Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Christophe Meille"'
Autor:
Mélanie Wilbaux, David Demanse, Yi Gu, Astrid Jullion, Andrea Myers, Vasiliki Katsanou, Christophe Meille
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 8, Pp 1122-1134 (2022)
Abstract Machine learning (ML) opens new perspectives in identifying predictive factors of efficacy among a large number of patients’ characteristics in oncology studies. The objective of this work was to combine ML with population pharmacokinetic/
Externí odkaz:
https://doaj.org/article/210944c07ba5437595e64f107a7269f0
Autor:
Oliver Sander, Baldur Magnusson, Inga Ludwig, Astrid Jullion, Christophe Meille, Daniel Lorand, Björn Bornkamp, Markus Hinder, Steven J. Kovacs, Michael Looby
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1276-1280 (2021)
Abstract Optimizing new drug therapies remains a challenge for clinical development, despite the use of ever more sophisticated quantitative methodologies. Although conceptually simple, the idea of finding the right treatment at the right dose for th
Externí odkaz:
https://doaj.org/article/15d1549b9b844cf58ce62297612b8cf4
Autor:
Mélanie Wilbaux, Shu Yang, Astrid Jullion, David Demanse, Diana Graus Porta, Andrea Myers, Christophe Meille, Yi Gu
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:1329-1339
Model-informed dose selection has been drawing increasing interest in oncology early clinical development. The current paper describes the example of FGF401, a selective fibroblast growth factor receptor 4 (FGFR4) inhibitor, in which a comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa51648b7bb57396c59e89a3f541768b
https://doi.org/10.1002/cpt.2752
https://doi.org/10.1002/cpt.2752
Autor:
Kathryn Packman, Lyubomir Vassilev, David Heimbrook, Christophe Meille, Michael Linn, Rosario Garrido, Violeta Adames, Shahid Tannu, Kenneth Kolinsky, Edmund Lee, Sazzad Hussain, Zoran Filipovic, Christian Tovar, Antje Walz, Kelli Glenn, Brian Higgins
PDF file - 311KB, Table S1. Results of proliferation assay. Table S2. Estimated PKPD population parameters. Fig. S1. Schematic view of the PK/PD model. Fig S2. Observed PK parameter and model predicted. Fig S3. Visual predictive check.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03937509c03c999ff11b402c64c3a3e1
https://doi.org/10.1158/1078-0432.22456187
https://doi.org/10.1158/1078-0432.22456187
Autor:
Nicolas André, Eddy Pasquier, Laetitia Padovani, Sarah Giacometti, Cindy Serdjebi, Aurélie Lombard, Christophe Meille, Dominique Barbolosi, Joseph Ciccolini
Bioluminescence of GI-ME-N-Luc+ cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2900fb0660e7c94f72b3e13eba418b
https://doi.org/10.1158/0008-5472.22414493.v1
https://doi.org/10.1158/0008-5472.22414493.v1
Autor:
Nicolas André, Eddy Pasquier, Laetitia Padovani, Sarah Giacometti, Cindy Serdjebi, Aurélie Lombard, Christophe Meille, Dominique Barbolosi, Joseph Ciccolini
Legends of Figures S1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b327cab47799d3ac8b523571fbe18f
https://doi.org/10.1158/0008-5472.22414484.v1
https://doi.org/10.1158/0008-5472.22414484.v1
Autor:
Dominique Barbolosi, Xavier Muracciole, Fabrice Barlesi, Joseph Ciccolini, Nicolas André, Christophe Meille, Laetitia Padovani, Sebastien Benzekry, Raphael Serre
Combining radiotherapy with immune checkpoint blockade may offer considerable therapeutic impact if the immunosuppressive nature of the tumor microenvironment (TME) can be relieved. In this study, we used mathematical models, which can illustrate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d341a2d6652a186d75a812304a5d7b
https://doi.org/10.1158/0008-5472.c.6508790.v1
https://doi.org/10.1158/0008-5472.c.6508790.v1
Autor:
Cecilia Carpio, Claire Fabre, Ensar Halilovic, Luisa Mariconti, Bernard Pereira, Rajkumar Radhakrishnan, Christophe Meille, Nelson Guerreiro, Stephane Ferretti, Hironobu Minami, Jordi Esteve, Rogier Mous, Noboru Yamamoto, Jean-Jacques Kiladjian, David Tai, Philippe A. Cassier, Neeltje Steeghs, Filip de Vos, Cristina Suarez, Chia-Chi Lin, Sebastian Bauer, Manik Chatterjee, Jörg Chromik, Daniel J. DeAngelo, Eytan M. Stein
Purpose:This phase I, dose-escalation study investigated the recommended dose for expansion (RDE) of siremadlin, a p53–MDM2 inhibitor, in patients with wild-type TP53 advanced solid or hematologic cancers.Patients and Methods:Initial dosing regimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28942b81cf7faf97e16f27edea45250f
https://doi.org/10.1158/1078-0432.c.6530909.v1
https://doi.org/10.1158/1078-0432.c.6530909.v1
Autor:
Kathryn Packman, Lyubomir Vassilev, David Heimbrook, Christophe Meille, Michael Linn, Rosario Garrido, Violeta Adames, Shahid Tannu, Kenneth Kolinsky, Edmund Lee, Sazzad Hussain, Zoran Filipovic, Christian Tovar, Antje Walz, Kelli Glenn, Brian Higgins
Purpose: Antitumor clinical activity has been demonstrated for the MDM2 antagonist RG7112, but patient tolerability for the necessary daily dosing was poor. Here, utilizing RG7388, a second-generation nutlin with superior selectivity and potency, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b1e546610afd48a3c935087a456191
https://doi.org/10.1158/1078-0432.c.6523232.v1
https://doi.org/10.1158/1078-0432.c.6523232.v1
Autor:
Nicolas André, Eddy Pasquier, Laetitia Padovani, Sarah Giacometti, Cindy Serdjebi, Aurélie Lombard, Christophe Meille, Dominique Barbolosi, Joseph Ciccolini
Metronomic chemotherapy is usually associated with better tolerance than conventional chemotherapy, and encouraging response rates have been reported in various settings. However, clinical development of metronomic chemotherapy has been hampered by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb1ab43868d4c6e01a6da1801c936e2
https://doi.org/10.1158/0008-5472.c.6508997.v1
https://doi.org/10.1158/0008-5472.c.6508997.v1