Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Christophe Lemaire"'
Autor:
Marianne Mazevet, Anissa Belhadef, Maxance Ribeiro, Delphine Dayde, Anna Llach, Marion Laudette, Tiphaine Belleville, Philippe Mateo, Mélanie Gressette, Florence Lefebvre, Ju Chen, Christilla Bachelot-Loza, Catherine Rucker-Martin, Frank Lezoualch, Bertrand Crozatier, Jean-Pierre Benitah, Marie-Catherine Vozenin, Rodolphe Fischmeister, Ana-Maria Gomez, Christophe Lemaire, Eric Morel
Publikováno v:
eLife, Vol 12 (2023)
Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy and heart failure. Thi
Externí odkaz:
https://doaj.org/article/cdffeb33bb6c47cd87e41bc7a93230d4
Autor:
Lucile Grimbert, Maria-Nieves Sanz, Mélanie Gressette, Catherine Rucker-Martin, Marta Novotova, Audrey Solgadi, Ahmed Karoui, Susana Gomez, Kaveen Bedouet, Eric Jacquet, Christophe Lemaire, Vladimir Veksler, Mathias Mericskay, Renée Ventura-Clapier, Jérôme Piquereau, Anne Garnier
Publikováno v:
Biology of Sex Differences, Vol 12, Iss 1, Pp 1-24 (2021)
Highlights AMPK is a metabolic sensor of cellular energy which regulates energy homeostasis. We generated a cardiac-specific inducible deletion of Ampkα2 and demonstrated that this deletion induces mild cardiac dysfunction in male only. Cardiac dysf
Externí odkaz:
https://doaj.org/article/81438108d8ef4b59a82a8ad86e49fea4
Autor:
Bruno Le Cam, Dan Sargent, Jérôme Gouzy, Joëlle Amselem, Marie-Noëlle Bellanger, Olivier Bouchez, Spencer Brown, Valérie Caffier, Marie De Gracia, Robert Debuchy, Ludovic Duvaux, Thibaut Payen, Mélanie Sannier, Jason Shiller, Jérôme Collemare, Christophe Lemaire
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 8, Pp 2405-2414 (2019)
The Venturia genus comprises fungal species that are pathogens on Rosaceae host plants, including V. inaequalis and V. asperata on apple, V. aucupariae on sorbus and V. pirina on pear. Although the genetic structure of V. inaequalis populations has b
Externí odkaz:
https://doaj.org/article/9fd96eb71c04424daef8f0eb0c2fcd1d
Autor:
Kévin Monceaux, Mélanie Gressette, Ahmed Karoui, Julie Pires Da Silva, Jérôme Piquereau, Renée Ventura-Clapier, Anne Garnier, Mathias Mericskay, Christophe Lemaire
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6628 (2022)
Disturbances in Endoplasmic Reticulum (ER) homeostasis induce ER stress, which has been involved in the development and progression of various heart diseases, including arrhythmias, cardiac hypertrophy, ischemic heart diseases, dilated cardiomyopathy
Externí odkaz:
https://doaj.org/article/200a60355617416fb55f3cf330a6bf92
Autor:
Laure Delavallée, Navrita Mathiah, Lauriane Cabon, Aurélien Mazeraud, Marie-Noelle Brunelle-Navas, Leticia K. Lerner, Mariana Tannoury, Alexandre Prola, Raquel Moreno-Loshuertos, Mathieu Baritaud, Laura Vela, Kevin Garbin, Delphine Garnier, Christophe Lemaire, Francina Langa-Vives, Martine Cohen-Salmon, Patricio Fernández-Silva, Fabrice Chrétien, Isabelle Migeotte, Santos A. Susin
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101027- (2020)
Objectives: Apoptosis-Inducing Factor (AIF) is a protein involved in mitochondrial electron transport chain assembly/stability and programmed cell death. The relevant role of this protein is underlined because mutations altering mitochondrial AIF pro
Externí odkaz:
https://doaj.org/article/8c134e4208ad45a592079ac9a2feb0b1
Autor:
Julie Pires Da Silva, Kevin Monceaux, Arnaud Guilbert, Mélanie Gressette, Jérôme Piquereau, Marta Novotova, Renée Ventura-Clapier, Anne Garnier, Christophe Lemaire
Publikováno v:
Cells, Vol 9, Iss 2, p 426 (2020)
Many recent studies have demonstrated the involvement of endoplasmic reticulum (ER) stress in the development of cardiac diseases and have suggested that modulation of ER stress response could be cardioprotective. Previously, we demonstrated that the
Externí odkaz:
https://doaj.org/article/2eb415e5574d4cb98b34c4e39bb2a8f0
Autor:
Hélène Le Guillou-Guillemette, Adeline Pivert, Elise Bouthry, Cécile Henquell, Odile Petsaris, Alexandra Ducancelle, Pascal Veillon, Sophie Vallet, Sophie Alain, Vincent Thibault, Florence Abravanel, Arielle A Rosenberg, Elisabeth André-Garnier, Jean-Baptiste Bour, Yazid Baazia, Pascale Trimoulet, Patrice André, Catherine Gaudy-Graffin, Dominique Bettinger, Sylvie Larrat, Anne Signori-Schmuck, Hénia Saoudin, Bruno Pozzetto, Gisèle Lagathu, Sophie Minjolle-Cha, Françoise Stoll-Keller, Jean-Michel Pawlotsky, Jacques Izopet, Christopher Payan, Françoise Lunel-Fabiani, Christophe Lemaire
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174651 (2017)
BACKGROUND:The emergence of new strains in RNA viruses is mainly due to mutations or intra and inter-genotype homologous recombination. Non-homologous recombinations may be deleterious and are rarely detected. In previous studies, we identified HCV-1
Externí odkaz:
https://doaj.org/article/3345e59bdd8a4843af957f74db745733
Autor:
Maria-Nieves Sanz, Lucile Grimbert, Maryline Moulin, Mélanie Gressette, Catherine Rucker-Martin, Christophe Lemaire, Mathias Mericskay, Vladimir Veksler, Renée Ventura-Clapier, Anne Garnier, Jérôme Piquereau
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5005 (2019)
Heart failure is associated with profound alterations of energy metabolism thought to play a major role in the progression of this syndrome. SIRT1 is a metabolic sensor of cellular energy and exerts essential functions on energy metabolism, oxidative
Externí odkaz:
https://doaj.org/article/ebb368a4e1864792ae8eaf055cc74bf6
Autor:
Marie De Gracia, Mathilde Cascales, Pascale Expert, Marie-Noelle Bellanger, Bruno Le Cam, Christophe Lemaire
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0122909 (2015)
Understanding evolutionary dynamics of pathogens during domestication of their hosts and rise of agro-ecosystems is essential for durable disease management. Here, we investigated changes in life-history traits of the fungal pathogen Venturia inaequa
Externí odkaz:
https://doaj.org/article/4338c98ddaf44442af99d101ce66cd87
Autor:
Nadia Mhedbi-Hajri, Ahmed Hajri, Tristan Boureau, Armelle Darrasse, Karine Durand, Chrystelle Brin, Marion Fischer-Le Saux, Charles Manceau, Stéphane Poussier, Olivier Pruvost, Christophe Lemaire, Marie-Agnès Jacques
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58474 (2013)
Deciphering mechanisms shaping bacterial diversity should help to build tools to predict the emergence of infectious diseases. Xanthomonads are plant pathogenic bacteria found worldwide. Xanthomonas axonopodis is a genetically heterogeneous species c
Externí odkaz:
https://doaj.org/article/747271c53a1c45ec8b8c722562f38b0c