Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Christophe P G, Gerald"'
Autor:
Douglas Marsteller, Indira Mendez, Bruno P. Guiard, Irina Antonijevic, Denis J. David, Roman Artymyshyn, Jean-Philippe Guilloux, Michael R. Drew, Benjamin Adam Samuels, Alain M. Gardier, E. David Leonardo, Quentin Rainer, Douglas A. Craig, René Hen, Jingwen Wang, Christophe P. G. Gerald
Publikováno v:
Neuron. 62(4):479-493
Summary Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of the disease. Here we describe a mouse model of an anxiety/depressive-like state in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7305e6949dc80fd8ff3d0d17d236b96
Autor:
Mariusz Papp, Toni D. Wolinsky, Xiaoli Ping, Daniel G. Smith, Christophe P. G. Gerald, Douglas A. Craig, Laxminarayan G. Hegde, Silke Miller, Tanya Edwards
Publikováno v:
Behavioural Brain Research. 197:284-291
Melanin-concentrating hormone (MCH) is an orexigenic and dipsogenic neuropeptide that has been reported to mediate acute behavioral and neuroendocrine stress-related responses via MCH 1 receptor activation in rodents. The purpose of the present inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c020cd45130a3ccdba85b44cbd5f2e71
https://doi.org/10.1016/j.bbr.2008.08.026
https://doi.org/10.1016/j.bbr.2008.08.026
Autor:
Laxminarayan G. Hegde, Mary W. Walker, Vrej Jubian, Mariusz Papp, Mohammad R. Marzabadi, Douglas A. Craig, Christophe P. G. Gerald, David H. Overstreet, Silke Miller, Gamini Chandrasena, Huailing Zhong, Toni D. Wolinsky, Douglas A. Marsteller, Xinyan Huang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:900-911
Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y1, Y2, Y4, Y5, and y6). The Y5 receptor is well known for its role in appetite. Based on expression in the limbic system, we hypothesized that the Y5 receptor might also m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152b8da161e9f077a50457dd9cc641dc
https://doi.org/10.1124/jpet.108.144634
https://doi.org/10.1124/jpet.108.144634
Autor:
D. Dong, C. J. Swanson, Kristen C. Klemenhagen, Luca Santarelli, Huailing Zhong, Laxminarayan G. Hegde, Michael Saxe, Indira Mendez, Douglas A. Craig, Mohammad R. Marzabadi, Denis J. David, Christophe P. G. Gerald, René Hen, K. A. Holick, X. I. Ping
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:237-248
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that plays a role in the modulation of food intake and mood. In rodents, the actions of MCH are mediated via the MCHR1 receptor. The goal of this study was to investigate the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea4f538fd03ef2199b641dabbcd8a3d
https://doi.org/10.1124/jpet.106.109678
https://doi.org/10.1124/jpet.106.109678
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 3:467-473
Current anti-depressant treatments do not completely fulfill our expectations in terms of efficacy, onset of action and side effects. For decades, both industrial and academic groups have struggled to identify alternative treatments acting through no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29e3bcffa1283d8cd494f6fdece3b371
https://doi.org/10.1016/j.ddstr.2006.11.010
https://doi.org/10.1016/j.ddstr.2006.11.010
Autor:
Joseph A. Tamm, Noel Boyle, Pierre J.-J. Vaysse, Nika Adham, Wen-Jeng Yao, Carlos Forray, John M. Wetzel, Parul P. Lakhlani, Margaret M. Durkin, Roman Artymyshyn, Evguenia V. Kouranova, Yong Quan, Kelli E. Smith, Kenneth A. Jones, Rita Raddatz, Theresa Branchek, Christophe P. G. Gerald, James A. Bonini, Kristine L. Ogozalek, Lakmal W. Boteju, Beth Borowsky
Publikováno v:
Journal of Biological Chemistry. 275:39324-39331
The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from human and rat central nervous system tissues. NPF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5a488ab332b9fe290d764d964bd5d1
https://doi.org/10.1074/jbc.m004385200
https://doi.org/10.1074/jbc.m004385200
Autor:
Theresa Branchek, Lakmal W. Boteju, Raisa Nagorny, Rita Raddatz, Maricel S. Guevarra, Beth Borowsky, Christophe P. G. Gerald, Gabriel S. Lerman, Evguenia V. Kouranova, Amy E. Wilson, Pierre J.-J. Vaysse, Siqun Zhou, Carlos Forray, Nika Adham, Meng Dai, Roman Artymyshyn, James A. Bonini
Publikováno v:
Journal of Biological Chemistry. 275:32452-32459
Two structurally related, G-protein-coupled receptors were identified as receptors for the neuropeptide, neuromedin U. This peptide is found in highest levels in the gut and genitourinary system where it potently contracts smooth muscle but is also e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6e285f2285774657abe34f6411afc6
https://doi.org/10.1074/jbc.m004613200
https://doi.org/10.1074/jbc.m004613200
Autor:
Christophe P. G. Gerald, Kelli E. Smith, Theresa Branchek, Eric L. Gustafson, Mary W. Walker, Margaret M. Durkin
Publikováno v:
Experimental Neurology. 165:90-100
Our group has reported on the cloning of a novel rat neuropeptide Y (NPY) receptor involved in NPY-induced food intake, the Y5 receptor. The distribution in rat brain of the mRNA encoding this receptor has been determined by in situ hybridization his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c5d13130d8466127aa3b4fe85e6108
https://doi.org/10.1006/exnr.2000.7446
https://doi.org/10.1006/exnr.2000.7446
Autor:
Pierre J.-J. Vaysse, Jonathan A. Bard, Wen-Jeng Yao, Christophe P. G. Gerald, Roman Artymyshyn, Beth Borowsky, Kelli E. Smith, Joseph A. Tamm, Theresa Branchek, Mary W. Walker, Kenneth A. Jones
Publikováno v:
Journal of Biological Chemistry. 273:23321-23326
The neuropeptide galanin has been implicated in the regulation of processes such as nociception, cognition, feeding behavior, and hormone secretion. Multiple galanin receptors are predicted to mediate its effects, but only two functionally coupled re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9bd37bf546696b371e37cc270d74773
https://doi.org/10.1074/jbc.273.36.23321
https://doi.org/10.1074/jbc.273.36.23321
Autor:
Christophe P. G. Gerald, Jonathan A. Bard, Kelli E. Smith, Beth Borowsky, Kenneth A. Jones, Ling-Yan Huang, Mary W. Walker, Theresa Branchek
Publikováno v:
Peptides. 19:1771-1781
We present the molecular cloning and characterization of the human galanin receptor, hGALR2. hGALR2 shares 85%, 39%, and 57% amino acid identities to rGALR2, hGALR1, and hGALR3, respectively. hGALR2, along with rGALR2, can be distinguished from the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247edf96a3c90cbf25ef537d1d4f1282
https://doi.org/10.1016/s0196-9781(98)00133-8
https://doi.org/10.1016/s0196-9781(98)00133-8