Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christophe M. Filippi"'
Autor:
Christophe M Filippi
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Externí odkaz:
https://doaj.org/article/ad4114487ce6456d9613baeb6652be12
Autor:
Richard Glynne, Bryan Laffitte, Peter McNamara, George Harb, Weidong Wang, V. Deshmukh, Matthew S. Tremblay, Charles Y. Cho, You Qing Zhang, Ann E. Herman, Peter G. Schultz, Jonathan G. Swoboda, Janine E. Baaten, Weijun Shen, Tom Y.-H. Wu, Christophe M. Filippi, Jing Li, Qihui Jin, Anwesh Kamireddy, Xu Wu
Publikováno v:
Journal of the American Chemical Society. 135:1669-1672
The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based screens using rodent β cell lines t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bd49122d522040efaa9a74797d00bd
https://doi.org/10.1021/ja309304m
https://doi.org/10.1021/ja309304m
Autor:
Janine Oldham, Par Larsson, Katrin Ehrhardt, Matthias von Herrath, Christophe M. Filippi, Elizabeth A. Estes
Publikováno v:
European Journal of Immunology. 41:1399-1409
Signaling through Toll-like receptor 2 (TLR2) promotes inflammation and modulates CD4+CD25+ regulatory T cells (Tregs). We assessed mechanistically how this molecule would alter immunoregulation in type 1 diabetes (T1D). We also asked whether TLR2 ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95cb30e9d6cd274c164598bb4268f3b9
https://doi.org/10.1002/eji.200939841
https://doi.org/10.1002/eji.200939841
Autor:
Janine Oldham, Diane Rottembourg, Damien Bresson, Katrin Ehrhardt, Christophe M. Filippi, Elizabeth A. Estes, Matthias von Herrath
Publikováno v:
The Journal of Immunology. 184:7100-7107
One of the requirements for efficient vaccination against infection is to achieve the best combination of an adequate adjuvant with the antigenic information to deliver. Although plasmid DNA is a promising tool bearing the unique potential to activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23017f2dff0f091f348d4a7be41830c
https://doi.org/10.4049/jimmunol.0803935
https://doi.org/10.4049/jimmunol.0803935
Publikováno v:
Future Virology. 4:407-410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::755a5774774411a7463a9cea84911607
https://doi.org/10.2217/fvl.09.28
https://doi.org/10.2217/fvl.09.28
Publikováno v:
Diabetes. 57:2863-2871
The most popular hypothesis circulating within and beyond the scientific community is that viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can injure β-cells and have been isolated in pancreatic tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b0397911549276779ade9b166b25e82
https://doi.org/10.2337/db07-1023
https://doi.org/10.2337/db07-1023
Publikováno v:
The Journal of Pathology. 214:224-230
Chronic viral infections pose serious health concerns, as secondary complications such as immunodeficiencies and cancers are common. Treating such infections with conventional vaccine approaches has proved to be difficult. Studies in animals and huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00fb6b43fcbdae694579cecd0ea4b4e
https://doi.org/10.1002/path.2272
https://doi.org/10.1002/path.2272
Publikováno v:
Expert Review of Endocrinology & Metabolism. 2:185-194
Type 1 diabetes results from autoimmune destruction of insulin-producing β cells in the pancreatic islets, leading to deficiency in glucose uptake by the cells of the body. The resulting complications and mortality call into attention the need for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd26c9931236236fe935d6fa0a26c3a
https://doi.org/10.1586/17446651.2.2.185
https://doi.org/10.1586/17446651.2.2.185
Autor:
Nicolas Glaichenhaus, Valérie Julia, Julie Cazareth, Stéphanie Hugues, Sophie Ugolini, Christophe M. Filippi
Publikováno v:
The Journal of Experimental Medicine
Resistance and susceptibility to Leishmania major in mice are determined by multiple genes and correlate with the preferential development of Th1 and Th2 responses, respectively. Here, we found that CD11b+ dendritic cells (DCs) prime parasite-specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec13127e79abd1db8bd40713d50e7b8
http://europepmc.org/articles/PMC2194066
http://europepmc.org/articles/PMC2194066
Autor:
Luis Brito, Ennio De Gregorio, Susanna Aprea, Samuele Calabrό, Chun Li, Francesco Doro, Sina Bavari, Miller Andrew T, David A. G. Skibinski, Rekha G. Panchal, Donatello Laera, M. Lamine Mbow, Simone Bufali, Ann E. Herman, Ugo D'Oro, Michael P. Cooke, Elaine Tritto, Padma Malyala, Brunella Brunelli, Elisabetta Monaci, Alex Cortez, Gillis R. Otten, Sara Valentini, Travis K. Warren, Christophe M. Filippi, Nicholas Valiante, Yongkai Li, Tom Y.-H. Wu, Bishnu P. Nayak, Manmohan Singh, Elena Caproni, Derek T. O'Hagan
Publikováno v:
Science translational medicine. 6(263)
Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major hurdle for adjuvant use in vaccines for humans. It has been difficult to improve on adjuvan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0d1bdbb2ebc009cbc67a1ff4484d95
https://pubmed.ncbi.nlm.nih.gov/25411473
https://pubmed.ncbi.nlm.nih.gov/25411473