Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christophe R. Laroche"'
Publikováno v:
Tetrahedron. 70:4534-4539
Regiocontrolled cyclizations involving alkynes have utility in the formation of diverse heterocyclic systems. Here we report the participation of model 1-alkynylimidazoles in intramolecular hydroalkoxylation and hydroamination reactions leading to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cda69ea814af2c1f0640571d2c07e6e
https://doi.org/10.1016/j.tet.2014.04.099
https://doi.org/10.1016/j.tet.2014.04.099
Publikováno v:
Journal of Medicinal Chemistry. 54:5059-5069
A new class of potential antitumor agents inspired by the enediyne antitumor antibiotics has been synthesized: the 1,2-dialkynylimidazoles. The aza-Bergman rearrangement of these 1,2-dialkynylimidazoles has been investigated theoretically at the B3LY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1711961e79953d9a7fd301629d4c10a
https://doi.org/10.1021/jm200289j
https://doi.org/10.1021/jm200289j
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6293-6297
Based on the mild, thermal rearrangement of 1,2-dialkynylimidazoles to reactive carbene or diradical intermediates, a series of 1,2-dialkynylimidazoles were designed as potential irreversible p38 MAP kinase alpha-isoform (p38alpha) inhibitors. The sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9ceb573c4102d51292f4b5825a5655
https://doi.org/10.1016/j.bmcl.2009.09.094
https://doi.org/10.1016/j.bmcl.2009.09.094
Autor:
Sean M. Kerwin, Christophe R. Laroche
Publikováno v:
Tetrahedron Letters. 50:5194-5197
Functionalization reactions of 1-alkynylimidazoles involving the formation of their 2-lithio derivatives followed by addition of various electrophiles are presented. This allows access to previously unreported 1,2-dialkynylimidazoles via 1-alkynyl-2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4fb4a2df6e073ce9b0aed86d8249b0d
https://doi.org/10.1016/j.tetlet.2009.06.133
https://doi.org/10.1016/j.tetlet.2009.06.133
Autor:
Philippe Bertus, Pierre Vogel, Christophe R. Laroche, Catherine Schütz, Jean-Bernard Behr, Richard Plantier-Royon, Jan Szymoniak
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:4047-4054
Polyhydroxy 4-azaspiro[2.4]heptane derivatives (spirocyclopropyl iminosugars) were prepared in four to six steps from readily available protected aldoses. The key step of the reaction sequence involves a titanium-mediated aminocyclopropanation of gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dc5981e15f8a54c18e730cb4a7e495
https://doi.org/10.1016/j.bmc.2006.02.005
https://doi.org/10.1016/j.bmc.2006.02.005
Autor:
Christophe R. Laroche, Jan Szymoniak, Richard Plantier-Royon, Jean-Bernard Behr, Philippe Bertus
Publikováno v:
Synlett. :223-226
The synthesis of the first spirocyclopropyl iminosugar has been achieved in six steps and 13% overall yield from commercially available 2,3,5-tri-O-benzyl-D-arabinose. The synthesis is based on an efficient two-step reaction involving the titanium-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7b4bc72e06418eaff12a25bf57f633
https://doi.org/10.1055/s-2005-923582
https://doi.org/10.1055/s-2005-923582
Autor:
Philippe Bertus, Christophe R. Laroche, Richard Plantier-Royon, Jean-Bernard Behr, Jan Szymoniak
Publikováno v:
European Journal of Organic Chemistry. 2005:5084-5088
Carbohydrates bearing aminocyclopropyl moieties were conveniently prepared from the corresponding nitriles by titanium-mediated addition of Grignard reagents. A wide range of protective groups are tolerated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ee55233f8d536653be092a4f0ea1e4
https://doi.org/10.1002/ejoc.200500406
https://doi.org/10.1002/ejoc.200500406
Publikováno v:
Tetrahedron. 60:1375-1383
A variety of 2,4-pentadienylzirconiums were generated by reacting pentadienyl ethers with zirconocene ‘Cp2Zr’. These complexes underwent a highly γ-regioselective and anti-stereoselective in situ addition with carbonyl compounds to afford bis(ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9abbba98adf5f4404f96310b7669ade
https://doi.org/10.1016/j.tet.2003.08.065
https://doi.org/10.1016/j.tet.2003.08.065
Publikováno v:
Tetrahedron Letters. 43:2827-2830
The reaction of chiral 2-trifluoromethyl-1,3-oxazolidines with various silylated nucleophiles under Lewis acid activation provides a stereoselective route to functionalized α-trifluoromethylamines. This methodology was successfully applied to the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a65d6f9237714adfe4f888e18cb99ca9
https://doi.org/10.1016/s0040-4039(02)00330-1
https://doi.org/10.1016/s0040-4039(02)00330-1
Publikováno v:
ChemInform. 45
Regiocontrolled cyclizations involving alkynes have utility in the formation of diverse heterocyclic systems. Here we report the participation of model 1-alkynylimidazoles in intramolecular hydroalkoxylation and hydroamination reactions leading to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3ffbafb804a5d165315cc9abc779250
https://doi.org/10.1002/chin.201450034
https://doi.org/10.1002/chin.201450034