Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christophe Philippo"'
Autor:
Stephane Illiano, Bruno Poirier, Claire Minoletti, Olivier Pasquier, Laurence Riva, Xavier Chenede, Isabelle Menguy, Michel Guillotel, Philippe Prigent, Stéphane Le Claire, Florence Gillot, Gilbert Thill, François Lo Presti, Alain Corbier, Jean-Christophe Le Bail, Patrick Grailhe, Edith Monteagudo, Raffaele Ingenito, Elisabetta Bianchi, Christophe Philippo, Olivier Duclos, Sergio Mallart, Ross Bathgate, Philip Janiak
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Despite beneficial effects in acute heart failure, the full therapeutic potential of recombinant relaxin-2 has been hampered by its short half-life and the need for intravenous administration limiting its use to intensive care units. A multi
Externí odkaz:
https://doaj.org/article/9680bc4f067244f5859525deb060514b
Autor:
Christophe Philippo, Jean-Christophe Le Bail, Bruno Cornet, Pascale Briand, Pascal Paul, Philip Janiak, Etienne Guillot, Valerie Fourgous, Michel Partiseti
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:283-294
Lysophosphatidic acid (LPA) is the natural ligand for two phylogenetically distinct families of receptors (LPA1-3, LPA4-6) whose pathways control a variety of physiologic and pathophysiological responses. Identifying the benefit of balanced activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8979ed336011fbc08acf3bf4d7ea0d9e
https://doi.org/10.1124/jpet.120.265454
https://doi.org/10.1124/jpet.120.265454
Autor:
Christophe Henry, Philippe Péron, Anne-Marie Blanchet, Arielle Genevois-Borella, Marc Trellu, Dorothée Bourges, Philippe Lienard, Alexandra Basset, Erwan Jouannot, Christophe Philippo, Laurent Debussche, Jürgen Moll
Publikováno v:
Cancer Research. 82:130-130
xCT is a cystine/glutamate antiporter that exports intracellular glutamate for extracellular cystine. In the intracellular space, cystine is converted into cysteine which is subsequently used for glutathione (GSH) synthesis (a major antioxidant speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be340049e3251319a582741903a08969
https://doi.org/10.1158/1538-7445.am2022-130
https://doi.org/10.1158/1538-7445.am2022-130
Autor:
Philippe Péron, Marie-Aude Chabanaud, Gwladys Langot, Etienne Guillot, Florence Goumy, Patrick Mougenot, Cecile Pascal, Olivier Crespin, Fabrice Viviani, Majdi Ben-Hassine, Friedemann Schmidt, Eykmar Fett, Jean-Christophe Le Bail, Jean-Luc Ragot, Bénédicte Onofri, Rommel Dadji-Faïhun, Christophe Philippo, Thao Van-Pham, Catherine Monseau, Olivier Venier, Jerome Menegotto, Florence Chatelain-Egger, Marie-Pierre Pruniaux, François Pacquet, Philippe Chamiot-Clerc, Eric Nicolai, Claudie Namane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:25-32
Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccd83610869fd9f5432e155ed4fbc2f
https://doi.org/10.1016/j.bmcl.2015.11.046
https://doi.org/10.1016/j.bmcl.2015.11.046
Autor:
Jean-Luc Ragot, Catherine Monseau, Cecile Pascal, Alain Braun, Lionel Noah, Thao Van-Pham, Rommel Dadji-Faïhun, Majdi Ben-Hassine, Olivier Venier, Géraldine Farjot, Patrick Mougenot, Eric Nicolai, Claudie Namane, Christophe Philippo, Olivier Crespin, Cécile Mougenot, Bénédicte Onofri, Stefan Gussregen, Karima Maniani, Christian Engel, François Pacquet, Céline Leger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2244-2251
A High Throughput Screening campaign allowed the identification of a novel class of ureas as 11β-HSD1 inhibitors. Rational chemical optimization provided potent and selective inhibitors of both human and murine 11β-HSD1 with an appropriate ADME pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a453306e9f16edd9c82b584b9c9e2ff5
https://doi.org/10.1016/j.bmcl.2011.02.111
https://doi.org/10.1016/j.bmcl.2011.02.111
Autor:
Christophe Philippo, Alain Braun, Gerard Defosse, Stephanie Auboussier, Patrick Mougenot, Philippe R Bovy
Publikováno v:
Synthesis. 2000:127-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93044ea50bd07d2ab42e06ec7869057c
https://doi.org/10.1055/s-2000-6237
https://doi.org/10.1055/s-2000-6237
Publikováno v:
European Journal of Medicinal Chemistry. 32:881-888
Summary Both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methylethoxy)phenyl)ethanol were synthetized by a stereoselective route and evaluated in vitro for their uroselectivity in comparison with other α1-adrenoceptor agonists. The most poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7ff47231f642d7494e7a4bb0223793f
https://doi.org/10.1016/s0223-5234(97)82773-0
https://doi.org/10.1016/s0223-5234(97)82773-0
Autor:
Anja Pfenninger, Marc Dietrich Voss, Claudie Namane, Markus Kohlmann, Zoller Gerhard, Andreas W. Herling, Christophe Philippo, Hans Matter, Juan-Antonio Sanchez-Arias
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(6)
The discovery of potent benzimidazole stearoyl-CoA desaturase (SCD1) inhibitors by ligand-based virtual screening is described. ROCS 3D-searching gave a favorable chemical motif that was subsequently optimized to arrive at a chemical series of potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5333b6e9303648315704d26afba9b177
https://pubmed.ncbi.nlm.nih.gov/23395660
https://pubmed.ncbi.nlm.nih.gov/23395660
Autor:
Friedemann Schmidt, Philippe Péron, Jean-Luc Ragot, Thao Van-Pham, Marie-Aude Chabanaud, Jean-Christophe Le Bail, Olivier Venier, Eric Nicolai, Claudie Namane, Bénédicte Onofri, Majdi Ben-Hassine, Patrick Mougenot, Rommel Dadji-Faïhun, François Pacquet, Philippe Chamiot-Clerc, Cecile Pascal, Catherine Monseau, Etienne Guillot, Christophe Philippo, Florence Camy, Olivier Crespin, Florence Chatelain-Egger, Marie-Pierre Pruniaux, Fabrice Viviani, Gwladys Langot, Eykmar Fett
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(7)
A novel class of DGAT1 inhibitors containing a thiadiazole core has been discovered. Chemical optimization lead to inhibitors of human DGAT1 with an appropriate ADME profile and that show in vivo activity in target tissues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95f9ebac9a8634e4ef820a9b0efd6c1
https://pubmed.ncbi.nlm.nih.gov/22405833
https://pubmed.ncbi.nlm.nih.gov/22405833
Publikováno v:
ChemInform. 29
Summary Both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methylethoxy)phenyl)ethanol were synthetized by a stereoselective route and evaluated in vitro for their uroselectivity in comparison with other α1-adrenoceptor agonists. The most poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee7bf991deb49df8ea26a1eeaaa99ce
https://doi.org/10.1002/chin.199813086
https://doi.org/10.1002/chin.199813086