Tonin Zanchin
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101324- (2022)
Summary: This protocol outlines a new genetic complementation strategy to investigate gene function in Trypanosoma cruzi, the parasite causing Chagas disease. We combine CRISPR-Cas9 technology with recombination of variants of the target gene contain
Externí odkaz:
https://doaj.org/article/5233e0e1faa14a838c7f1926e6da97ab
Autor:
Sébastien Coassolo, Guillaume Davidson, Luc Negroni, Giovanni Gambi, Sylvain Daujat, Christophe Romier, Irwin Davidson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Pyruvate kinase M2 (PKM2) activity is regulated by the availability of metabolic intermediates for nucleotide and amino acid synthesis. Here, the authors show that PKM2 citrullination by PADI1 and PADI3 lowers its sensitivity to metabolic inhibitors
Externí odkaz:
https://doaj.org/article/abe0909d891949838e266bade71dfb62
Autor:
Conrad V. Simoben, Ehab Ghazy, Patrik Zeyen, Salma Darwish, Matthias Schmidt, Christophe Romier, Dina Robaa, Wolfgang Sippl
Publikováno v:
Molecules, Vol 26, Iss 9, p 2584 (2021)
Histone-modifying proteins have been identified as promising targets to treat several diseases including cancer and parasitic ailments. In silico methods have been incorporated within a variety of drug discovery programs to facilitate the identificat
Externí odkaz:
https://doaj.org/article/edd89b2960de48afbd863c854771fa46
Autor:
Letícia Anderson, Monete Rajão Gomes, Lucas Ferreira daSilva, Adriana da Silva Andrade Pereira, Marina M Mourão, Christophe Romier, Raymond Pierce, Sergio Verjovski-Almeida
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005539 (2017)
BACKGROUND:Schistosomiasis is a parasitic disease infecting hundreds of millions of people worldwide. Treatment depends on a single drug, praziquantel, which kills the Schistosoma spp. parasite only at the adult stage. HDAC inhibitors (HDACi) such as
Externí odkaz:
https://doaj.org/article/2b0ac833577647d8aded8ea98023a28e
Autor:
Conrad V. Simoben, Dina Robaa, Alokta Chakrabarti, Karin Schmidtkunz, Martin Marek, Julien Lancelot, Srinivasaraghavan Kannan, Jelena Melesina, Tajith B. Shaik, Raymond J. Pierce, Christophe Romier, Manfred Jung, Wolfgang Sippl
Publikováno v:
Molecules, Vol 23, Iss 3, p 566 (2018)
A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening procedure using the crysta
Externí odkaz:
https://doaj.org/article/73b1ffb88c724f2986fdfd1e0f2763f9
Autor:
Daniil Alpern, Diana Langer, Benoit Ballester, Stephanie Le Gras, Christophe Romier, Gabrielle Mengus, Irwin Davidson
Publikováno v:
eLife, Vol 3 (2014)
The functions of the TAF subunits of mammalian TFIID in physiological processes remain poorly characterised. In this study, we describe a novel function of TAFs in directing genomic occupancy of a transcriptional activator. Using liver-specific inact
Externí odkaz:
https://doaj.org/article/a7b7436051f44742b4dbc3c3a46aefdd
Autor:
Martin Marek, Srinivasaraghavan Kannan, Alexander-Thomas Hauser, Marina Moraes Mourão, Stéphanie Caby, Vincent Cura, Diana A Stolfa, Karin Schmidtkunz, Julien Lancelot, Luiza Andrade, Jean-Paul Renaud, Guilherme Oliveira, Wolfgang Sippl, Manfred Jung, Jean Cavarelli, Raymond J Pierce, Christophe Romier
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003645 (2013)
The treatment of schistosomiasis, a disease caused by blood flukes parasites of the Schistosoma genus, depends on the intensive use of a single drug, praziquantel, which increases the likelihood of the development of drug-resistant parasite strains a
Externí odkaz:
https://doaj.org/article/8177e77a4c194daa95e03dd903b2b7f5
Autor:
Ping Sun, Jing Wang, Khadija S. Khan, Weiqin Yang, Billy Wai-Lung Ng, Nikita Ilment, Matthes Zessin, Emre F. Bülbül, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Mike Schutkowski, Alfred Sze-Lok Cheng, Wolfgang Sippl
Publikováno v:
Journal of Medicinal Chemistry. 65:16313-16337
Histone deacetylases (HDACs) are epigenetic regulators and additionally control the activity of non-histone substrates. We recently demonstrated that inhibition of HDAC8 overexpressed in various of cancers reduces hepatocellular carcinoma tumorigenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c985e4087f311b0e6b58dd9531d9764
https://doi.org/10.1021/acs.jmedchem.2c01132
https://doi.org/10.1021/acs.jmedchem.2c01132