The colibactin-producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance

Autor: Nilmara de Oliveira Alves, Guillaume Dalmasso, Darja Nikitina, Amaury Vaysse, Richard Ruez, Lea Ledoux, Thierry Pedron, Emma Bergsten, Olivier Boulard, Lora Autier, Sofian Allam, Laurence Motreff, Pierre Sauvanet, Diane Letourneur, Pragya Kashyap, Johan Gagnière, Denis Pezet, Catherine Godfraind, Michel Salzet, Emmanuel Lemichez, Mathilde Bonnet, Imène Najjar, Christophe Malabat, Marc Monot, Denis Mestivier, Nicolas Barnich, Pankaj Yadav, Isabelle Fournier, Sean Kennedy, Amel Mettouchi, Richard Bonnet, Iradj Sobhani, Mathias Chamaillard

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

ABSTRACTIntratumoral bacteria flexibly contribute to cellular and molecular tumor heterogeneity for supporting cancer recurrence through poorly understood mechanisms. Using spatial metabolomic profiling technologies and 16SrRNA sequencing, we herein

Externí odkaz: https://doaj.org/article/8c88e5e7aa7c4e8590455a2c80f8cc28

Long Open Reading Frame Transcripts Escape Nonsense-Mediated mRNA Decay in Yeast

Autor: Laurence Decourty, Antonia Doyen, Christophe Malabat, Emmanuel Frachon, Delphine Rispal, Bertrand Séraphin, Frank Feuerbach, Alain Jacquier, Cosmin Saveanu

Publikováno v: Cell Reports, Vol 6, Iss 4, Pp 593-598 (2014)

Nonsense-mediated mRNA decay (NMD) destabilizes eukaryotic transcripts with long 3′ UTRs. To investigate whether other transcript features affect NMD, we generated yeast strains expressing chromosomal-derived mRNAs with 979 different promoter and o

Externí odkaz: https://doaj.org/article/7e77ba57b9334124ad7b0f22e19c7d82

Sodium selenide toxicity is mediated by O2-dependent DNA breaks.

Autor: Gérald Peyroche, Cosmin Saveanu, Marc Dauplais, Myriam Lazard, François Beuneu, Laurence Decourty, Christophe Malabat, Alain Jacquier, Sylvain Blanquet, Pierre Plateau

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36343 (2012)

Hydrogen selenide is a recurrent metabolite of selenium compounds. However, few experiments studied the direct link between this toxic agent and cell death. To address this question, we first screened a systematic collection of Saccharomyces cerevisi

Externí odkaz: https://doaj.org/article/e9c6b80a22464d87a2bdee148b2d7bd3

SHAMAN: a user-friendly website for metataxonomic analysis from raw reads to statistical analysis

Autor: Pierre Lechat, Laurence Motreff, Amine Ghozlane, Stevenn Volant, Christophe Malabat, Perrine Woringer, Pascal Campagne, Sean Kennedy

Publikováno v: BMC Bioinformatics, Vol 21, Iss 1, Pp 1-15 (2020)
BMC Bioinformatics
BMC Bioinformatics, 2020, 21 (1), pp.345. ⟨10.1186/s12859-020-03666-4⟩
BMC Bioinformatics, BioMed Central, 2020, 21 (1), pp.345. ⟨10.1186/s12859-020-03666-4⟩

Background Comparing the composition of microbial communities among groups of interest (e.g., patients vs healthy individuals) is a central aspect in microbiome research. It typically involves sequencing, data processing, statistical analysis and gra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4490f3bad7ceb345f5e42f820eb087e6
http://link.springer.com/article/10.1186/s12859-020-03666-4

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

Autor: Cosmin Saveanu, Laurence Decourty, Emmanuel Frachon, Christophe Malabat, Alain Jacquier

Gene deletion and gene expression alteration can lead to growth defects that are amplified or reduced when a second mutation is present in the same cells. We performed 154 genetic interaction mapping (GIM) screens with mutants related with RNA metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f083dbc23c88422be3a655c3ce4c17db
https://doi.org/10.1101/2020.10.04.325191