Inferring upstream regulatory genes of FOXP3 in human regulatory T cells from time-series transcriptomic data

Autor: Stefano Magni, Rucha Sawlekar, Christophe M. Capelle, Vera Tslaf, Alexandre Baron, Ni Zeng, Laurent Mombaerts, Zuogong Yue, Ye Yuan, Feng Q. Hefeng, Jorge Gonçalves

Publikováno v: npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)

Abstract The discovery of upstream regulatory genes of a gene of interest still remains challenging. Here we applied a scalable computational method to unbiasedly predict candidate regulatory genes of critical transcription factors by searching the w

Externí odkaz: https://doaj.org/article/ed7e7d476a09458eb90fc0009e2c3a12

Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells

Autor: Christophe M. Capelle, Ni Zeng, Egle Danileviciute, Sabrina Freitas Rodrigues, Markus Ollert, Rudi Balling, Feng Q. He

Publikováno v: iScience, Vol 24, Iss 4, Pp 102289- (2021)

Summary: Many players regulating the CD4+ T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a

Externí odkaz: https://doaj.org/article/4add58a0cf834c9c8900a476cf93ea34

Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1

Autor: Christophe M. Capelle, Anna Chen, Ni Zeng, Alexandre Baron, Kamil Grzyb, Thais Arns, Alexander Skupin, Markus Ollert, Feng Q. Hefeng

Publikováno v: Capelle, C M, Chen, A, Zeng, N, Baron, A, Grzyb, K, Arns, T, Skupin, A, Ollert, M & Hefeng, F Q 2022, ' Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1 ', Immunology, vol. 165, no. 4, pp. 428-444 . https://doi.org/10.1111/imm.13448

Stress hormones are believed to skew the CD4 T-cell differentiation towards a Th2 response via a T-cell-extrinsic mechanism. Using isolated primary human naïve and memory CD4 T cells, here we show that both adrenergic- and glucocorticoid-mediated st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb3fed57211c1b36adfa6ca2cf599d7
https://www.ncbi.nlm.nih.gov/pubmed/35143696

Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

Autor: Christophe M. Capelle, Séverine Ciré, Olivia Domingues, Isabelle Ernens, Fanny Hedin, Aurélie Fischer, Chantal J. Snoeck, Wim Ammerlaan, Maria Konstantinou, Kamil Grzyb, Alexander Skupin, Cara L. Carty, Christiane Hilger, Georges Gilson, Aljosa Celebic, Paul Wilmes, Antonio Del Sol, Ian M. Kaplan, Fay Betsou, Tamir Abdelrahman, Antonio Cosma, Michel Vaillant, Guy Fagherazzi, Markus Ollert, Feng Q. Hefeng

Publikováno v: Capelle, C M, Ciré, S, Domingues, O, Ernens, I, Hedin, F, Fischer, A, Snoeck, C J, Ammerlaan, W, Konstantinou, M, Grzyb, K, Skupin, A, Carty, C L, Hilger, C, Gilson, G, Celebic, A, Wilmes, P, Del Sol, A, Kaplan, I M, Betsou, F, Abdelrahman, T, Cosma, A, Vaillant, M, Fagherazzi, G, Ollert, M & Hefeng, F Q 2022, ' Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients ', Cell Reports Medicine, vol. 3, no. 4, 100600 . https://doi.org/10.1016/j.xcrm.2022.100600

While immunopathology has been widely studied in patients with severe COVID-19, immune responses in non-hospitalized patients have remained largely elusive. We systematically analyze 484 peripheral cellular or soluble immune features in a longitudina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18e7bf892ea4f97477ba8eb53ae07af
https://doi.org/10.1016/j.xcrm.2022.100600